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Atorvastatin

Name: Atorvastatin
Brand: 2A Biotech
SKU: 2A-9064577

CAS Number110862-48-1

SynonymsUNII:36TN91XZ0V; 1h-pyrrole-1-heptanoic acid

Molecular FormulaC33H35FN2O5

Molecular Weight558.65

Purity98%

Density1.2±0.1 g/cm3

Boiling Point722.2±60.0 °C at 760 mmHg

MSDSChinese English

Cat. No.: 2A-9064577 Purity: 98%

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Quality Control of [ 110862-48-1 ] Purity: 98% SDS Specification MoL

Chemical & Physical Properties
CAS Number	110862-48-1
Catalog No.	2A-9064577
Chinese Name	阿伐他汀
Synonyms	UNII:36TN91XZ0V; 1h-pyrrole-1-heptanoic acid
Molecular Formula	C33H35FN2O5
Molecular Weight	558.65
Purity	98
Density	1.2±0.1 g/cm3
Boiling Point	722.2±60.0 °C at 760 mmHg
Storage Condition	room temperature, dry
Application	(rel)-Atorvastatin is a relative configuration of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor with the ability to effectively lower blood lipids. Atorvastatin inhibits t
HTC	2942000000
MDL Number	C33H35FN2O5
SMILES	CC(C)c1c(C(=O)Nc2ccccc2)c(-c2ccccc2)c(-c2ccc(F)cc2)n1CCC(O)CC(O)CC(=O)O
InChI	InChI=1S/2C33H35FN2O5.Ca/c21-21(2)31-30(33(41)35-25-11-7-4-8-12-25)29(22-9-5-3-6-10-22)32(23-13-15-24(34)16-14-23)36(31)18-17-26(37)19-27(38)20-28(39)40;/h23-16,21,26-27,37-38H,17-20H2,1-2H3,(H,35,41)(H,39,40);/q;;+2/p-2/t2*26-,27-;/m11./s1
InChI Key	XUKUURHRXDUEBC-UHFFFAOYSA-N
MSDS	msds/64577_1_110862_48_1.pdf
Bioactivity	(rel)-Atorvastatin, a relative configuration of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively[1][2][3]. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> HMG-CoA Reductase (HMGCR) Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease References [1]. Santodomingo-Garzón T, et al. Atorvastatin inhibits inflammatory hypernociception. Br J Pharmacol. 2006 Sep;149(1):14-22. [2]. Turner NA, et al. Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J Cardiovasc Pharmacol. 2007 Oct;50(4):458-61. [3]. Nawrocki, J.W., et al., Reduction of LDL cholesterol by 25% to 60% in patients with primary hypercholesterolemia by atorvastatin, a new HMG-CoA reductase inhibitor. Arterioscler Thromb Vasc Biol, 1995. 15(5): p. 678-82. [4]. Ming-Bai Hu, et al. Atorvastatin induces autophagy in MDA-MB-231 breast cancer cells. Ultrastruct Pathol. Sep-Oct 2018;42(5):409-415. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 722.2±60.0 °C at 760 mmHg Molecular Formula C33H35FN2O5 Molecular Weight 558.640 Flash Point 390.6±32.9 °C Exact Mass 558.252991 PSA 111.79000 LogP 4.13 Vapour Pressure 0.0±2.5 mmHg at 25°C Index of Refraction 1.603 InChIKey XUKUURHRXDUEBC-UHFFFAOYSA-N SMILES CC(C)c1c(C(=O)Nc2ccccc2)c(-c2ccccc2)c(-c2ccc(F)cc2)n1CCC(O)CC(O)CC(=O)O
Use of	(rel)-Atorvastatin, a relative configuration of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively[1][2][3]. Properties Name Atorvastatin Synonym More Synonyms (rel)-Atorvastatin Biological Activity Description (rel)-Atorvastatin, a relative configuration of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively[1][2][3]. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> HMG-CoA Reductase (HMGCR) Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease References [1]. Santodomingo-Garzón T, et al. Atorvastatin inhibits inflammatory hypernociception. Br J Pharmacol. 2006 Sep;149(1):14-22. [2]. Turner NA, et al. Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J Cardiovasc Pharmacol. 2007 Oct;50(4):458-61. [3]. Nawrocki, J.W., et al., Reduction of LDL cholesterol by 25% to 60% in patients with primary hypercholesterolemia by atorvastatin, a new HMG-CoA reductase inhibitor. Arterioscler Thromb Vasc Biol, 1995. 15(5): p. 678-82. [4]. Ming-Bai Hu, et al. Atorvastatin induces autophagy in MDA-MB-231 breast cancer cells. Ultrastruct Pathol. Sep-Oct 2018;42(5):409-415. Chemical & Physical Properties Molecular Formula C33H35FN2O5 Exact Mass 558.252991 PSA 111.79000 Index of Refraction 1.603 InChIKey XUKUURHRXDUEBC-UHFFFAOYSA-N
Transport Info	Product name: Atorvastatin

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Atorvastatin

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