CAS Number2457-80-9
Synonyms5-Methylthioadenosine; 1-(6-amino-9H-purin-9-yl)-1-deoxy-5-S-methyl-5-thio-β-D-Ribofuranose; Vitamin L2; 5'-S-Methylthioadenosine; (2R,3R,4S,5S)-2-(6-aminopurin-9-yl)-5-(methylsulfanylmethyl)oxolane-3,4-diol; 5'-S-Methyl-5'-thioadenosine; 7-[Tetrahydro-3,4-dihydroxy-5-(methylmeracptomrthyl)-2-futyl]adenine; 5'-Deoxy-5'-(methylthio)adenosine; MFCD00010533; MTA,Methylthioadenosine; 5'-Deoxy-5'-Methylthioadenosine; Adenylthiomethylpentose; (2R,3R,4S,5S)-2-(6-Amino-9H-purin-9-yl)-5-((methylthio)methyl)tetrahydrofuran-3,4-diol
Molecular FormulaC11H15N5O3S
Molecular Weight297.33
Purity≥98 (HPLC)%
Density1.9±0.1 g/cm3
Boiling Point642.7±65.0 °C at 760 mmHg
Melting Point210-213ºC (dec.)
Appearancepowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 2457-80-9 |
| Catalog No. | 2A-9065792 |
| Chinese Name | 5′-脱氧-5′-(甲硫基)腺苷 |
| Synonyms | 5-Methylthioadenosine; 1-(6-amino-9H-purin-9-yl)-1-deoxy-5-S-methyl-5-thio-β-D-Ribofuranose; Vitamin L2; 5'-S-Methylthioadenosine; (2R,3R,4S,5S)-2-(6-aminopurin-9-yl)-5-(methylsulfanylmethyl)oxolane-3,4-diol; 5'-S-Methyl-5'-thioadenosine; 7-[Tetrahydro-3,4-dihydroxy-5-(methylmeracptomrthyl)-2-futyl]adenine; 5'-Deoxy-5'-(methylthio)adenosine; MFCD00010533; MTA,Methylthioadenosine; 5'-Deoxy-5'-Methylthioadenosine; Adenylthiomethylpentose; (2R,3R,4S,5S)-2-(6-Amino-9H-purin-9-yl)-5-((methylthio)methyl)tetrahydrofuran-3,4-diol |
| Molecular Formula | C11H15N5O3S |
| Molecular Weight | 297.33 |
| Purity | ≥98 (HPLC) |
| Density | 1.9±0.1 g/cm3 |
| Boiling Point | 642.7±65.0 °C at 760 mmHg |
| Melting Point | 210-213ºC (dec.) |
| Appearance | powder |
| Storage Condition | -20 ℃ storage |
| Application | 5'-Methylthioadenosine is produced from S-adenosine and has a potent inhibitory effect. |
| HTC | 2934999090 |
| PubChem ID | 24893915 |
| MDL Number | MFCD00010533 |
| SMILES | CSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23 |
| InChI | 1S/C11H15N5O3S/c1-20-2-5-7(17)8(18)11(19-5)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14)/t5-,7-,8-,11-/m1/s1 |
| InChI Key | WUUGFSXJNOTRMR-IOSLPCCCSA-N |
| Beilstein/REAXYS | 42420 |
| NACRES Code | NA.51 |
| UNSPSC | 41106305 |
| MSDS | msds/65792_1_2457_80_9.pdf |
| Use of | 5'-Methylthioadenosine is produced from S-adenosylmethionine and behaves as a powful inhibitory product. Properties Articles62 Name 5'-S-methyl-5'-thioadenosine Synonym More Synonyms Adenylthiomethylpentose Biological Activity Description 5'-Methylthioadenosine is produced from S-adenosylmethionine and behaves as a powful inhibitory product. Related Catalog Research Areas >> Metabolic Disease Natural Products >> Others Human Endogenous Metabolite In Vitro 5'-Methylthioadenosine (MTA) can affect cellular processes in many ways. 5'-Methylthioadenosine has been shown to influence numerous critical responses of the cell including regulation of gene expression, proliferation, differentiation and apoptosis. Although most of these responses have been observed at the pharmacological level, their specificity makes it tempting to speculate that endogenous 5'-Methylthioadenosine could play a regulatory role in the cell. Finally, observations carried out in models of liver damage and cancer demonstrate a therapeutic potential for 5'-Methylthioadenosine that deserves further consideration[1]. References [1]. Avila MA, et al. Methylthioadenosine. Int J Biochem Cell Biol. 2004 Nov;36(11):2125-30. Chemical & Physical Properties Molecular Formula C11H15N5O3S Exact Mass 297.089569 PSA 144.61000 Index of Refraction 1.843 InChIKey WUUGFSXJNOTRMR-IOSLPCCCSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Adenosine, 5'-S-methyl-5'-thio- CAS REGISTRY NUMBER : BEILSTEIN REFERENCE NO. : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C11-H15-N5-O3-S MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value MUTATION DATA TYPE OF TEST : DNA inhibition TEST SYSTEM : Rodent - rat Liver DOSE/DURATION : 100 umol/L REFERENCE : CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 8,653,1987 Safety Information Signal Word Warning Hazard Statements H302 Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter Hazard Codes Xi RIDADR NONH for all modes of transport WGK Germany 3 RTECS AU7410000 HS Code 2934999090 Precursor & DownStream Precursor 10 CAS#:74-93-1 Methyl mercaptan CAS#:892-48-8 5'-Chloro-5'-de... CAS#:63-68-3 L-Methionine CAS#:56-65-5 Adenosine triph... DownStream 4 CAS#:4754-39-6 5'-Deoxyadenosine CAS#:23656-67-9 (2R,3S,4S)-2,3,... CAS#:73-24-5 CAS#:118560-47-7 5'-deoxy-5'-((m... |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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