CAS Number23979-41-1
Synonymspiproxen; (+)-(S)-Naproxen; Anaprox; (R)-Naproxen; MFCD00870716; (2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid; (2R)-2-(6-Methoxy-2-naphthyl)propanoic acid; NAPRELAN; (2S)-2-(6-Methoxy-2-naphthyl)propanoic acid; (2S)-2-(6-Methoxynaphth-2-yl)propanoic acid; Naproxen; Apronax; EINECS 245-966-6; (+)-NAPROXEN; (S)-(+)-6-methoxy-α-methyl-2-naphthaleneacetic acid; (S)-(+)-Naproxen; ALEVE; (S)-naproxen; Naprosyn
Molecular FormulaCH3OC10H6CH(CH3)CO2H
Molecular Weight230.26
Purity98%
Density1.2±0.1 g/cm3
Boiling Point403.9±20.0 °C at 760 mmHg
Melting Point156-158ºC(lit.)
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 23979-41-1 |
| Catalog No. | 2A-9070463 |
| Chinese Name | (R)-萘普生 |
| Synonyms | piproxen; (+)-(S)-Naproxen; Anaprox; (R)-Naproxen; MFCD00870716; (2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid; (2R)-2-(6-Methoxy-2-naphthyl)propanoic acid; NAPRELAN; (2S)-2-(6-Methoxy-2-naphthyl)propanoic acid; (2S)-2-(6-Methoxynaphth-2-yl)propanoic acid; Naproxen; Apronax; EINECS 245-966-6; (+)-NAPROXEN; (S)-(+)-6-methoxy-α-methyl-2-naphthaleneacetic acid; (S)-(+)-Naproxen; ALEVE; (S)-naproxen; Naprosyn |
| Molecular Formula | CH3OC10H6CH(CH3)CO2H |
| Molecular Weight | 230.26 |
| Purity | 98 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 403.9±20.0 °C at 760 mmHg |
| Melting Point | 156-158ºC(lit.) |
| Storage Condition | 2-8°C |
| Application | l-Naproxen ((R)naproxen) is the enantiomer of (S)-naproxen. l-Naproxen can inhibit Cdc42 and Rac1 (EC50 are 96μM and 212μM respectively) and shows anti-tumor activity [1][2][3]. |
| HTC | 2918990090 |
| PubChem ID | 10256944 |
| SMILES | COc1ccc2cc(C(C)C(=O)O)ccc2c1 |
| InChI | InChI=1S/C14H14O3/c1-9(14(15)16)12-5-3-4-10-8-11(17-2)6-7-13(10)12/h3-9H,1-2H3,(H,15,16) |
| InChI Key | CMWTZPSULFXXJA-SECBINFHSA-N |
| Hazard Symbols | transportation |
| Bioactivity | l-Naproxen ((R)-Naproxen) is an enantiomer of (S)-Naproxen. l-Naproxen can inhibit Cdc42 and Rac1 (EC50=96 μM and 212 μM, respectively), and show anti-tumor activity[1][2][3]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Others >> Others In Vitro l-Naproxen (30-1000 μM; 2 h) inhibits Rac1 and Cdc42 activity selectively in cells[3]. l-Naproxen (0-300 μM; 48 h) inhibits migration of immortalized human ovarian cancer cells[3]. l-Naproxen (300 μM; 48 h) shows activity via a COX-independent mechanism[3]. Cell Viability Assay[3] Cell Line: HeLa cells Concentration: 30-1000 μM Incubation Time: 2 hour Result: Inhibited Rac1 and Cdc42 activity in a dose dependent manner with the EC50 values of 212 μM and 96 μM, respectively. Cell Migration Assay [3] Cell Line: OvCa429 and OvCa433 cells Concentration: 0-300 μM Incubation Time: 48 hour Result: Had a statistically significant inhibitory effect at 300 μM compared to untreated controls. Western Blot Analysis[3] Cell Line: OvCa433 cells Concentration: 300 μM Incubation Time: 48 hour Result: Exhibited higher levels of phosphorylated EGFR (pEGFR) and (pERK) compared to unstimulated controls. References [1]. Sonika Batra, et al. Enantiomeric Resolution of (RS)-Naproxen and Application of (S)- Naproxen in the Direct and Indirect Enantioseparation of Racemic Compounds by Liquid Chromatography: A Review. Curr Med Chem. 2017;24(8):758-780. [2]. M Iwaki, et al. Stereoselective disposition of naproxen glucuronide in the rat. Drug Metab Dispos. 