CAS Number212844-53-6
SynonymsP01; 2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine NG-60; (2R)-2-[[6-(3-chloroanilino)-9-propan-2-ylpurin-2-yl]amino]-3-methylbutan-1-ol; NG-60; (2R)-2-({6-[(3-Chlorophenyl)amino]-9-isopropyl-9H-purin-2-yl}amino)-3-methyl-1-butanol; (2R)-2-({6-[(3-Chlorophenyl)amino]-9-isopropyl-9H-purin-2-yl}amino)-3-methylbutan-1-ol; Purvalanol A; Purv
Molecular FormulaC23H29O1N7Cl2
Molecular Weight490.43
Density1.3±0.1 g/cm3
Boiling Point590.5±60.0 °C at 760 mmHg
Appearancepowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 212844-53-6 |
| Catalog No. | 2A-9073141 |
| Chinese Name | Purvalanol A. |
| Synonyms | P01; 2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine NG-60; (2R)-2-[[6-(3-chloroanilino)-9-propan-2-ylpurin-2-yl]amino]-3-methylbutan-1-ol; NG-60; (2R)-2-({6-[(3-Chlorophenyl)amino]-9-isopropyl-9H-purin-2-yl}amino)-3-methyl-1-butanol; (2R)-2-({6-[(3-Chlorophenyl)amino]-9-isopropyl-9H-purin-2-yl}amino)-3-methylbutan-1-ol; Purvalanol A; Purv |
| Molecular Formula | C23H29O1N7Cl2 |
| Molecular Weight | 490.43 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 590.5±60.0 °C at 760 mmHg |
| Appearance | powder |
| Water Solubility | methylene chloride: 50 mg/mL, clear, colorless |
| Storage Condition | −20°C |
| Application | Purvalanol A is a potent CDK inhibitor with IC50 values of 4, 70, 35, 850 and 75 nM for cdc2-cyclin B, cdc2-cyclin B, cdk2-cyclin E, cdk4-cyclin D1 and cdk5-p35 respectively. |
| HTC | 2933990090 |
| PubChem ID | 602816 |
| MDL Number | MFCD16618395 |
| SMILES | CC(C)C(CO)Nc1nc(Nc2cccc(Cl)c2)c2ncn(C(C)C)c2n1 |
| InChI | InChI=1S/C19H25ClN6O/c1-11(2)15(9-27)23-19-24-17(22-14-7-5-6-13(20)8-14)16-18(25-19)26(10-21-16)12(3)4/h5-8,10-12,15,27H,9H2,1-4H3,(H2,22,23,24,25)/t15-/m0/s1 |
| InChI Key | PMXCMJLOPOFPBT-HNNXBMFYSA-N |
| MSDS | msds/73141_1_212844_53_6.pdf |
| Use of | Purvalanol A is a potent CDK inhibitor, which inhibits cdc2-cyclin B, cdk2-cyclin A, cdk2-cyclin E, cdk4-cyclin D1, and cdk5-p35 with IC50s of 4, 70, 35, 850, 75 nM, resepctively. Properties Biological Activity Chemical & Physical Properties Safety Info |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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