CAS Number56-06-4
Synonyms2,6-diaminopyrimidin-4(3H)-one; 2,6-Diaminopyrimidin-4-one; 2,4-Diamino-6-hydroxypyrimidine; 2,6-diaminopyrimidin-4-ol; 2,4-Diamino-6-hydroxy; 2,6-diamino-4-hydroxy-pyrimidine; 6-hydroxy-2,4-diaminopyrimidine; 2,6-Diamino-4(1H)-pyrimidinone; AURORA KA-376; MFCD00006098; 2,4-Diamino-6-pyrimidinone; 2,6-Diaminopyrimidin-4(1H)-one; EINECS 200-254-4; 2,4-diaminohypoxanthine; 6-Aminoisocytosine; 6-Hydroxy-2,4-pyrimidinediamine; DAHP; 2,4-DIAMINO-6-HYDROXY PYRIMIDINE
Molecular FormulaC4H6N4O
Molecular Weight126.12
Density1.6±0.1 g/cm3
Boiling Point524.0±53.0 °C at 760 mmHg
Melting Point285-286 °C (dec.)(lit.)
AppearanceSlightly white crystal
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 56-06-4 |
| Catalog No. | 2A-0202424 |
| Chinese Name | 2,4-二氨基-6-羟基嘧啶 |
| Synonyms | 2,6-diaminopyrimidin-4(3H)-one; 2,6-Diaminopyrimidin-4-one; 2,4-Diamino-6-hydroxypyrimidine; 2,6-diaminopyrimidin-4-ol; 2,4-Diamino-6-hydroxy; 2,6-diamino-4-hydroxy-pyrimidine; 6-hydroxy-2,4-diaminopyrimidine; 2,6-Diamino-4(1H)-pyrimidinone; AURORA KA-376; MFCD00006098; 2,4-Diamino-6-pyrimidinone; 2,6-Diaminopyrimidin-4(1H)-one; EINECS 200-254-4; 2,4-diaminohypoxanthine; 6-Aminoisocytosine; 6-Hydroxy-2,4-pyrimidinediamine; DAHP; 2,4-DIAMINO-6-HYDROXY PYRIMIDINE |
| Molecular Formula | C4H6N4O |
| Molecular Weight | 126.12 |
| Density | 1.6±0.1 g/cm3 |
| Boiling Point | 524.0±53.0 °C at 760 mmHg |
| Melting Point | 285-286 °C (dec.)(lit.) |
| Appearance | Slightly white crystal |
| Storage Condition | This product should be sealed and stored away from |
| Application | 2,4-Diamino-6-hydroxypyrimidine is a specific inhibitor of type I guanosine triphosphate cyclohydrolase I (GTP cyclohydrolase I; the rate-limiting enzyme in de novo protein synthesis), inhibiting BH4 |
| HTC | 29335995 |
| SMILES | NC1=CC(=O)N=C(N)N1 |
| InChI Key | InChIKey=SWELIMKTDYHAOY-UHFFFAOYSA-N |
| MSDS | msds/66309_1_56_06_4.pdf |
| Bioactivity | 2,4-Diamino-6-hydroxypyrimidine is a specific GTP cyclohydrolase I inhibitor (the rate-limiting enzyme in de novo pterin synthesis), blocks BH4 synthesis and suppresses NO production[1]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Target GTP cyclohydrolase I[1] References [1]. Sung YJ, et al. 2,4-Diamino-6-hydroxypyrimidine, an inhibitor of GTP cyclohydrolase I, suppresses nitric oxide production by chicken macrophages. Int J Immunopharmacol. 1994 Feb;16(2):101-8. Chemical & Physical Properties Density 1.6±0.1 g/cm3 Boiling Point 524.0±53.0 °C at 760 mmHg Melting Point 285-286 °C (dec.)(lit.) Molecular Formula C4H6N4O Molecular Weight 126.12 Flash Point 270.7±30.9 °C Exact Mass 126.054161 PSA 98.05000 LogP -1.29 Vapour Pressure 0.0±1.4 mmHg at 25°C Index of Refraction 1.770 Storage condition Desiccate at +4°C |
| Use of | 2,4-Diamino-6-hydroxypyrimidine is a specific GTP cyclohydrolase I inhibitor (the rate-limiting enzyme in de novo pterin synthesis), blocks BH4 synthesis and suppresses NO production[1]. Properties Articles26 Name 2,4-Diamino-6-hydroxypyrimidine Synonym More Synonyms 2,4-Diamino-6-hydroxypyrimidine Biological Activity Description 2,4-Diamino-6-hydroxypyrimidine is a specific GTP cyclohydrolase I inhibitor (the rate-limiting enzyme in de novo pterin synthesis), blocks BH4 synthesis and suppresses NO production[1]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology GTP cyclohydrolase I[1] References [1]. Sung YJ, et al. 2,4-Diamino-6-hydroxypyrimidine, an inhibitor of GTP cyclohydrolase I, suppresses nitric oxide production by chicken macrophages. Int J Immunopharmacol. 1994 Feb;16(2):101-8. Chemical & Physical Properties Molecular Formula C4H6N4O Exact Mass 126.054161 PSA 98.05000 LogP -1.29 Index of Refraction 1.770 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards 2,4-Diamino-6-hydroxypyrimidine Modification number: 6 Module 14. Shipping information UN number: not specified |
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