CAS Number2169-44-0
SynonymsRogersine; lauroscholtzine; N-Methyllaurotetanine; (6aS)-1,2,10-Trimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-9-ol
Molecular FormulaC20H23NO4
Molecular Weight341.401
Density1.2±0.1 g/cm3
Boiling Point506.1±50.0 °C at 760 mmHg
Melting Point102.5°C
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 2169-44-0 |
| Catalog No. | 2A-9067380 |
| Chinese Name | 波尔定碱 2-甲醚 |
| Synonyms | Rogersine; lauroscholtzine; N-Methyllaurotetanine; (6aS)-1,2,10-Trimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-9-ol |
| Molecular Formula | C20H23NO4 |
| Molecular Weight | 341.401 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 506.1±50.0 °C at 760 mmHg |
| Melting Point | 102.5°C |
| Application | Laurylazine (N-methyllauryl alcohol) is a natural alkaloid and a 5-HT1A receptor agonist [1]. |
| HTC | 2933990090 |
| SMILES | COc1cc2c(cc1O)CC1c3c(cc(OC)c(OC)c3-2)CCN1C |
| InChI | InChI=1S/C20H23NO4/c1-21-6-5-11-9-17(24-3)20(25-4)19-13-10-16(23-2)15(22)8-12(13)7-14(21)18(11)19/h8-10,14,22H,5-7H2,1-4H3/t14-/m0/s1 |
| InChI Key | ZFLRVRLYWHNAEC-AWEZNQCLSA-N |
| Use of | Lauroscholtzine (N-Methyllaurotetanine), a natural alkaloid, is a 5-HT1A receptor agonist[1]. Properties Name (6aS)-1,2,10-trimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-9-ol Synonym More Synonyms lauroscholtzine Biological Activity Description Lauroscholtzine (N-Methyllaurotetanine), a natural alkaloid, is a 5-HT1A receptor agonist[1]. Related Catalog Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor References [1]. Sudharshan Madapa, et al. Semisynthetic Studies on and Biological Evaluation of N-Methyllaurotetanine Analogues as Ligands for 5-HT Receptors. J Nat Prod. 2015 Apr 24;78(4):722-9. Chemical & Physical Properties Molecular Formula C20H23NO4 Exact Mass 341.162720 PSA 51.16000 Index of Refraction 1.604 InChIKey ZFLRVRLYWHNAEC-AWEZNQCLSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : 6a-alpha-Aporphin-9-ol, 1,2,10-trimethoxy- CAS REGISTRY NUMBER : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C20-H23-N-O4 MOLECULAR WEIGHT : WISWESSER LINE NOTATION : T C6666 1A Q KN&TT&J EO1 FQ K1 PO1 QO1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Cardiac - change in rate Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes REFERENCE : APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 38,537,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Cardiac - change in rate Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes REFERENCE : APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 38,537,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Cardiac - change in rate Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes REFERENCE : APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 38,537,1980 Safety Information HS Code 2933990090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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