CAS Number525-79-1
Synonyms6-Furfurylaminopurine,N6-Furfuryladenine; N-(2-Furylmethyl)-7H-purin-6-amine; N-furfuryl-7H-purin-6-amine; N-(2-Furylmethyl)-3H-purin-6-amine; N-(Furan-2-ylmethyl)-1H-purin-6-amine; MFCD00075757; T56 BM DN FN HNJ IM1- BT5OJ; cytokinin; fap; EINECS 208-382-2; N-(2-furanylmethyl)-1H-purin-6-amine; QUINETINE; 6-(Furfurylamino)purine; Kinetin; N-Furfuryl-Adenine; Kiniten; N6-Furfuryladenine; N-(Furan-2-ylmethyl)-9H-purin-6-amine; 6-Furfurylaminopurine; KINETINE; N6-(2-Furylmethyl)-9H-purin-6-amine; N(Sup6)-Furfuryladenine; N-(furan-2-ylmethyl)-7H-purin-6-amine; N-Furfuryladenine; Kinetina; T56 BM DN GN INJ FM1- BT5OJ
Molecular FormulaC10H9N5O
Molecular Weight215.21
Purity≥98 (TLC and HPLC)%
Density1.6±0.1 g/cm3
Boiling Point367.6±52.0 °C at 760 mmHg
Melting Point264-270 °C (dec.) (lit.)
Appearanceamorphous powder
EINECS208-382-2
Symbol
Signal WordWarning
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| Chemical & Physical Properties | |
|---|---|
| CAS Number | 525-79-1 |
| Catalog No. | 2A-9006834 |
| Chinese Name | 6-糠氨基嘌呤 |
| Synonyms | 6-Furfurylaminopurine,N6-Furfuryladenine; N-(2-Furylmethyl)-7H-purin-6-amine; N-furfuryl-7H-purin-6-amine; N-(2-Furylmethyl)-3H-purin-6-amine; N-(Furan-2-ylmethyl)-1H-purin-6-amine; MFCD00075757; T56 BM DN FN HNJ IM1- BT5OJ; cytokinin; fap; EINECS 208-382-2; N-(2-furanylmethyl)-1H-purin-6-amine; QUINETINE; 6-(Furfurylamino)purine; Kinetin; N-Furfuryl-Adenine; Kiniten; N6-Furfuryladenine; N-(Furan-2-ylmethyl)-9H-purin-6-amine; 6-Furfurylaminopurine; KINETINE; N6-(2-Furylmethyl)-9H-purin-6-amine; N(Sup6)-Furfuryladenine; N-(furan-2-ylmethyl)-7H-purin-6-amine; N-Furfuryladenine; Kinetina; T56 BM DN GN INJ FM1- BT5OJ |
| Molecular Formula | C10H9N5O |
| Molecular Weight | 215.21 |
| Purity | ≥98 (TLC and HPLC) |
| Density | 1.6±0.1 g/cm3 |
| Boiling Point | 367.6±52.0 °C at 760 mmHg |
| Melting Point | 264-270 °C (dec.) (lit.) |
| Appearance | amorphous powder |
| Water Solubility | H2O: soluble |
| Storage Condition | Store in a cool, dry and well-ventilated warehouse |
| Application | Kinetin (N6-furfuryladenine) is a plant growth hormone involved in cell division. |
| EINECS | 208-382-2 |
| HTC | 29349990 |
| PubChem ID | 24896230 |
| MDL Number | MFCD00075757 |
| SMILES | C(Nc1ncnc2[nH]cnc12)c3ccco3 |
| InChI | 1S/C10H9N5O/c1-2-7(16-3-1)4-11-9-8-10(13-5-12-8)15-6-14-9/h1-3,5-6H,4H2,(H2,11,12,13,14,15) |
| InChI Key | QANMHLXAZMSUEX-UHFFFAOYSA-N |
| Beilstein/REAXYS | 21703 |
| NACRES Code | NA.72 |
| UNSPSC | 10171502 |
| Hazard Symbols | Transport |
| MSDS | msds/6834_1_525_79_1.pdf |
| Bioactivity | Kinetin (N6-furfuryladenine) belongs to a group of plant growth hormones involved in cell division, differentiation and other physiological processes.IC50 Value: Target:Kinetin is one of the widely used components in numerous skin care cosmetics and cosmeceuticals, such as Valeant products kinerase. Recently, kinetin has the potential to be a treatment for the human splicing disease familial dysautonomia.in vitro: Kinetin-induced cell death reflected by the morphological changes of nuclei including their invagination, volume increase, chromatin condensation and degradation as well