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Home > Products > Pharmaceuticals & Life Science > Pharmaceutical Intermediates > 1-Piperidinecarboxamide,4-[2-[4-[(11R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]-1-piperidinyl]-2-oxoethyl]-
1-Piperidinecarboxamide,4-[2-[4-[(11R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]-1-piperidinyl]-2-oxoethyl]- structure, CAS 193275-84-2

1-Piperidinecarboxamide,4-[2-[4-[(11R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]-1-piperidinyl]-2-oxoethyl]-

CAS Number193275-84-2

Synonyms1-PiperidinecarboxaMide,4-[2-[4-[(11R)-3,10-dibroMo-8-chloro-6; Lonafarnib; LonafarMib; Lonafarnib [usan]; Sarasar

Molecular FormulaC27H31Br2ClN4O2

Molecular Weight638.82

Purity≥98 (HPLC)%

Density1.5±0.1 g/cm3

Boiling Point710.4±70.0 °C at 760 mmHg

Melting Point214.5-215.9° (monohydrate); mp 222-223°

Flash Point

Appearancepowder

EINECS

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Symbol

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Cat. No.: 2A-9068403 Purity: ≥98 (HPLC)%
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Quality Control of [ 193275-84-2 ] Purity: ≥98 (HPLC)% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number193275-84-2
Catalog No.2A-9068403
Chinese Name氯那法尼
Synonyms1-PiperidinecarboxaMide,4-[2-[4-[(11R)-3,10-dibroMo-8-chloro-6; Lonafarnib; LonafarMib; Lonafarnib [usan]; Sarasar
Molecular FormulaC27H31Br2ClN4O2
Molecular Weight638.82
Purity≥98 (HPLC)
Density1.5±0.1 g/cm3
Boiling Point710.4±70.0 °C at 760 mmHg
Melting Point214.5-215.9° (monohydrate); mp 222-223°
Appearancepowder
Storage Condition-20℃
ApplicationLonafarnib is an orally active farnesyl protein transferase (FPTase) inhibitor against H-ras, K-ras and N-ras with IC50 of 1.9 nM, 5.2 nM and 2.8 nM respectively.
PubChem ID329825894
MDL NumberMFCD06795138
SMILESO=C(N)N(CC1)CCC1CC(N2CCC([C@H]3C(N=CC(Br)=C4)=C4CCC5=C3C(Br)=CC(Cl)=C5)CC2)=O
InChI1S/C27H31Br2ClN4O2/c28-20-12-19-2-1-18-13-21(30)14-22(29)24(18)25(26(19)32-15-20)17-5-9-33(10-6-17)23(35)11-16-3-7-34(8-4-16)27(31)36/h12-17,25H,1-11H2,(H2,31,36)/t25-/m1/s1
InChI KeyDHMTURDWPRKSOA-RUZDIDTESA-N
NACRES CodeNA.77
UNSPSC12352200
MSDSmsds/68403_1_193275_84_2.pdf
Transport InfoProduct Name: Lonafarni
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