CAS Number36839-55-1
SynonymsEthylene Glycol Bis(2-iodoethyl) Ether; 1,2-BIS(2-IODOETHOXY)ETHANE; MFCD00075008
Molecular FormulaICH2CH2OCH2CH2OCH2CH2I
Molecular Weight369.97
Purity96%
Density2.028 g/mL at 25 °C(lit.)
Boiling Point293.5ºC at 760 mmHg
Appearanceliquid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 36839-55-1 |
| Catalog No. | 2A-9000681 |
| Chinese Name | 1,2-双(2-碘乙氧基)乙烷 |
| Synonyms | Ethylene Glycol Bis(2-iodoethyl) Ether; 1,2-BIS(2-IODOETHOXY)ETHANE; MFCD00075008 |
| Molecular Formula | ICH2CH2OCH2CH2OCH2CH2I |
| Molecular Weight | 369.97 |
| Purity | 96 |
| Density | 2.028 g/mL at 25 °C(lit.) |
| Boiling Point | 293.5ºC at 760 mmHg |
| Appearance | liquid |
| Storage Condition | Keep the receptacle sealed, stored in a cool, dry |
| Application | 1,2-Bis(2-iodoethoxy)ethane is a PROTAC linker and belongs to the PEG class. 1,2-Bis(2-iodoethoxy)ethane can be used in the synthesis of MT802 (HY-122562) and SJF620 (HY-133137). MT-802 and SJF620 are |
| HTC | 2909199090 |
| PubChem ID | 24860131 |
| MDL Number | MFCD00075008 |
| SMILES | ICCOCCOCCI |
| InChI | 1S/C6H12I2O2/c7-1-3-9-5-6-10-4-2-8/h1-6H2 |
| InChI Key | BCAGFJXMCZSAHD-UHFFFAOYSA-N |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| Hazard Symbols | Transport |
| Risk Codes | 36/37/38 |
| Safety Description | 26-37/39 |
| MSDS | msds/681_1_36839_55_1.pdf |
| Bioactivity | 1,2-Bis(2-iodoethoxy)ethane is a PEG-based PROTAC linker. 1,2-Bis(2-iodoethoxy)ethane can be used in the synthesis of MT802 (HY-122562) and SJF620 (HY-133137). MT-802 and SJF620 are potent PROTAC BTK degraders with DC50s of 1 nM and 7.9 nM, respectively[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker Target PEGs In Vitro 1,2-Bis(2-iodoethoxy)ethane is a PROTAC linker, which refers to the PEG composition. 1,2-Bis(2-iodoethoxy)ethane can be used in the synthesis of a series of PROTACs, such as MT802 (HY-122562) and SJF620 (HY-133137). PROTAC MT802（HY-122562） has a ligand specific for BTK, and a ligand specific to a E3 ligase cereblon (CRBN) connected by polyethylene glycol (PEG) linker 1,2-Bis(2-iodoethoxy)ethane[1]. References [1]. Jaime-Figueroa S, et al. Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties. 2020 Feb 1;30(3):126877. Chemical & Physical Properties Density 2.028 g/mL at 25 °C(lit.) Boiling Point 293.5ºC at 760 mmHg Molecular Formula C6H12I2O2 Molecular Weight 369.96700 Flash Point >230 °F Exact Mass 369.89300 PSA 18.46000 LogP 1.88960 Index of Refraction n20/D 1.572(lit.) InChIKey BCAGFJXMCZSAHD-UHFFFAOYSA-N SMILES ICCOCCOCCI |
| Use of | 1,2-Bis(2-iodoethoxy)ethane is a PEG-based PROTAC linker. 1,2-Bis(2-iodoethoxy)ethane can be used in the synthesis of MT802 (HY-122562) and SJF620 (HY-133137). MT-802 and SJF620 are potent PROTAC BTK degraders with DC50s of 1 nM and 7.9 nM, respectively[1]. Properties Name 1,2-Bis(2-iodoethoxy)ethane Synonym More Synonyms Iodo-PEG3-Iodide Biological Activity Description 1,2-Bis(2-iodoethoxy)ethane is a PEG-based PROTAC linker. 1,2-Bis(2-iodoethoxy)ethane can be used in the synthesis of MT802 (HY-122562) and SJF620 (HY-133137). MT-802 and SJF620 are potent PROTAC BTK degraders with DC50s of 1 nM and 7.9 nM, respectively[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker References [1]. Jaime-Figueroa S, et al. Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties. 2020 Feb 1;30(3):126877. Chemical & Physical Properties Molecular Formula C6H12I2O2 Exact Mass 369.89300 PSA 18.46000 LogP 1.88960 InChIKey BCAGFJXMCZSAHD-UHFFFAOYSA-N SMILES ICCOCCOCCI |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 5.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 96.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: No dangerous goods IMDG Code: No dangerous goods International Air Transport Dangerous Regulations: No dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special precautions for users No data available |
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