CAS Number113-92-8
Synonymsteldrin; CHLORPHENAMINE MALEATES; BISACODYL; Chlorphenamine Maleate; 3-(4-chlorophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine; 2-[p-Chloro-a-(2-dimethylaminoethyl)benzyl]pyridine; CHLOROPHENAMINEMALEATE; ChlorpheniramineMaleate; alunex; Cloropiril; M.P. chlorcaps T.D.; Chlorpheniramine (maleate); Haynon; 3-(4-Chlorophenyl)-N,N-dimethyl-3-(2-pyridinyl)-1-propanamine (2Z)-2-butenedioate (1:1); CHLORPHENAMINE HYDROGEN MALEATE, WHO STANDARD; EINECS 205-054-0; (±)-Chlorpheniramine maleate; UNII:V1Q0O9OJ9Z; Allergisan; (±)-Chlorpheniramine; 3-(4-Chlorophenyl)-N,N-dimethyl-3-(2-pyridinyl)-1-propanamine; Chlortrimeton; 2-pyridinepropanamine, g-(4-chlorophenyl)-N,N-dimethyl-, (2Z)-2-butenedioate (1:1); 3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine; piriex; Chloropheniramine mal
Molecular FormulaC20H23ClN2O4
Molecular Weight390.86
Purity99%%
Density1.1±0.1 g/cm3
Boiling Point379.0±42.0 °C at 760 mmHg
Melting Point130-135 °C (lit.)
AppearanceOdorless white crystalline solid or white powder with a bitter taste
EINECS204-037-5
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 113-92-8 |
| Catalog No. | 2A-9007400 |
| Chinese Name | 扑尔敏 |
| Synonyms | teldrin; CHLORPHENAMINE MALEATES; BISACODYL; Chlorphenamine Maleate; 3-(4-chlorophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine; 2-[p-Chloro-a-(2-dimethylaminoethyl)benzyl]pyridine; CHLOROPHENAMINEMALEATE; ChlorpheniramineMaleate; alunex; Cloropiril; M.P. chlorcaps T.D.; Chlorpheniramine (maleate); Haynon; 3-(4-Chlorophenyl)-N,N-dimethyl-3-(2-pyridinyl)-1-propanamine (2Z)-2-butenedioate (1:1); CHLORPHENAMINE HYDROGEN MALEATE, WHO STANDARD; EINECS 205-054-0; (±)-Chlorpheniramine maleate; UNII:V1Q0O9OJ9Z; Allergisan; (±)-Chlorpheniramine; 3-(4-Chlorophenyl)-N,N-dimethyl-3-(2-pyridinyl)-1-propanamine; Chlortrimeton; 2-pyridinepropanamine, g-(4-chlorophenyl)-N,N-dimethyl-, (2Z)-2-butenedioate (1:1); 3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine; piriex; Chloropheniramine mal |
| Molecular Formula | C20H23ClN2O4 |
| Molecular Weight | 390.86 |
| Purity | 99% |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 379.0±42.0 °C at 760 mmHg |
| Melting Point | 130-135 °C (lit.) |
| Appearance | Odorless white crystalline solid or white powder with a bitter taste |
| Water Solubility | 1-5 G/100 ML AT 21 ºC |
| Storage Condition | Store in a cool, ventilated warehouse. Keep away f |
| Packaging | III |
| Application | Chlorpheniramine maleate is a histamine H1 receptor antagonist with an IC50 of 12 nM. |
| EINECS | 204-037-5 |
| HTC | 2933399090 |
| UN(IATA) | UN 2811 |
| PubChem ID | 329823047 |
| MDL Number | MFCD00069225 |
| SMILES | CN(C)CCC(C1=CC=C(Cl)C=C1)C2=NC=CC=C2.O=C(/C=C\C(O)=O)O |
| InChI | 1S/C16H19ClN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1- |
| InChI Key | DBAKFASWICGISY-BTJKTKAUSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | 6.1(b) |
| Risk Codes | R25 |
| Safety Description | S36/37/39;S45 |
| MSDS | msds/7400_1_113_92_8.pdf |
| Bioactivity | Chlorpheniramine maleate is an histamine H1 receptor antagonist with IC50 of 12 nM.Target: Histamine H1 ReceptorChlorpheniramine inhibits the proliferation of MCF-7, MDA-MB 231, and Ehrlich cells in a dose-response manner, and significantly reduces the ornithine decarboxylase mRNA translation by 50%-70% at the 250 μM [1]. Chlorpheniramine displaces of [3H]pyrilamine from human histamine receptor subtype 1 expressed in CHO cells with IC50 of 66 nM. Chlorpheniramine displays antimalarial activity against CQS strain (D6) and MDR strain (Dd2) of P. falciparum with IC50 of 61.2 uM and 3.9 uM, respectively. Chlorpheniramine displays cytotoxicity against the proliferation of concanavalin A-induced murine splenic lymphocytes with IC50 of 33.4 μM [2].Oral administration of Chlorpheniramine inhibits histamine-induced mortality in guinea pigs with an ED50 of 0.17 mg/kg [3]. Oral administration of Chlorpheniramine (10 mg/kg) significantly inhibits short-duration scratching in BALB/c mice stimulated by ovalbumin active cutaneous anaphylaxis and in ICR mice subcutaneously injected with histamine, but not long-duration scratching seen in NC/Nga mice, in contrast to that of dexamethasone or tacrolimus [4]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology References [1]. Medina, M.A., et al., Chlorpheniramine inhibits the synthesis of ornithine decarboxylase and the proliferation of human breast cancer cell lines. Breast Cancer Res Treat, 1995. 35(2): p. 187-94. [2]. Kelly, J.X., et al., Design, synthesis, and evaluation of 10-N-substituted acridones as novel chemosensitizers in Plasmodium falciparum. Antimicrob Agents Chemother, 2007. 51(11): p. 4133-40. [3]. Iemura, R., et al., Synthesis of 2-(4-substituted-1-piperazinyl)benzimidazoles as H1-antihistaminic agents. J Med Chem, 1986. 29(7): p. 1178-83. [4]. Takano, N., I. Arai, and M. Kurachi, Analysis of the spontaneous scratching behavior by NC/Nga mice: a possible approach to evaluate antipruritics for subjects with atopic dermatitis. Eur J Pharmacol, 2003. 471(3): p. 223-8. Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 379.0±42.0 °C at 760 mmHg Melting Point 130-135 °C(lit.) Molecular Formula C20H23ClN2O4 Molecular Weight 390.861 Flash Point 183.0±27.9 °C Exact Mass 390.134644 PSA 90.73000 LogP 3.39 Vapour Pressure 0.0±0.9 mmHg at 25°C Index of Refraction 1.565 InChIKey DBAKFASWICGISY-UHFFFAOYSA-N SMILES CN(C)CCC(c1ccc(Cl)cc1)c1ccccn1.O=C(O)C=CC(=O)O Storage condition -20°C Freezer Water Solubility 1-5 G/100 ML AT 21 ºC |
| Use of | Properties Articles40 Name Chlorpheniramine maleate Synonym More Synonyms Chlorpheniramine maleate Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology References [1]. Medina, M.A., et al., Chlorpheniramine inhibits the synthesis of ornithine decarboxylase and the proliferation of human breast cancer cell lines. Breast Cancer Res Treat, 1995. 35(2): p. 187-94. [2]. Kelly, J.X., et al., Design, synthesis, and evaluation of 10-N-substituted acridones as novel chemosensitizers in Plasmodium falciparum. Antimicrob Agents Chemother, 2007. 51(11): p. 4133-40. [3]. Iemura, R., et al., Synthesis of 2-(4-substituted-1-piperazinyl)benzimidazoles as H1-antihistaminic agents. J Med Chem, 1986. 29(7): p. 1178-83. [4]. Takano, N., I. Arai, and M. Kurachi, Analysis of the spontaneous scratching behavior by NC/Nga mice: a possible approach to evaluate antipruritics for subjects with atopic dermatitis. Eur J Pharmacol, 2003. 471(3): p. 223-8. Chemical & Physical Properties Exact Mass 390.134644 PSA 90.73000 Index of Refraction 1.565 InChIKey DBAKFASWICGISY-UHFFFAOYSA-N Water Solubility 1-5 G/100 ML AT 21 ºC |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 99.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (Chlorphenamine hydrogen maleate) IMDG: TOXIC SOLID, ORGANIC, N.O.S. (Chlorphenamine hydrogen maleate) International air transport hazard regulations: Toxic solid, organic, n.o.s. (Chlorphenamine hydrogen maleate) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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