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N-Dodecylimidazole

CAS Number4303-67-7

SynonymsImidazole,1-dodecyl; 1-n-dodecanylimidazole; 1H-Imidazole,1-dodecyl; dodecylimidazole; EINECS 224-314-4; N-dodecyl imidazole; 1-Laurylimidazole; 1-Dodecylimidazole; 1-Dodecyl-1H-imidazole; N-Laurylimidazole

Molecular FormulaC15H28N2

Molecular Weight236.4

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Cat. No.: 2A-9071115 Purity:
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Chemical & Physical Properties
CAS Number4303-67-7
Catalog No.2A-9071115
Chinese Name1-十二烷基咪唑
SynonymsImidazole,1-dodecyl; 1-n-dodecanylimidazole; 1H-Imidazole,1-dodecyl; dodecylimidazole; EINECS 224-314-4; N-dodecyl imidazole; 1-Laurylimidazole; 1-Dodecylimidazole; 1-Dodecyl-1H-imidazole; N-Laurylimidazole
Molecular FormulaC15H28N2
Molecular Weight236.4
Storage Condition2~8℃，Seal
Application1-Dodecylimidazole (N-Dodecylimidazole) is a lysosomally active detergent and cytotoxic agent. 1-Dodecylimidazole causes cell death through its acid-dependent accumulation in lysosomes, disruption of
HTC2933290090
PubChem ID454420
MDL NumberMFCD00278859
SMILESCCCCCCCCCCCCn1ccnc1
InChIInChI=1S/C15H28N2/c1-2-3-4-5-6-7-8-9-10-11-13-17-14-12-16-15-17/h12,14-15H,2-11,13H2,1H3
InChI KeyJMTFLSQHQSFNTE-UHFFFAOYSA-N
MSDSmsds/71115_1_4303_67_7.pdf
Use of1-Dodecylimidazole (N-Dodecylimidazole) is a lysosomotropic detergent and a cytotoxic agent. 1-Dodecylimidazole causes cell death by its acid-dependent accumulation in lysosomes, disruption of the lysosomal membrane, and releaseof cysteine proteases into the cytoplasm. 1-Dodecylimidazole has hypocholesterolaemic activity and broad-spectrum antifungal activity[1][2][3]. Properties Name 1-dodecylimidazole Synonym More Synonyms 1-Dodecylimidazole Biological Activity Description 1-Dodecylimidazole (N-Dodecylimidazole) is a lysosomotropic detergent and a cytotoxic agent. 1-Dodecylimidazole causes cell death by its acid-dependent accumulation in lysosomes, disruption of the lysosomal membrane, and releaseof cysteine proteases into the cytoplasm. 1-Dodecylimidazole has hypocholesterolaemic activity and broad-spectrum antifungal activity[1][2][3]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Anti-infection >> Fungal References [1]. Wilson PD, et al. A relationship between multidrug resistance and growth-state dependent cytotoxicity of the lysosomotropic detergent N-dodecylimidazole. Biochem Biophys Res Commun. 1991;176(3):1377-1382. [2]. Atkin SD, et al. The isolation of 2,3-oxidosqualene from the liver of rats treated with 1-dodecylimidazole, a novel hypocholesterolaemic agent. Biochem J. 1972;130(1):153-157. [3]. Firestone RA, et al. Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents. J Med Chem. 1987;30(8):1519-1521. [4]. Boyer MJ, et al. pH dependent cytotoxicity of N-dodecylimidazole: a compound that acquires detergent properties under acidic conditions. Br J Cancer. 1993;67(1):81-87. Chemical & Physical Properties Molecular Formula C15H28N2 Exact Mass 236.22500 PSA 17.82000 LogP 4.80400 InChIKey JMTFLSQHQSFNTE-UHFFFAOYSA-N Storage condition 2~8℃，Seal Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Imidazole, 1-dodecyl- CAS REGISTRY NUMBER : BEILSTEIN REFERENCE NO. : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C15-H28-N2 MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA MUTATION DATA TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Rodent - hamster Ovary DOSE/DURATION : REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 189,69,1987 Safety Information Hazard Codes Xi HS Code 2933290090 Synthetic Route CAS#:288-32-4 1-Bromododecane CAS#:143-15-7 1-Dodecylimidazole CAS#:4303-67-7 Literature: Kapitanov; Belousova; Shumeiko; Kostrikin; Prokop'Eva; Popov Russian Journal of Organic Chemistry, 2013 , vol. 49, # 9 p. 1291 - 1299 Zh. Org. Khim., 2013 , vol. 49, # 9 p. 1308 - 1316,9 CAS#:288-32-4 1-Iodododecane CAS#:4292-19-7 1-Dodecylimidazole CAS#:4303-67-7 Literature: Abate, Antonio; Petrozza, Annamaria; Cavallo, Gabriella; Lanzani, Guglielmo; Matteucci, Francesco; Bruce, Duncan W.; Houbenov, Nikolay; Metrangolo, Pierangelo; Resnati, Giuseppe Journal of Materials Chemistry A, 2013 , vol. 1, # 22 p. 6572 - 6578 CAS#:288-32-4 Methanesulfonic... CAS#:51323-71-8 1-Dodecylimidazole CAS#:4303-67-7 Literature: Qiao, Yunxiang; Hou, Zhenshan; Li, Huan; Hu, Yu; Feng, Bo; Wang, Xiangrui; Hua, Li; Huang, Qingfa Green Chemistry, 2009 , vol. 11, # 12 p. 1955 - 1960
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Summary 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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