CAS Number480-81-9
SynonymsJacodine; a-Longilobine; α-Longilobine; (15Z)-12-Hydroxy-13,19-didehydrosenecionan-11,16-dione; seneciphylline
Molecular FormulaC18H23NO5
Molecular Weight333.38
Density1.3±0.1 g/cm3
Boiling Point577.7±50.0 °C at 760 mmHg
Melting Point217ºC
Appearancewhite powder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 480-81-9 |
| Catalog No. | 2A-9067159 |
| Chinese Name | 千里光菲灵碱 |
| Synonyms | Jacodine; a-Longilobine; α-Longilobine; (15Z)-12-Hydroxy-13,19-didehydrosenecionan-11,16-dione; seneciphylline |
| Molecular Formula | C18H23NO5 |
| Molecular Weight | 333.38 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 577.7±50.0 °C at 760 mmHg |
| Melting Point | 217ºC |
| Appearance | white powder |
| Storage Condition | 2-8℃ |
| Packaging | III |
| Application | Seneciphylline is a toxic pyrrolidine alkaloid found in the Senecio plant. Seneciphylline significantly increased the activities of epoxide hydrase and glutathione-S-transferase, but resulted in a dec |
| MDL Number | C18H23NO5 |
| SMILES | C=C1CC(=CC)C(=O)OC2CCN3CC=C(COC(=O)C1(C)O)C23 |
| InChI | InChI=1S/C18H23NO5/c1-4-12-9-11(2)18(3,22)17(21)23-10-13-5-7-19-8-6-14(15(13)19)24-16(12)20/h4-5,14-15,22H,2,6-10H2,1,3H3/b12-4-/t14-,15-,18-/m1/s1 |
| InChI Key | FCEVNJIUIMLVML-QPSVUOIXSA-N |
| Hazard Symbols | 6.1(b) |
| MSDS | msds/67159_1_480_81_9.pdf |
| Bioactivity | Seneciphylline is a toxic pyrrolizidine alkaloid in Senecio plants[1]. Seneciphylline significantly increases the activities of epoxide hydrase and glutathione-S-transferase but causes reduction of cytochrome P-450 and related monooxygenase activities[2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Signaling Pathways >> Metabolic Enzyme/Protease >> Gutathione S-transferase References [1]. Bandyopadhyay S, et al. Cytotoxicity of Senecio in macrophages is mediated via its induction of oxidative stress. Res Vet Sci. 2009 Aug;87(1):85-90. [2]. Kakrani HK, et al. Effect of seneciphylline and senecionine on hepatic drug metabolizing enzymes in rats. J Ethnopharmacol. 1984 Dec;12(3):271-8. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 577.7±50.0 °C at 760 mmHg Melting Point 217ºC Molecular Formula C18H23NO5 Molecular Weight 333.379 Flash Point 303.2±30.1 °C Exact Mass 333.157623 PSA 76.07000 LogP 0.81 Vapour Pressure 0.0±3.6 mmHg at 25°C Index of Refraction 1.581 InChIKey FCEVNJIUIMLVML-QPSVUOIXSA-N SMILES C=C1CC(=CC)C(=O)OC2CCN3CC=C(COC(=O)C1(C)O)C23 Storage condition 2-8℃ |
| Use of | Seneciphylline is a toxic pyrrolizidine alkaloid in Senecio plants[1]. Seneciphylline significantly increases the activities of epoxide hydrase and glutathione-S-transferase but causes reduction of cytochrome P-450 and related monooxygenase activities[2]. Properties Articles18 Name Seneciphylline Synonym More Synonyms Seneciphylline Biological Activity Description Seneciphylline is a toxic pyrrolizidine alkaloid in Senecio plants[1]. Seneciphylline significantly increases the activities of epoxide hydrase and glutathione-S-transferase but causes reduction of cytochrome P-450 and related monooxygenase activities[2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Signaling Pathways >> Metabolic Enzyme/Protease >> Gutathione S-transferase References [1]. Bandyopadhyay S, et al. Cytotoxicity of Senecio in macrophages is mediated via its induction of oxidative stress. Res Vet Sci. 2009 Aug;87(1):85-90. [2]. Kakrani HK, et al. Effect of seneciphylline and senecionine on hepatic drug metabolizing enzymes in rats. J Ethnopharmacol. 1984 Dec;12(3):271-8. Chemical & Physical Properties Molecular Formula C18H23NO5 Exact Mass 333.157623 PSA 76.07000 Index of Refraction 1.581 InChIKey FCEVNJIUIMLVML-QPSVUOIXSA-N Storage condition 2-8℃ |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Danger Regulations: 1544 International Maritime Transport Danger Regulations: 1544 International Air Transport Danger Regulations: 1544 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: ALKALOIDS, SOLID, N.O.S. (Seneciphylline) IMDG Code: ALKALOIDS, SOLID, N.O.S. (Seneciphylline) IMDG: Alkaloids, solid, n.o.s. (Seneciphylline) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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