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Home > Products > Pharmaceuticals & Life Science > Pharmaceutical Intermediates > N-Boc-cis-4-hydroxy-D-proline
N-Boc-cis-4-hydroxy-D-proline structure, CAS 135042-12-5

N-Boc-cis-4-hydroxy-D-proline

CAS Number135042-12-5

Synonyms(2R,4R)-1-(tert-Butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid; N-Boc-cis-4-Hydroxy-D-proline; (4S)-4-Hydroxy-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-proline; (4R)-4-Hydroxy-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-D-proline; (2R,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid; (2R,4R)-N-Boc-4-hydroxy-2-pyrrolidinecarboxylic acid; MFCD02094407

Molecular FormulaC10H17NO5

Molecular Weight231.25

Purity97%

Density1.3±0.1 g/cm3

Boiling Point390.9±42.0 °C at 760 mmHg

Melting Point119-125 °C

Flash Point

Appearancesolid

EINECS

MSDSChineseEnglish

Symboltransportation

Signal WordWarning

Cat. No.: 2A-9075820 Purity: 97%
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Quality Control of [ 135042-12-5 ] Purity: 97% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number135042-12-5
Catalog No.2A-9075820
Chinese NameN-Boc-顺式-4-羟基-D-脯氨酸
Synonyms(2R,4R)-1-(tert-Butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid; N-Boc-cis-4-Hydroxy-D-proline; (4S)-4-Hydroxy-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-proline; (4R)-4-Hydroxy-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-D-proline; (2R,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid; (2R,4R)-N-Boc-4-hydroxy-2-pyrrolidinecarboxylic acid; MFCD02094407
Molecular FormulaC10H17NO5
Molecular Weight231.25
Purity97
Density1.3±0.1 g/cm3
Boiling Point390.9±42.0 °C at 760 mmHg
Melting Point119-125 °C
Appearancesolid
Storage ConditionKeep the container sealed and stored in a cool, dr
ApplicationN-Boc-cis-4-hydroxy-D-proline is a non-cleavable ADC linker used in the synthesis of antibody drug conjugates (ADC). N-Boc-cis-4-hydroxy-D-proline is also an alkyl chain-based PROTAC linker that can b
HTC2933990090
PubChem ID329766602
MDL NumberMFCD23135644
SMILESCC(C)(C)OC(=O)N1C[C@@H](O)CC1C(O)=O
InChI1S/C10H17NO5/c1-10(2,3)16-9(15)11-5-6(12)4-7(11)8(13)14/h6-7,12H,4-5H2,1-3H3,(H,13,14)/t6-,7?/m0/s1
InChI KeyBENKAPCDIOILGV-PKPIPKONSA-N
NACRES CodeNA.22
UNSPSC12352209
Hazard Symbolstransportation
MSDSmsds/75820_1_135042_12_5.pdf
BioactivityN-Boc-cis-4-Hydroxy-D-proline is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-Hydroxy-D-proline is also a alkyl chain-based PROTAC linker that can be used in the synth Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker Target Non-cleavable In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. References [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 390.9±42.0 °C at 760 mmHg Melting Point 145ºC Molecular Formula C10H17NO5 Molecular Weight 231.246 Flash Point 190.2±27.9 °C Exact Mass 231.110672 PSA 87.07000 LogP -0.71 Vapour Pressure 0.0±2.0 mmHg at 25°C Index of Refraction 1.531 InChIKey BENKAPCDIOILGV-RNFRBKRXSA-N SMILES CC(C)(C)OC(=O)N1CC(O)CC1C(=O)O Storage condition 2-8°C
Use ofN-Boc-cis-4-Hydroxy-D-proline is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-Hydroxy-D-proline is also a alkyl chain-based PROTAC linker that can be used in the synth Properties Name Boc-Cis-4-Hydroxy-D-Proline Synonym More Synonyms N-Boc-cis-4-Hydroxy-D-proline Biological Activity Description N-Boc-cis-4-Hydroxy-D-proline is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-Hydroxy-D-proline is also a alkyl chain-based PROTAC linker that can be used in the synth Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker Non-cleavable In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. References [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. Chemical & Physical Properties Molecular Formula C10H17NO5 Exact Mass 231.110672 PSA 87.07000 LogP -0.71 Index of Refraction 1.531 InChIKey BENKAPCDIOILGV-RNFRBKRXSA-N
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Purity: 99.0%
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available
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