as formation of micronuclei showed by AO/EB and 4,6-diamidino-2-phenylindol staining was accompanied by changes including increase in conductivity of cell electrolytes secreted to culture media, decrease in the number of the G1- and G2-phase cells and appearance of fraction of hypoploid cells as the effect of DNA degradation without ladder formation [1]. The plant cytokinin kinetin dramatically increases exon 20 inclusion in RNA isolated from cultured FD cells [3].in vivo: Subjects received 23.5 mg/Kg/d for 28 d. An increase in WT IKBKAP mRNA expression in leukocytes was noted after 8 d in six of eight individuals; after 28 d, the mean increase compared with baseline was significant (p = 0.002) [2].Toxicity: On mice with leukaemia P388, kinetin has no effect on the tumour growth, and it appears to be toxic at the dose of 25 mg/kg [4]. Related Catalog Signaling Pathways >> Others >> Others Natural Products >> Alkaloid Research Areas >> Neurological Disease References [1]. Kunikowska A, et al. Kinetin induces cell death in root cortex cells of Vicia faba ssp. minor seedlings. Protoplasma. 2013 Aug;250(4):851-61. [2]. Axelrod FB, et al. Kinetin improves IKBKAP mRNA splicing in patients with familial dysautonomia. Pediatr Res. 2011 Nov;70(5):480-3. [3]. Hims MM, et al. Therapeutic potential and mechanism of kinetin as a treatment for the human splicing disease familial dysautonomia. J Mol Med (Berl). 2007 Feb;85(2):149-61. [4]. Griffaut B, et al. Cytotoxic effects of kinetin riboside on mouse, human and plant tumour cells. Int J Biol Macromol. 2004 Aug;34(4):271-5. Chemical & Physical Properties Density 1.6±0.1 g/cm3 Boiling Point 367.6±52.0 °C at 760 mmHg Melting Point 269-271 °C (dec.)(lit.) Molecular Formula C10H9N5O Molecular Weight 215.211 Flash Point 176.1±30.7 °C Exact Mass 215.080704 PSA 79.63000 LogP -0.56 Vapour Pressure 0.0±0.8 mmHg at 25°C Index of Refraction 1.774 InChIKey QANMHLXAZMSUEX-UHFFFAOYSA-N SMILES c1coc(CNc2ncnc3nc[nH]c23)c1 Storage condition −20°C Water Solubility H2O: soluble |
| Use of | Properties Articles47 Name kinetin Synonym More Synonyms 6-(Furfurylamino)purine Biological Activity Related Catalog Signaling Pathways >> Others >> Others Natural Products >> Alkaloid Research Areas >> Neurological Disease References [1]. Kunikowska A, et al. Kinetin induces cell death in root cortex cells of Vicia faba ssp. minor seedlings. Protoplasma. 2013 Aug;250(4):851-61. [2]. Axelrod FB, et al. Kinetin improves IKBKAP mRNA splicing in patients with familial dysautonomia. Pediatr Res. 2011 Nov;70(5):480-3. [3]. Hims MM, et al. Therapeutic potential and mechanism of kinetin as a treatment for the human splicing disease familial dysautonomia. J Mol Med (Berl). 2007 Feb;85(2):149-61. [4]. Griffaut B, et al. Cytotoxic effects of kinetin riboside on mouse, human and plant tumour cells. Int J Biol Macromol. 2004 Aug;34(4):271-5. Chemical & Physical Properties Molecular Formula C10H9N5O Exact Mass 215.080704 PSA 79.63000 LogP -0.56 Index of Refraction 1.774 InChIKey QANMHLXAZMSUEX-UHFFFAOYSA-N Water Solubility H2O: soluble |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip. |
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