CAS Number87691-27-8
Synonyms(4S)-4-Hydroxy-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-proline; MFCD02094406; Boc-(2S,4S)-(-)-4-hydroxypyrrolidine-2-carboxylic acid; (4R)-4-Hydroxy-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-proline
Molecular FormulaC10H17NO5
Molecular Weight231.25
Purity97%
Density1.3±0.1 g/cm3
Boiling Point390.9±42.0 °C at 760 mmHg
Melting Point146 °C (D) (lit.)
Appearancesolid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 87691-27-8 |
| Catalog No. | 2A-9064706 |
| Chinese Name | N-Boc-顺式-4-羟基-L-脯氨酸 |
| Synonyms | (4S)-4-Hydroxy-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-proline; MFCD02094406; Boc-(2S,4S)-(-)-4-hydroxypyrrolidine-2-carboxylic acid; (4R)-4-Hydroxy-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-proline |
| Molecular Formula | C10H17NO5 |
| Molecular Weight | 231.25 |
| Purity | 97 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 390.9±42.0 °C at 760 mmHg |
| Melting Point | 146 °C (D) (lit.) |
| Appearance | solid |
| Storage Condition | In a dry, cool, sealed place, in an inert gas envi |
| Application | N-Boc-cis-4-hydroxy-L-proline is a non-cleavable ADC linker used in the synthesis of antibody drug conjugates (ADC). N-Boc-cis-4-hydroxy-L-proline is also an alkyl chain-based PROTAC linker and can be |
| HTC | 2933990090 |
| PubChem ID | 24884008 |
| MDL Number | MFCD02094406 |
| SMILES | CC(C)(C)OC(=O)N1C[C@@H](O)C[C@H]1C(O)=O |
| InChI | 1S/C10H17NO5/c1-10(2,3)16-9(15)11-5-6(12)4-7(11)8(13)14/h6-7,12H,4-5H2,1-3H3,(H,13,14)/t6-,7-/m0/s1 |
| InChI Key | BENKAPCDIOILGV-BQBZGAKWSA-N |
| NACRES Code | NA.22 |
| eCl@ss | 32160406 |
| UNSPSC | 12352209 |
| MSDS | msds/64706_1_87691_27_8.pdf |
| Bioactivity | N-Boc-cis-4-hydroxy-L-proline is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-hydroxy-L-proline is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2 Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker Target Non-cleavable In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. References [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 390.9±42.0 °C at 760 mmHg Melting Point 146ºC Molecular Formula C10H17NO5 Molecular Weight 231.246 Flash Point 190.2±27.9 °C Exact Mass 231.110672 PSA 87.07000 LogP -0.71 Vapour Pressure 0.0±2.0 mmHg at 25°C Index of Refraction 1.531 InChIKey BENKAPCDIOILGV-BQBZGAKWSA-N SMILES CC(C)(C)OC(=O)N1CC(O)CC1C(=O)O |
| Use of | N-Boc-cis-4-hydroxy-L-proline is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-hydroxy-L-proline is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2 Properties Name N-BOC-cis-4-Hydroxy-L-proline Synonym More Synonyms N-BOC-cis-4-Hydroxy-L-proline Biological Activity Description N-Boc-cis-4-hydroxy-L-proline is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-hydroxy-L-proline is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2 Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker Non-cleavable In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. References [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. Chemical & Physical Properties Molecular Formula C10H17NO5 Exact Mass 231.110672 PSA 87.07000 LogP -0.71 Index of Refraction 1.531 InChIKey BENKAPCDIOILGV-BQBZGAKWSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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