CAS Number26585-13-7
Synonyms1-Vinyl-4-methoxy-β-carboline; dehydrocrenatine; HMS2271N07; TOB-10; Dehydrocrenation; 4-Methoxy-1-vinyl-9H-β-carboline
Molecular FormulaC14H12N2O
Molecular Weight224.258
Density1.3±0.1 g/cm3
Boiling Point461.2±40.0 °C at 760 mmHg
Appearanceyellow powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 26585-13-7 |
| Catalog No. | 2A-9066709 |
| Chinese Name | Dehydrocrenatine |
| Synonyms | 1-Vinyl-4-methoxy-β-carboline; dehydrocrenatine; HMS2271N07; TOB-10; Dehydrocrenation; 4-Methoxy-1-vinyl-9H-β-carboline |
| Molecular Formula | C14H12N2O |
| Molecular Weight | 224.258 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 461.2±40.0 °C at 760 mmHg |
| Appearance | yellow powder |
| Storage Condition | 2-8℃, dry, sealed |
| Application | Dehydroclenadine, a β-carbene alkaloid, is isolated from Ophiopogon japonicus. Dehydroclenadine induces apoptosis by activating ERK and JNK. Dehydroclenadine inhibits the invasion and migration of can |
| HTC | 2933990090 |
| SMILES | C=Cc1ncc(OC)c2c1[nH]c1ccccc12 |
| InChI | InChI=1S/C14H12N2O/c1-3-10-14-13(12(17-2)8-15-10)9-6-4-5-7-11(9)16-14/h3-8,16H,1H2,2H3 |
| InChI Key | HJVIUZHNRJYUTG-UHFFFAOYSA-N |
| Use of | Dehydrocrenatidine, a β-carboline alkaloid that can be isolated from Picrasma quassioides. Dehydrocrenatidine induces cell Apoptosis by activates ERK and JNK. Dehydrocrenatidine inhibits invasion and migration of cancer cells, it also suppresses neuronal excitability to exert analgesic effects[1][2]. Properties Name 1-ethenyl-4-methoxy-9H-pyrido[3,4-b]indole Synonym More Synonyms 1-Vinyl-4-methoxy-β-carboline Biological Activity Description Dehydrocrenatidine, a β-carboline alkaloid that can be isolated from Picrasma quassioides. Dehydrocrenatidine induces cell Apoptosis by activates ERK and JNK. Dehydrocrenatidine inhibits invasion and migration of cancer cells, it also suppresses neuronal excitability to exert analgesic effects[1][2]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Signaling Pathways >> MAPK/ERK Pathway >> ERK Research Areas >> Neurological Disease Signaling Pathways >> MAPK/ERK Pathway >> JNK Signaling Pathways >> Stem Cell/Wnt >> ERK References [1]. Ho HY, et al. Apoptotic effects of dehydrocrenatidine via JNK and ERK pathway regulation in oral squamous cell carcinoma. Biomed Pharmacother. 2021 May;137:111362. [2]. Hsieh MC, et al. Dehydrocrenatidine extracted from Picrasma quassioidesinduces the apoptosis of nasopharyngeal carcinoma cells through the JNK and ERK signaling pathways. Oncol Rep. 2021 Aug;46(2):166. Chemical & Physical Properties Molecular Formula C14H12N2O Exact Mass 224.094955 PSA 37.91000 Index of Refraction 1.737 InChIKey HJVIUZHNRJYUTG-UHFFFAOYSA-N Safety Information Hazard Codes Xi HS Code 2933990090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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