CAS Number1148-11-4
Synonyms(S)-N-(benzyloxycarbonyl)-proline; Cbz-L-proline; EINECS 214-557-4; (S)-1-(benzyloxycarbonyl)-pyrrolidine-2-carboxylic acid; (S)-N-CBZ-pyrrolidine-2-carboxylic acid; N-Benzyloxycarbonyl-L-proline; N-Carbobenzyloxy-L-proline; (2S)-1-[(Phenylmethoxy)carbonyl]pyrrolidine-2-carboxylic acid; Carbobenzyloxy-L-proline; MFCD00003170; N-Carbobenzoxy-L-proline; (S)-1-carbobenzoxypyrrolidine-2-carboxylic acid; MFCD00020830; Carbobenzoxy-L-proline; 1-[(Benzyloxy)carbonyl]-L-proline; N-Cbz-L-proline; N-benzyloxycarbonyl-(S)-proline; (2S)-1-Phenylmethoxycarbonylpyrrolidine-2-carboxylicacid; Z-L-Proline; Z-Pro-OH; N-[(phenyl-methoxy)carbonyl]-L-proline; Benzyloxycarbonyl-L-proline
Molecular FormulaC13H15NO4
Molecular Weight249.26
Purity99%
Density1.3±0.1 g/cm3
Boiling Point432.3±45.0 °C at 760 mmHg
Melting Point76-78 °C (lit.)
Appearancepowder or crystals
EINECS214-557-4
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1148-11-4 |
| Catalog No. | 2A-9007385 |
| Chinese Name | N-CBZ-L-脯氨酸 |
| Synonyms | (S)-N-(benzyloxycarbonyl)-proline; Cbz-L-proline; EINECS 214-557-4; (S)-1-(benzyloxycarbonyl)-pyrrolidine-2-carboxylic acid; (S)-N-CBZ-pyrrolidine-2-carboxylic acid; N-Benzyloxycarbonyl-L-proline; N-Carbobenzyloxy-L-proline; (2S)-1-[(Phenylmethoxy)carbonyl]pyrrolidine-2-carboxylic acid; Carbobenzyloxy-L-proline; MFCD00003170; N-Carbobenzoxy-L-proline; (S)-1-carbobenzoxypyrrolidine-2-carboxylic acid; MFCD00020830; Carbobenzoxy-L-proline; 1-[(Benzyloxy)carbonyl]-L-proline; N-Cbz-L-proline; N-benzyloxycarbonyl-(S)-proline; (2S)-1-Phenylmethoxycarbonylpyrrolidine-2-carboxylicacid; Z-L-Proline; Z-Pro-OH; N-[(phenyl-methoxy)carbonyl]-L-proline; Benzyloxycarbonyl-L-proline |
| Molecular Formula | C13H15NO4 |
| Molecular Weight | 249.26 |
| Purity | 99 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 432.3±45.0 °C at 760 mmHg |
| Melting Point | 76-78 °C (lit.) |
| Appearance | powder or crystals |
| Storage Condition | Sealed, stored at 2ºC -8ºC |
| Application | Carbophenoxyproline (L-Cbz-proline) is an inhibitor of prolinase. Carbophenoxyproline can be used in prolinase deficiency (PD) research [1]. |
| EINECS | 214-557-4 |
| HTC | 2933990090 |
| PubChem ID | 24893080 |
| MDL Number | MFCD00003170 |
| SMILES | OC(=O)[C@@H]1CCCN1C(=O)OCc2ccccc2 |
| InChI | 1S/C13H15NO4/c15-12(16)11-7-4-8-14(11)13(17)18-9-10-5-2-1-3-6-10/h1-3,5-6,11H,4,7-9H2,(H,15,16)/t11-/m0/s1 |
| InChI Key | JXGVXCZADZNAMJ-NSHDSACASA-N |
| Beilstein/REAXYS | 88579 |
| NACRES Code | NA.22 |
| eCl@ss | 32160406 |
| UNSPSC | 12352209 |
| Hazard Symbols | Transport |
| Safety Description | S24/25 |
| MSDS | msds/7385_1_1148_11_4.pdf |
| Bioactivity | Carbobenzoxyproline (L-Cbz-Proline) is an inhibitor of prolidase. Carbobenzoxyproline can be used for prolidase deficiency (PD) research[1]. Related Catalog Research Areas >> Others Signaling Pathways >> Others >> Others In Vitro Carbobenzoxyproline (6 mM; 0-10 d; pH=6.0) causes mitochondrial depolarization and increases cellular death by 33% as reported for long-term culture of fibroblasts from prolidase deficiency (PD) patients[1]. Carbobenzoxyproline (0, 1, 3, 6 mM; 1 min; pH=6.0) results fibroblasts prolidase (FBP) hydrolysis, shows linear competitive inhibition[1]. In Vivo Carbobenzoxyproline (60 mg/kg; injection; once daily; 3 weeks) serves as in vivo inhibitor of erythrocytes prolidase in mice model[1]. Animal Model: C57Bl/6J mice (4-week-old)[1] Dosage: 60 mg/kg Administration: Injection; once daily for 3 weeks Result: Resulted significant reduction of erythrocytes prolidase activity. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 432.3±45.0 °C at 760 mmHg Melting Point 76-78ºC Molecular Formula C13H15NO4 Molecular Weight 249.262 Flash Point 215.3±28.7 °C Exact Mass 249.100113 PSA 66.84000 LogP 1.17 Vapour Pressure 0.0±1.1 mmHg at 25°C Index of Refraction 1.582 InChIKey JXGVXCZADZNAMJ-NSHDSACASA-N SMILES O=C(O)C1CCCN1C(=O)OCc1ccccc1 Storage condition 2~8°C |
| Use of | Carbobenzoxyproline (L-Cbz-Proline) is an inhibitor of prolidase. Carbobenzoxyproline can be used for prolidase deficiency (PD) research[1]. Properties Name (2S)-1-phenylmethoxycarbonylpyrrolidine-2-carboxylic acid Synonym More Synonyms Z-Pro-OH Biological Activity Description Carbobenzoxyproline (L-Cbz-Proline) is an inhibitor of prolidase. Carbobenzoxyproline can be used for prolidase deficiency (PD) research[1]. Related Catalog Research Areas >> Others Signaling Pathways >> Others >> Others Chemical & Physical Properties Molecular Formula C13H15NO4 Exact Mass 249.100113 PSA 66.84000 Index of Refraction 1.582 InChIKey JXGVXCZADZNAMJ-NSHDSACASA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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