![3-(6-(DIMETHYLAMINO)-4-METHYLPYRIDIN-3-YL)-2,5-DIMETHYL-N,N-DIPROPYLPYRAZOLO[1,5-A]PYRIMIDIN-7-AMINE structure, CAS 195055-03-9](/structures/80000/74096_1_195055_03_9.png)
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 195055-03-9 |
| Catalog No. | 2A-9074096 |
| Chinese Name | R121919 |
| Synonyms | R121919 |
| Molecular Formula | C22H32N6 |
| Molecular Weight | 380.53 |
| Purity | ≥98 (HPLC) |
| Density | 1.114g/cm3 |
| Appearance | powder |
| Storage Condition | 2-8℃ |
| Application | R121919 is a highly effective small molecule CRF1 receptor antagonist. With Ki values of 2 to 5 nM for the CRF1 receptor, it is more than 1000-fold less active against the CRF2 receptor, CRF-binding |
| HTC | 2933990090 |
| PubChem ID | 14780138 |
| MDL Number | MFCD05260874 |
| SMILES | CCCN(CCC)C1=CC(C)=NC2=C(C(C)=NN12)C3=CN=C(C=C3C)N(C)C |
| InChI | 1S/C22H32N6/c1-8-10-27(11-9-2)20-13-16(4)24-22-21(17(5)25-28(20)22)18-14-23-19(26(6)7)12-15(18)3/h12-14H,8-11H2,1-7H3 |
| InChI Key | ANNRUWYFVIGKHA-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/74096_1_195055_03_9.pdf |
| Use of | R121919 is a potent small-molecule CRF1 receptor antagonist with a Ki of 2 to 5 nM for the CRF1 receptor and over 1000-fold weaker activity at the CRF2 receptor, CRF-binding protein, or 70 other receptor types. Properties Biological Activity Chemical & Physical Properties Safety Info Synthetic Route Precursor & Downstream |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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| N-CYCLOPROPYL-2-MERCAPTOACETAMIDE | 886047-44-5 | 2A-9074093 |
| 1-CARBETHOXY-3-BROMO-4-PIPERIDONE | 95629-02-0 | 2A-9074094 |
| 4-CHLORO-2,6-DIFLUOROBENZOICACID | 196194-58-8 | 2A-9074095 |
| 2-FLUORO-BENZAMIDINE | 71204-93-8 | 2A-9074098 |
| 3-(6-(DIMETHYLAMINO)-4-METHYLPYRIDIN-3-YL)-2,5-DIMETHYL-N,N-DIPROPYLPYRAZOLO[1,5-A]PYRIMIDIN-7-AMINEHYDROCHLORIDE | 195055-66-4 | 2A-9074099 |
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| 3,3'-METHYLENEDIBENZONITRILE | 46833-85-6 | 2A-9074107 |
| 2'-CHLORO-6'-METHYLBIPHENYL-4-AMINE | 1044210-29-8 | 2A-9074108 |
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