CAS Number30652-11-0
Synonyms1,2-DIMETHYL-3-HYDROXYPYRID-4-ONE; 3-hydroxy-1,2-dimethyl-pyrid-4-one; 3-hydroxy-1,2-dimethylpyridin-4(1H)-one; Deferiprone; deferipnone; 3-HYDROXY-1,2-DIMETHYL-4(1H)-PYRIDONE; Ferriprox; 3-hydroxy-1,2-dimethyl-4-pyridinone; DMHP; DEFERIPRON; CP20; cp20(chelatingagent); 3-hydroxy-1,2-dimethyl-4-pyridone; 1,2-dimethyl-3-hydroxy-4(1H)-pyridinone; 3-Hydroxy-1,2-dimethyl-4(1H)-pyridinone; Kelfer; 1,2-dimethyl-3-hydroxy-4-pyridinone; 1,2-Dimethyl-3-hydroxy-4-pyridone; Deferione; DEFERIDONE; MFCD00134497
Molecular FormulaC7H9NO2
Molecular Weight139.15
Purity98%
Density1.2±0.1 g/cm3
Boiling Point232.7±40.0 °C at 760 mmHg
Melting Point272-275 °C (lit.)
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 30652-11-0 |
| Catalog No. | 2A-9000716 |
| Chinese Name | 去铁酮 |
| Synonyms | 1,2-DIMETHYL-3-HYDROXYPYRID-4-ONE; 3-hydroxy-1,2-dimethyl-pyrid-4-one; 3-hydroxy-1,2-dimethylpyridin-4(1H)-one; Deferiprone; deferipnone; 3-HYDROXY-1,2-DIMETHYL-4(1H)-PYRIDONE; Ferriprox; 3-hydroxy-1,2-dimethyl-4-pyridinone; DMHP; DEFERIPRON; CP20; cp20(chelatingagent); 3-hydroxy-1,2-dimethyl-4-pyridone; 1,2-dimethyl-3-hydroxy-4(1H)-pyridinone; 3-Hydroxy-1,2-dimethyl-4(1H)-pyridinone; Kelfer; 1,2-dimethyl-3-hydroxy-4-pyridinone; 1,2-Dimethyl-3-hydroxy-4-pyridone; Deferione; DEFERIDONE; MFCD00134497 |
| Molecular Formula | C7H9NO2 |
| Molecular Weight | 139.15 |
| Purity | 98 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 232.7±40.0 °C at 760 mmHg |
| Melting Point | 272-275 °C (lit.) |
| Appearance | powder |
| Water Solubility | soluble in hot water |
| Storage Condition | Keep the receptacle sealed, stored in a cool, dry |
| Application | Deferiprone is the only orally active iron chelator indicated for the treatment of transfusion-induced iron overload in thalassemia. |
| HTC | 2933399090 |
| PubChem ID | 24863630 |
| MDL Number | MFCD00134497 |
| SMILES | CN1C=CC(=O)C(O)=C1C |
| InChI | 1S/C7H9NO2/c1-5-7(10)6(9)3-4-8(5)2/h3-4,10H,1-2H3 |
| InChI Key | TZXKOCQBRNJULO-UHFFFAOYSA-N |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| Hazard Symbols | Transport |
| Risk Codes | R22;R36/37/38 |
| Safety Description | S26;S37/39 |
| MSDS | msds/716_1_30652_11_0.pdf |
| Bioactivity | Deferiprone is the only orally active iron-chelating drug to be used therapeutically in conditions of transfusional iron overload. Target：Deferiprone is an orphan drug designed and developed primarily by academic initiatives for the treatment of iron overload in thalassaemia. Deferiprone has been used in several other iron or other metal imbalance conditions and has prospects of wider clinical applications. Deferiprone has high affinity for iron and interacts with almost all the iron pools at the molecular, cellular, tissue and organ levels. Doses of 50-120 mg/kg/day appear to be effective in bringing patients to negative iron balance. Deferiprone increases urinary iron excretion, which mainly depends on the iron load of patients and the dose of the drug. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Cardiovascular Disease References [1]. Kontoghiorghes GJ, et al. Benefits and risks of deferiprone in iron overload in Thalassaemia and other conditions: comparison of epidemiological and therapeutic aspects with deferoxamine. Drug Saf. 2003;26(8):553-584. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 232.7±40.0 °C at 760 mmHg Melting Point 272-275 °C(lit.) Molecular Formula C7H9NO2 Molecular Weight 139.152 Flash Point 94.5±27.3 °C Exact Mass 139.063324 PSA 42.23000 LogP -0.22 Vapour Pressure 0.0±1.0 mmHg at 25°C Index of Refraction 1.565 InChIKey TZXKOCQBRNJULO-UHFFFAOYSA-N SMILES Cc1c(O)c(=O)ccn1C Storage condition -20°C Freezer |
| Use of | Properties Name deferiprone Synonym More Synonyms Deferiprone Biological Activity Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Cardiovascular Disease References [1]. Kontoghiorghes GJ, et al. Benefits and risks of deferiprone in iron overload in Thalassaemia and other conditions: comparison of epidemiological and therapeutic aspects with deferoxamine. Drug Saf. 2003;26(8):553-584. Chemical & Physical Properties Molecular Formula C7H9NO2 Exact Mass 139.063324 PSA 42.23000 LogP -0.22 Index of Refraction 1.565 InChIKey TZXKOCQBRNJULO-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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