CAS Number65-71-4
Synonyms5-Methyl-2,4(1H,3H)-pyrimidinedione; Clospirazine; 5-methylpyrimidine-2,4-dione; 5-Methyluracil; THYMINE extrapure; Thymine; 4-Hydroxy-5-methylpyrimidin-2(1H)-one; 5-Methylpyrimidine-2,4-diol; ThyMine 5GR; 5-Methylpyrimidin-2,4(1H,3H)-dion; 2,4-dihydroxy-5-methylpyrimidine; D-THYMIDINE; THYMIN; EINECS 200-616-1; 5-Methylpyrimidine-2,4(1H,3H)-dione; MFCD00006026
Molecular FormulaC5H6N2O2
Molecular Weight126.11
Purity≥99%
Density1.4±0.1 g/cm3
Boiling Point403.8±37.0 °C at 760 mmHg
Melting Point~320 °C (dec.) (lit.)
Appearancepowder
EINECS200-616-1
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 65-71-4 |
| Catalog No. | 2A-9006611 |
| Chinese Name | 胸腺嘧啶 |
| Synonyms | 5-Methyl-2,4(1H,3H)-pyrimidinedione; Clospirazine; 5-methylpyrimidine-2,4-dione; 5-Methyluracil; THYMINE extrapure; Thymine; 4-Hydroxy-5-methylpyrimidin-2(1H)-one; 5-Methylpyrimidine-2,4-diol; ThyMine 5GR; 5-Methylpyrimidin-2,4(1H,3H)-dion; 2,4-dihydroxy-5-methylpyrimidine; D-THYMIDINE; THYMIN; EINECS 200-616-1; 5-Methylpyrimidine-2,4(1H,3H)-dione; MFCD00006026 |
| Molecular Formula | C5H6N2O2 |
| Molecular Weight | 126.11 |
| Purity | ≥99 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 403.8±37.0 °C at 760 mmHg |
| Melting Point | ~320 °C (dec.) (lit.) |
| Appearance | powder |
| Storage Condition | Sterile sealed packaging in brown glass bottles. S |
| Application | Thymine, one of the four bases of DNA, can serve as a target for 5-fluorouracil (5-FU) in cancer therapy, with a Km value of 2.3 μM. |
| EINECS | 200-616-1 |
| HTC | 2933599090 |
| UN(IATA) | UN 无资料 |
| PubChem ID | 24899883 |
| MDL Number | MFCD00006026 |
| SMILES | CC1=CNC(=O)NC1=O |
| InChI | 1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9) |
| InChI Key | RWQNBRDOKXIBIV-UHFFFAOYSA-N |
| Beilstein/REAXYS | 117880 |
| NACRES Code | NA.51 |
| UNSPSC | 41106305 |
| Hazard Symbols | Category 1 |
| MSDS | msds/6611_1_65_71_4.pdf |
| Bioactivity | Thymine is one of the four nucleobases in the nucleic acid of DNA and can be a target for actions of 5-fluorouracil (5-FU) in cancer treatment, with a Km of 2.3 μM. Related Catalog Natural Products >> Saccharides and Glycosides Research Areas >> Cancer Research Areas >> Metabolic Disease Target Human Endogenous Metabolite References [1]. Tuchman M, et al. Effects of uridine and thymidine on the degradation of 5-fluorouracil, uracil, and thymine by rat liver dihydropyrimidine dehydrogenase. Cancer Res. 1985 Nov;45(11 Pt 1):5553-6. Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 403.8±37.0 °C at 760 mmHg Melting Point 316 °C Molecular Formula C5H6N2O2 Molecular Weight 126.113 Flash Point 198.0±26.5 °C Exact Mass 126.042931 PSA 65.72000 LogP -2.09 Vapour Pressure 0.0±1.0 mmHg at 25°C Index of Refraction 1.614 InChIKey RWQNBRDOKXIBIV-UHFFFAOYSA-N SMILES Cc1c[nH]c(=O)[nH]c1=O Storage condition Store at RT. Stability Stable. Incompatible with strong oxidizing agents. |
| Use of | Thymine is one of the four nucleobases in the nucleic acid of DNA and can be a target for actions of 5-fluorouracil (5-FU) in cancer treatment, with a Km of 2.3 μM. Properties Articles106 Name Thymine Synonym More Synonyms Thymine Biological Activity Description Thymine is one of the four nucleobases in the nucleic acid of DNA and can be a target for actions of 5-fluorouracil (5-FU) in cancer treatment, with a Km of 2.3 μM. Related Catalog Natural Products >> Saccharides and Glycosides Research Areas >> Cancer Research Areas >> Metabolic Disease Human Endogenous Metabolite References [1]. Tuchman M, et al. Effects of uridine and thymidine on the degradation of 5-fluorouracil, uracil, and thymine by rat liver dihydropyrimidine dehydrogenase. Cancer Res. 1985 Nov;45(11 Pt 1):5553-6. Chemical & Physical Properties Molecular Formula C5H6N2O2 Exact Mass 126.042931 PSA 65.72000 LogP -2.09 Index of Refraction 1.614 InChIKey RWQNBRDOKXIBIV-UHFFFAOYSA-N Storage condition Store at RT. Stability Stable. Incompatible with strong oxidizing agents. |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Chemical name |
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