CAS Number51322-75-9
Synonyms5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine; 5-chloro-N-(imidazolidin-2-ylidene)-2,1,3-benzothiadiazol-4-amine; Sirdalud; Ternelin; Tizanidina [INN-Spanish]; Zanaflex(R); Tizanidina; MFCD00798231; Tizanidinum; Zanaflex; 5-chloro-4-(2-imidazolin-2-ylamino)-2,1,3-benzothiadiazole; Tizanidinum [INN-Latin]
Molecular FormulaC9H8N5Cl1S1
Molecular Weight253.71
Purity98%
Density1.82 g/cm3
Boiling Point391.2ºC at 760 mmHg
Melting Point221 - 223ºC
Appearancewhite solid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 51322-75-9 |
| Catalog No. | 2A-9006481 |
| Chinese Name | 替扎尼定 |
| Synonyms | 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine; 5-chloro-N-(imidazolidin-2-ylidene)-2,1,3-benzothiadiazol-4-amine; Sirdalud; Ternelin; Tizanidina [INN-Spanish]; Zanaflex(R); Tizanidina; MFCD00798231; Tizanidinum; Zanaflex; 5-chloro-4-(2-imidazolin-2-ylamino)-2,1,3-benzothiadiazole; Tizanidinum [INN-Latin] |
| Molecular Formula | C9H8N5Cl1S1 |
| Molecular Weight | 253.71 |
| Purity | 98 |
| Density | 1.82 g/cm3 |
| Boiling Point | 391.2ºC at 760 mmHg |
| Melting Point | 221 - 223ºC |
| Appearance | white solid |
| Water Solubility | H2O: ~29 mg/mL |
| Storage Condition | -20℃ |
| Application | Tizanidine is an α2-adrenergic receptor agonist that inhibits the release of neurotransmitters from CNS norepinephrine-activated neurons. |
| HTC | 2934999090 |
| MDL Number | MFCD00865192 |
| SMILES | Clc1ccc2nsnc2c1NC1=NCCN1 |
| InChI | InChI=1S/C9H8ClN5S/c10-5-1-2-6-8(15-16-14-6)7(5)13-9-11-3-4-12-9/h1-2H,3-4H2,(H2,11,12,13) |
| InChI Key | XFYDIVBRZNQMJC-UHFFFAOYSA-N |
| MSDS | msds/6481_1_51322_75_9.pdf |
| Use of | Properties Name tizanidine Synonym More Synonyms Tizanidine Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Neurological Disease References [1]. Kamen L, et al. A practical overview of tizanidine use for spasticity secondary to multiple sclerosis, stroke, and spinal cord injury. Curr Med Res Opin. 2008 Feb;24(2):425-39. Chemical & Physical Properties Exact Mass 253.01900 PSA 90.44000 LogP 1.55320 InChIKey XFYDIVBRZNQMJC-UHFFFAOYSA-N Storage condition -20℃ Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : 2,1,3-Benzothiadiazole, 5-chloro-4-(2-imidazolin-2-ylamino)- CAS REGISTRY NUMBER : 51322-75-9 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C9-H8-Cl-N5-S MOLECULAR WEIGHT : WISWESSER LINE NOTATION : T56 BNSNJ FM- BT5M CN BUTJ& GG HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Skin and Appendages - hair REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 30,793,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Behavioral - changes in motor activity (specific assay) Behavioral - ataxia Skin and Appendages - hair REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 30,793,1980 Safety Information Hazard Codes Xn: Harmful; Risk Phrases R22 Safety Phrases 26-36 WGK Germany 3 RTECS DK9910000 HS Code 2934999090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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