CAS Number136434-34-9
Synonyms2-thiophenepropanamine, N-methyl-γ-(1-naphthalenyloxy)-, (γS)-, hydrochloride; (S)-(+)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine Hydrochloride; (+)-(S)-N-methyl-g-(1-naphthyloxy)-2-thiophenepropylamine Hydrochloride; (3S)-N-méthyl-3-(naphtalén-1-yloxy)-3-thiophén-2-ylpropan-1-amine chlorhydrate; (S)-Duloxetine hydrochloride; (3S)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)propan-1-amine hydrochloride (1:1); (S)-N-Methyl-g-(1-naphthalenyloxy)-2-thiophenepropanamine Hydrochloride; duloxetine hcl; 2-Thiophenepropanamine, N-methyl-γ-(1-naphthalenyloxy)-, (γS)-, hydrochloride (1:1); (S)-N-Methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine hydrochloride; (3S)-N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-ylpropan-1-amine,hydrochloride; (3S)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)
Molecular FormulaC18H20ClNOS
Molecular Weight333.88
Boiling Point466.2ºC at 760 mmHg
Melting Point118-122ºC
Appearanceliquid
EINECS200-659-6
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 136434-34-9 |
| Catalog No. | 2A-9073693 |
| Chinese Name | 盐酸度洛西汀 |
| Synonyms | 2-thiophenepropanamine, N-methyl-γ-(1-naphthalenyloxy)-, (γS)-, hydrochloride; (S)-(+)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine Hydrochloride; (+)-(S)-N-methyl-g-(1-naphthyloxy)-2-thiophenepropylamine Hydrochloride; (3S)-N-méthyl-3-(naphtalén-1-yloxy)-3-thiophén-2-ylpropan-1-amine chlorhydrate; (S)-Duloxetine hydrochloride; (3S)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)propan-1-amine hydrochloride (1:1); (S)-N-Methyl-g-(1-naphthalenyloxy)-2-thiophenepropanamine Hydrochloride; duloxetine hcl; 2-Thiophenepropanamine, N-methyl-γ-(1-naphthalenyloxy)-, (γS)-, hydrochloride (1:1); (S)-N-Methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine hydrochloride; (3S)-N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-ylpropan-1-amine,hydrochloride; (3S)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl) |
| Molecular Formula | C18H20ClNOS |
| Molecular Weight | 333.88 |
| Boiling Point | 466.2ºC at 760 mmHg |
| Melting Point | 118-122ºC |
| Appearance | liquid |
| Water Solubility | H2O: soluble5mg/mL (clear solution, warmed) |
| Storage Condition | -20°C Freezer |
| Application | Duloxetine hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a Ki of 4.6 nM. |
| EINECS | 200-659-6 |
| HTC | 2934999090 |
| PubChem ID | 7848242 |
| SMILES | Cl.CNCCC(Oc1ccc2ccccc2c1)c3cccs3 |
| InChI | 1S/C18H19NOS.ClH/c1-19-11-10-17(18-7-4-12-21-18)20-16-9-8-14-5-2-3-6-15(14)13-16;/h2-9,12-13,17,19H,10-11H2,1H3;1H |
| InChI Key | QZIJQNJKJMLFKV-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/73693_1_136434_34_9.pdf |
| Bioactivity | Chemical & Physical Properties |
| Use of | Duloxetine hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) with Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD).Target: SNRIDuloxetine (sold under the brand names Cymbalta, Ariclaim, Xeristar, Yentreve, Duzela, Dulane) is a serotonin-norepinephrine reuptake inhibitor(SNRI) manufactured and marketed by Eli Lilly. It is prescribed for major depressive disorder and generalized anxiety disorder (GAD). Duloxetine also has approval for use in osteoarthiritis and musculoskeletal pain. Duloxetine failed the US approval for stress urinary incontinence amidst concerns over liver toxicity and suicidal events; however, it was approved for this indication in Europe, where it is recommended as an add-on medication in stress urinary incontinence instead of surgery. It can also relieve the symptoms of painful peripheral neuropathy, particularly diabetic neuropathy, and it is used to control the symptoms of fibromyalgia.The main uses of duloxetine are in major depressive disorder, general anxiety disorder, stress urinary incontinence, painful peripheral neuropathy,fibromyalgia, and chronic musculoskeletal pain associated with osteoarthritis and chronic lower back pain. It is being studied for various other indications. Properties Biological Activity Chemical & Physical Properties |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified Duloxetine Hydrochloride Modification Number: 4 |
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