CAS Number13726-69-7
Synonymstrans-N-(tert-Butoxycarbonyl)-4-hydroxy-L-proline; BOC-HYP-OH; N-ter; trans-Boc-Hyp-OH; BOC-L-HYP-OH; BOC-HYP; N-BOC-L-Hydroxyproline; RARECHEM EM WB 0136; trans-N-tert-Butoxycarbonyl-4-hydroxy-l-proline; BOC-L-4-HYDROXYPROLINE; BOC-trans-4-hydroxy-L-proline; BOC-TRANS-HYP-OH; (2S,4R)-1-(tert-Butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid; MFCD00053370; trans-N-Boc-4-hydroxy-L-proline; BOC-HYDROXYPROLINE; (4R)-4-Hydroxy-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-proline; 4-Hydroxy-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-proline; 1-(tert-Butoxycarbonyl)-4-hydroxy-L-proline
Molecular FormulaC10H17NO5
Molecular Weight231.25
Purity≥98.0 (TLC)%
Density1.3±0.1 g/cm3
Boiling Point390.9±42.0 °C at 760 mmHg
Melting Point123-127 °C (lit.)
AppearanceSolid;White to Almost white powder to crystal
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 13726-69-7 |
| Catalog No. | 2A-9007302 |
| Chinese Name | Boc-L-羟脯氨酸 |
| Synonyms | trans-N-(tert-Butoxycarbonyl)-4-hydroxy-L-proline; BOC-HYP-OH; N-ter; trans-Boc-Hyp-OH; BOC-L-HYP-OH; BOC-HYP; N-BOC-L-Hydroxyproline; RARECHEM EM WB 0136; trans-N-tert-Butoxycarbonyl-4-hydroxy-l-proline; BOC-L-4-HYDROXYPROLINE; BOC-trans-4-hydroxy-L-proline; BOC-TRANS-HYP-OH; (2S,4R)-1-(tert-Butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid; MFCD00053370; trans-N-Boc-4-hydroxy-L-proline; BOC-HYDROXYPROLINE; (4R)-4-Hydroxy-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-proline; 4-Hydroxy-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-proline; 1-(tert-Butoxycarbonyl)-4-hydroxy-L-proline |
| Molecular Formula | C10H17NO5 |
| Molecular Weight | 231.25 |
| Purity | ≥98.0 (TLC) |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 390.9±42.0 °C at 760 mmHg |
| Melting Point | 123-127 °C (lit.) |
| Appearance | Solid;White to Almost white powder to crystal |
| Storage Condition | Sealed at room temperature, cool, ventilated and d |
| Application | Boc-Hyp-OH is a non-cleavable ADC linker for the synthesis of antibody drug conjugates (ADC). Boc Hyp OH is also a PROTAC linker based on alkyl chains and can be used to synthesize PROTAC[1][2] |
| HTC | 2933990090 |
| PubChem ID | 57647487 |
| MDL Number | MFCD00053370 |
| SMILES | CC(C)(C)OC(=O)N1C[C@H](O)C[C@H]1C(O)=O |
| InChI | 1S/C10H17NO5/c1-10(2,3)16-9(15)11-5-6(12)4-7(11)8(13)14/h6-7,12H,4-5H2,1-3H3,(H,13,14)/t6-,7+/m1/s1 |
| InChI Key | BENKAPCDIOILGV-RQJHMYQMSA-N |
| Beilstein/REAXYS | 4295484 |
| NACRES Code | NA.22 |
| eCl@ss | 32160406 |
| UNSPSC | 12352209 |
| Hazard Symbols | Transport |
| Safety Description | S22;S24/25 |
| MSDS | msds/7302_1_13726_69_7.pdf |
| Bioactivity | Boc-Hyp-OH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-Hyp-OH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2] Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker Target Non-cleavable In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. References [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 390.9±42.0 °C at 760 mmHg Melting Point 123-127 °C(lit.) Molecular Formula C10H17NO5 Molecular Weight 231.246 Flash Point 190.2±27.9 °C Exact Mass 231.110672 PSA 87.07000 LogP -0.71 Vapour Pressure 0.0±2.0 mmHg at 25°C Index of Refraction 1.531 InChIKey BENKAPCDIOILGV-RQJHMYQMSA-N SMILES CC(C)(C)OC(=O)N1CC(O)CC1C(=O)O Storage condition -20°C |
| Use of | Boc-Hyp-OH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-Hyp-OH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2] Properties Name Boc-L-Hydroxyproline Synonym More Synonyms Boc-Hyp-OH Biological Activity Description Boc-Hyp-OH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-Hyp-OH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2] Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker Non-cleavable In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. References [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. Chemical & Physical Properties Molecular Formula C10H17NO5 Exact Mass 231.110672 PSA 87.07000 LogP -0.71 Index of Refraction 1.531 InChIKey BENKAPCDIOILGV-RQJHMYQMSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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