CAS Number490-31-3
SynonymsRobinetin; Norkanugin; 3,7,3',4',5'-pentahydroxyflavonol; 3,7,3',4',5'-pentahydroxyflavone; 3,7-Dihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chromen-4-one; 3,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)chromen-4-one; 5-Hydroxyfisetin; EINECS 207-709-6; 3,3',4',5',7-Pentahydroxyflavone
Molecular FormulaC15H10O7
Molecular Weight302.24
Purity≥95.0 (HPLC)%
Density1.8±0.1 g/cm3
Boiling Point669.9±55.0 °C at 760 mmHg
Melting Point326-328ºC
Appearanceyellow powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 490-31-3 |
| Catalog No. | 2A-9069002 |
| Chinese Name | 洋槐黄素 |
| Synonyms | Robinetin; Norkanugin; 3,7,3',4',5'-pentahydroxyflavonol; 3,7,3',4',5'-pentahydroxyflavone; 3,7-Dihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chromen-4-one; 3,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)chromen-4-one; 5-Hydroxyfisetin; EINECS 207-709-6; 3,3',4',5',7-Pentahydroxyflavone |
| Molecular Formula | C15H10O7 |
| Molecular Weight | 302.24 |
| Purity | ≥95.0 (HPLC) |
| Density | 1.8±0.1 g/cm3 |
| Boiling Point | 669.9±55.0 °C at 760 mmHg |
| Melting Point | 326-328ºC |
| Appearance | yellow powder |
| Storage Condition | 2-8℃, dry, sealed |
| Application | Robinetin (3,3',4',5',7-Pentahydroxyflavone) is a natural flavone with significant "two-color" intrinsic fluorescence properties and antifungal, antiviral, antibacterial, antimutagenic and antioxidant |
| HTC | 2932999099 |
| MDL Number | MFCD00016783 |
| SMILES | [o]1c2c([c](c(c1c3cc(c(c(c3)O)O)O)O)=O)ccc(c2)O |
| InChI | 1S/C15H10O7/c16-7-1-2-8-11(5-7)22-15(14(21)12(8)19)6-3-9(17)13(20)10(18)4-6/h1-5,16-18,20-21H |
| InChI Key | SOEDEYVDCDYMMH-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/69002_1_490_31_3.pdf |
| Use of | Robinetin (3,3',4',5',7-Pentahydroxyflavone), a naturally occurring flavonoid with remarkable 'two color' intrinsic fluorescence properties, has antifungal, antiviral, antibacterial, antimutagenesis, and antioxidant activity. Robinetin also can inhibit lipid peroxidation and protein glycosylation[1][2][3][4][5]. Properties Name robinetin Synonym More Synonyms 5-Hydroxyfisetin Biological Activity Description Robinetin (3,3',4',5',7-Pentahydroxyflavone), a naturally occurring flavonoid with remarkable 'two color' intrinsic fluorescence properties, has antifungal, antiviral, antibacterial, antimutagenesis, and antioxidant activity. Robinetin also can inhibit lipid peroxidation and protein glycosylation[1][2][3][4][5]. Related Catalog Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal Signaling Pathways >> Metabolic Enzyme/Protease >> HIV Integrase Signaling Pathways >> Anti-infection >> Bacterial In Vitro Robinetin (0.1-10 μM; 1 h) inhibits HIV integrase cleavage and integration in a dose-dependent manner[1]. Robinetin inhibits the DNA synthesis in Proteus vulgaris, and the RNA synthesis in S. aureus[2]. Robinetin (100-200 or 25 μM; 1 or 72 h) inhibits egg yolk phosphatidylcholine (EYPC) membrane lipid peroxidation and hemoglobin A (HbA) glycosylation with high efficiency[3]. Robinetin exhibits photo-induced excited-state intramolecular proton transfer resulting in 'two color' (in 'blue-violet' and 'yellow-green' regions) fluorescence characteristic of flavonols, the relative contributions between the two colors being strongly modulated by the local environment of the fluorophore[3]. References [1]. Fesen MR, et, al. Inhibition of HIV-1 integrase by flavones, caffeic acid phenethyl ester (CAPE) and related compounds. Biochem Pharmacol. 1994 Aug 3;48(3):595-608. [2]. Cushnie TPT, et, al. Antimicrobial activity of flavonoids. Int J Antimicrob Agents. 2005 Nov;26(5):343-56. [3]. Chaudhuri S, et, al. Binding of the bioflavonoid robinetin with model membranes and hemoglobin: Inhibition of lipid peroxidation and protein glycosylation. J Photochem Photobiol B. 2010 Jan 21;98(1):12-9. [4]. Birt DF, et, al. Anti-mutagenesis and anti-promotion by apigenin, robinetin and indole-3-carbinol. Carcinogenesis. 1986 Jun;7(6):959-63. [5]. Manrique-de-la-Cuba MF, et, al. Theoretical study of the antioxidant capacity of the flavonoids present in the Annona muricata (Soursop) leaves. J Mol Model. 2019 Jun 25;25(7):200. Chemical & Physical Properties Molecular Formula C15H10O7 Exact Mass 302.042664 PSA 131.36000 Index of Refraction 1.823 InChIKey SOEDEYVDCDYMMH-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Flavone, 3,3',4',5',7-pentahydroxy- CAS REGISTRY NUMBER : BEILSTEIN REFERENCE NO. : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C15-H10-O7 MOLECULAR WEIGHT : WISWESSER LINE NOTATION : T66 BO EVJ CR CQ DQ EQ& DQ IQ HEALTH HAZARD DATA ACUTE TOXICITY DATA MUTATION DATA TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Microorganism - not otherwise specified DOSE/DURATION : REFERENCE : PYTCAS Phytochemistry. An International Journal of Plant Biochemistry. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1961- Volume(issue)/page/year: 26,2231,1987 Safety Information Hazard Codes Xi Risk Phrases R22 Safety Phrases 22-45 RIDADR UN 2811 HS Code 2932999099 Precursor & DownStream Precursor 9 CAS#:354119-95-2 7-benzyloxy-3-h... CAS#:29682-12-0 1-(4-(Benzyloxy... CAS#:89-84-9 2,4-Dihydroxyac... CAS#:20979-43-5 7-Hydroxy-3,3',... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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