CAS Number29080-58-8
Synonyms2-(3,4-Dimethoxyphenyl)-5-hydroxy-7-methoxy-4H-chromen-4-one; 5-Hydroxy-3',4',7-trimethoxyflavone; luteolin-3'-4',7-trimethyl ether; 5-hydroxy-7,2',6'-trimethoxyflavone; 5-hydroxy-7,3',4'-trimethoxy-flavone; Luteolin-7,3',4'-trimethylether; 5-hydroxy-7,3',4'-trimethoxyflavone
Molecular FormulaC18H16O6
Molecular Weight328.316
Density1.3±0.1 g/cm3
Boiling Point536.3±50.0 °C at 760 mmHg
Appearanceyellow powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 29080-58-8 |
| Catalog No. | 2A-9066003 |
| Chinese Name | 5-羟基-7,3',4'-三甲氧基黄酮 |
| Synonyms | 2-(3,4-Dimethoxyphenyl)-5-hydroxy-7-methoxy-4H-chromen-4-one; 5-Hydroxy-3',4',7-trimethoxyflavone; luteolin-3'-4',7-trimethyl ether; 5-hydroxy-7,2',6'-trimethoxyflavone; 5-hydroxy-7,3',4'-trimethoxy-flavone; Luteolin-7,3',4'-trimethylether; 5-hydroxy-7,3',4'-trimethoxyflavone |
| Molecular Formula | C18H16O6 |
| Molecular Weight | 328.316 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 536.3±50.0 °C at 760 mmHg |
| Appearance | yellow powder |
| Storage Condition | 2-8℃, dry, sealed |
| Application | 7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone) is a flavonoid from the herbal family Verbenaceae (Lippia nodiflora L.), which has been shown to possess anti-inflammatory, antipyret |
| HTC | 2932999099 |
| SMILES | COc1cc(O)c2c(=O)cc(-c3ccc(OC)c(OC)c3)oc2c1 |
| InChI | InChI=1S/C18H16O6/c1-21-11-7-12(19)18-13(20)9-15(24-17(18)8-11)10-4-5-14(22-2)16(6-10)23-3/h4-9,19H,1-3H3 |
| InChI Key | HIXDQWDOVZUNNA-UHFFFAOYSA-N |
| Use of | 7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone) is a flavonoid from the herb Lippia nodiflora L. (Verbenaceae) which has been documented to exhibit anti-inflammatory, antipyretic, antitussive, antidiabetic, anticancer, and antimelanogenesis properties. 7,3',4'-Tri-O-methylluteolin obviously reduces the prodn of pro-inflammatory cytokines, such as TNF-α, IL-6, and IL-1β in a concentration-dependent manner. 7,3',4'-Tri-O-methylluteolin significantly induces reduction in the mRNA expressions of inducible nitric oxide synthase and cyclooxygenase-2, representing that inhibition occurs at the transcriptional level[1]. Properties Name 2-(3,4-dimethoxyphenyl)-5-hydroxy-7-methoxychromen-4-one Synonym More Synonyms 5-Hydroxy-3',4',7-trimethoxyflavone Biological Activity Description 7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone) is a flavonoid from the herb Lippia nodiflora L. (Verbenaceae) which has been documented to exhibit anti-inflammatory, antipyretic, antitussive, antidiabetic, anticancer, and antimelanogenesis properties. 7,3',4'-Tri-O-methylluteolin obviously reduces the prodn of pro-inflammatory cytokines, such as TNF-α, IL-6, and IL-1β in a concentration-dependent manner. 7,3',4'-Tri-O-methylluteolin significantly induces reduction in the mRNA expressions of inducible nitric oxide synthase and cyclooxygenase-2, representing that inhibition occurs at the transcriptional level[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> Interleukin Related Research Areas >> Inflammation/Immunology Signaling Pathways >> Apoptosis >> TNF Receptor Research Areas >> Metabolic Disease References Chemical & Physical Properties Molecular Formula C18H16O6 Exact Mass 328.094696 PSA 78.13000 Index of Refraction 1.606 InChIKey HIXDQWDOVZUNNA-UHFFFAOYSA-N Safety Information Hazard Codes Xi HS Code 2932999099 Synthetic Route 5,7,3',4... 5-Hydroxy-3'... 29080-58-8 Literature: AxoGlia Therapeutics S.A. Patent: EP2112145 A1, 2009 ; Location in patent: Page/Page column 16 ; Dimethyl sulfat... 5-Hydroxy-3'... 29080-58-8 Literature: Miles, Christopher O.; Main, Lyndsay Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1989 , p. 1623 - 1632 diazomethane 186581-53-3 32174-62-2 5-Hydroxy-3'... 29080-58-8 Literature: Matsuda, Hisashi; Morikawa, Toshio; Toguchida, Iwao; Yoshikawa, Masayuki Chemical and Pharmaceutical Bulletin, 2002 , vol. 50, # 6 p. 788 - 795 Precursor & DownStream Precursor 9 CAS#:855-97-0 5,7,3',4'-Tetra... CAS#:520-34-3 CAS#:77-78-1 Dimethyl sulfate CAS#:186581-53-3 diazomethane DownStream 10 CAS#:855-97-0 5,7,3',4'-Tetra... CAS#:117-39-5 CAS#:2174-64-3 CAS#:93-07-2 Veratric acid |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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