CAS Number53948-10-0
Synonyms3,4,6-trimethoxyaristolactame; aristolactam A II; Aristololactam B III; 1,2,9-Trimethoxydibenzo[cd,f]indol-4(5H)-one; aristololactam A-II; Dibenz(cd,f)indol-4(5H)-one,2-hydroxy-1-methoxy; aristolactam BIII
Molecular FormulaC18H15NO4
Molecular Weight309.316
Density1.3±0.1 g/cm3
Boiling Point462.8±45.0 °C at 760 mmHg
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 53948-10-0 |
| Catalog No. | 2A-9067717 |
| Chinese Name | 马兜铃内酰胺BIII |
| Synonyms | 3,4,6-trimethoxyaristolactame; aristolactam A II; Aristololactam B III; 1,2,9-Trimethoxydibenzo[cd,f]indol-4(5H)-one; aristololactam A-II; Dibenz(cd,f)indol-4(5H)-one,2-hydroxy-1-methoxy; aristolactam BIII |
| Molecular Formula | C18H15NO4 |
| Molecular Weight | 309.316 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 462.8±45.0 °C at 760 mmHg |
| Application | Aristolactam BIII is a potent DYRK1A inhibitor that inhibits the kinase activity of DYRK1A in vitro (IC50=9.67 nM). Aristolactam BIII reverses proliferation defects in DYRK1A transgenic (TG) mouse-der |
| HTC | 2933990090 |
| SMILES | COc1ccc2cc3c4c(cc(OC)c(OC)c4c2c1)C(=O)N3 |
| InChI Key | OQKGOEOSXXHWFQ-UHFFFAOYSA-N |
| Use of | Aristolactam BIII is a potent DYRK1A inhibitor and inhibits the kinase activity of DYRK1A in vitro (IC50= 9.67 nM. Aristolactam BIII rescues the proliferative defects of DYRK1A transgenic (TG) mouse-derived fibroblasts and neurological and phenotypic defects of DS-like Drosophila models[1]. Properties Name 1,2,9-Trimethoxydibenzo[cd,f]indol-4(5H)-one Synonym More Synonyms Biological Activity Description Aristolactam BIII is a potent DYRK1A inhibitor and inhibits the kinase activity of DYRK1A in vitro (IC50= 9.67 nM. Aristolactam BIII rescues the proliferative defects of DYRK1A transgenic (TG) mouse-derived fibroblasts and neurological and phenotypic defects of DS-like Drosophila models[1]. Related Catalog Signaling Pathways >> Protein Tyrosine Kinase/RTK >> DYRK Research Areas >> Inflammation/Immunology References [1]. Miri Choi, et al. Aristolactam BIII, a naturally derived DYRK1A inhibitor, rescues Down syndrome-related phenotypes. Phytomedicine. 2021 Nov:92:153695. Chemical & Physical Properties Molecular Formula C18H15NO4 Exact Mass 309.100098 PSA 60.28000 Index of Refraction 1.681 InChIKey OQKGOEOSXXHWFQ-UHFFFAOYSA-N Safety Information HS Code 2933990090 Synthetic Route 4-bromo-5,6-dim... CAS#:1042722-42-8 5-Methoxy-2-for... CAS#:40138-18-9 1,2,9-Trimethox... CAS#:53948-10-0 Literature: Choi, Young Lok; Kim, Joa Kyum; Choi, Sang-Un; Min, Yong-Ki; Bae, Myung-Ae; Kim, Bum Tae; Heo, Jung-Nyoung Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 11 p. 3036 - 3040 (E)-N-(4'-metho... CAS#:128580-96-1 1,2,9-Trimethox... CAS#:53948-10-0 Literature: Estevez, Juan C.; Estevez, Ramon J.; Castedo, Luis Tetrahedron, 1995 , vol. 51, # 39 p. 10801 - 10810 2-bromo-4,5-dim... CAS#:128604-36-4 1,2,9-Trimethox... CAS#:53948-10-0 Literature: Estevez; Guitian; Villaverde; Castedo Tetrahedron Letters, 1989 , vol. 30, # 42 p. 5785 - 5786 Precursor & DownStream Precursor 3 CAS#:1042722-42-8 4-bromo-5,6-dim... CAS#:40138-18-9 5-Methoxy-2-for... CAS#:55-81-2 4-Methoxyphenyl... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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