1995 Oct;23(10):1099-103. [3]. Tudor I Oprea, et al. Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases. PLoS One. 2015 Nov 11;10(11):e0142182. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 403.9±20.0 °C at 760 mmHg Melting Point 156-158ºC(lit.) Molecular Formula C14H14O3 Molecular Weight 230.259 Flash Point 154.5±15.3 °C Exact Mass 230.094299 PSA 46.53000 LogP 3.00 Vapour Pressure 0.0±1.0 mmHg at 25°C Index of Refraction 1.609 InChIKey CMWTZPSULFXXJA-SECBINFHSA-N SMILES COc1ccc2cc(C(C)C(=O)O)ccc2c1 Storage condition 2-8°C |
| Use of | l-Naproxen ((R)-Naproxen) is an enantiomer of (S)-Naproxen. l-Naproxen can inhibit Cdc42 and Rac1 (EC50=96 μM and 212 μM, respectively), and show anti-tumor activity[1][2][3]. Properties Name (r)-naproxen Synonym More Synonyms Biological Activity Description l-Naproxen ((R)-Naproxen) is an enantiomer of (S)-Naproxen. l-Naproxen can inhibit Cdc42 and Rac1 (EC50=96 μM and 212 μM, respectively), and show anti-tumor activity[1][2][3]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Others >> Others References [1]. Sonika Batra, et al. Enantiomeric Resolution of (RS)-Naproxen and Application of (S)- Naproxen in the Direct and Indirect Enantioseparation of Racemic Compounds by Liquid Chromatography: A Review. Curr Med Chem. 2017;24(8):758-780. [2]. M Iwaki, et al. Stereoselective disposition of naproxen glucuronide in the rat. Drug Metab Dispos. 1995 Oct;23(10):1099-103. [3]. Tudor I Oprea, et al. Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases. PLoS One. 2015 Nov 11;10(11):e0142182. Chemical & Physical Properties Molecular Formula C14H14O3 Exact Mass 230.094299 PSA 46.53000 Index of Refraction 1.609 InChIKey CMWTZPSULFXXJA-SECBINFHSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 United Nations shipping name European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. ((R)-6-Methoxy-α-methylnaphthalene-1-acetic acid) IMDG: TOXIC SOLID, ORGANIC, N.O.S. ((R)-6-Methoxy-α-methylnaphthalene-1-acetic acid) International air transport hazard regulations: Toxic solid, organic, n.o.s. ((R)-6-Methoxy-α-methylnaphthalene-1-acetic acid) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
| Related Products in Pharmaceutical Intermediates | ||
|---|---|---|
| 5,7-Dichloroimidazo[1,2-a]pyrimidine | 57473-32-2 | 2A-9070334 |
| Imidazo[1,2-a]pyridine-2-methanol | 82090-52-6 | 2A-9070342 |
| Methyl(2R,4R)-4-aminopyrrolidine-2-carboxylate,N1-BOCprotected | 1018667-18-9 | 2A-9070347 |
| 2-(4-piperidinyl)-1H-benzimidazole | 38385-95-4 | 2A-9070431 |
| 3-(Bromomethyl)quinoxaline-2(1H)-one | 62235-61-4 | 2A-9070459 |
| methylimidazo[1,2-a]pyrazine-8-carboxylate | 850349-42-7 | 2A-9070482 |
| (1R,3S,4S)-N-Boc-2-azabicyclo[2.2.1]heptane-3-carboxylicacid | 291775-59-2 | 2A-9070497 |
| (R)-(-)-3-fluoropyrrolidinehydrochloride | 136725-55-8 | 2A-9070550 |
| 8-Bromo-imidazo[1,2-a]pyridine-2-carboxylicacid | 1026201-45-5 | 2A-9070559 |
| (2R,5S)-Dimethyl-1-Boc-piperazine | 194032-41-2 | 2A-9070571 |
| Browse all Pharmaceutical Intermediates products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS