| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1143-70-0 |
| Catalog No. | 2A-9070656 |
| Chinese Name | 尿石素A |
| Synonyms | 3,8-Dihydroxyurolithin; 3,8-Dihydroxy-6H-dibenzo<b,d>pyran-6-one; urolithin-A; urolithin B; Urolithin A |
| Molecular Formula | C13H8O4 |
| Molecular Weight | 228.20 |
| Purity | ≥97 (HPLC) |
| Density | 1.516g/cm3 |
| Boiling Point | 527.9ºC at 760 mmHg |
| Appearance | powder |
| Storage Condition | 0-10°C; avoid heating |
| Application | Urolithin A is an intestinal metabolite of ellagic acid with antioxidant and antiproliferative effects; inhibiting the growth of T24 and Caco-2 cells with IC50 values of 43.9 and 49 μM, respectively |
| HTC | 2914400090 |
| PubChem ID | 11694252 |
| MDL Number | MFCD20275235 |
| SMILES | OC1=CC=C(C(C=CC(O)=C2)=C2C(O3)=O)C3=C1 |
| InChI | 1S/C13H8O4/c14-7-1-3-9-10-4-2-8(15)6-12(10)17-13(16)11(9)5-7/h1-6,14-15H |
| InChI Key | RIUPLDUFZCXCHM-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/70656_1_1143_70_0.pdf |
| Use of | Properties Name 3,8-dihydroxybenzo[c]chromen-6-one Synonym More Synonyms Urolithin A Biological Activity Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Cancer In Vivo The volume of paw edema is reduced at 1 h after oral administration of urolithin A. In addition, plasma in treated mice exhibited significant oxygen radical antioxidant capacity (ORAC) scores with high plasma levels of the unconjugated form at 1 h after oral administration of urolithin A[4]. Cell Assay Human colon cancer cells HT-29 are treated for 24 and 48 h at 100 and 50 μM of Urolithin A and Iso Urolithin A aglycones and their glucuronide conjugates. Cell viability and proliferation are measured using a TC10 automated cell counter with the addition of Trypan blue for viability determination. IC50 values are determined by MTT assay[2]. Animal Admin Mice: Paw edema is induced in the right hind paw of ICR mice by the subcutaneous injection of 1% λ-carrageenan in pysiological saline (50 μL). The inflammation level is quantified by the volume of paw edema. Urolithin A dissolved in 0.5% carboxymethylcellulose suspension is orally administered to the mice at 1 or 6 h before carrageenan injection. The anti-inflammatory effects of urolithin A on carrageenan-induced edema in mice are analyzed[4]. References [2]. González-Sarrías A, et al. Antiproliferative activity of the ellagic acid-derived gut microbiota isourolithin A and comparison with its urolithin A isomer: the role of cell metabolism.Eur J Nutr. 2017 Mar;56(2):831-841. [4]. Ishimoto H, et al. In vivo anti-inflammatory and antioxidant properties of ellagitannin metabolite urolithin A. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5901-4. Chemical & Physical Properties Molecular Formula C13H8O4 Exact Mass 228.04200 PSA 70.67000 LogP 2.35740 Index of Refraction 1.717 InChIKey RIUPLDUFZCXCHM-UHFFFAOYSA-N Safety Information HS Code 2914400090 Synthetic Route 3,8-Dimethoxybe... Urolithin A Literature: Nealmongkol, Prattya; Tangdenpaisal, Kassrin; Sitthimonchai, Somkid; Ruchirawat, Somsak; Thasana, Nopporn Tetrahedron, 2013 , vol. 69, # 44 p. 9277 - 9283 Urolithin A 8-M... 35233-17-1 Urolithin A Literature: Cozza, Giorgio; Gianoncelli, Alessandra; Bonvini, Paolo; Zorzi, Elisa; Pasquale, Riccardo; Rosolen, Angelo; Pinna, Lorenzo A.; Meggio, Flavio; Zagotto, Giuseppe; Moro, Stefano ChemMedChem, 2011 , vol. 6, # 12 p. 2273 - 2286 2-Bromo-5-hydro... 58380-11-3 Urolithin A Literature: Pandey, Jaya; Jha, Ashok K.; Hajela Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 9 p. 2239 - 2249 Precursor & DownStream Precursor 9 CAS#:35233-17-1 Urolithin A 8-M... CAS#:58380-11-3 2-Bromo-5-hydro... CAS#:108-46-3 CAS#:62924-93-0 N,N-diethyl-3-m... DownStream 0 |
| Tax Rebate | 9.0% |
| Supervision | none |
| Transport Info | Product name: Summary 2914400090 other ketone-alcohols and ketone-aldehydes. Supervision conditions:None. VAT: 17.0%. Tax rebate rate:9.0%. MFN tariff:5.5%. General tariff:30.0% |
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