![3-Thiopheneacetic acid, 5-[bis(carboxymethyl)amino]-2-carboxy-4-cyano-, strontium salt (1:2) structure, CAS 135459-87-9](/structures/80000/64525_1_135459_87_9.png)
CAS Number135459-87-9
Synonyms5-[Bis(carboxymethyl)amino]-3-(carboxymethyl)-4-cyano-2-thiophenecarboxylic acid; 5-[Bis(carboxymethyl)amino]-3-(carboxymethyl)-4-cyanothiophene-2-carboxylic acid; Strontium Ranelate; Ranelic Acid Strontium Salt
Molecular FormulaC12H6N2O8SSr2
Molecular Weight513.49
Purity≥98 (HPLC)%
Density1.8±0.1 g/cm3
Boiling Point778.8±60.0 °C at 760 mmHg
Melting Point>310°C (dec.)
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 135459-87-9 |
| Catalog No. | 2A-9064525 |
| Chinese Name | 雷尼酸锶 |
| Synonyms | 5-[Bis(carboxymethyl)amino]-3-(carboxymethyl)-4-cyano-2-thiophenecarboxylic acid; 5-[Bis(carboxymethyl)amino]-3-(carboxymethyl)-4-cyanothiophene-2-carboxylic acid; Strontium Ranelate; Ranelic Acid Strontium Salt |
| Molecular Formula | C12H6N2O8SSr2 |
| Molecular Weight | 513.49 |
| Purity | ≥98 (HPLC) |
| Density | 1.8±0.1 g/cm3 |
| Boiling Point | 778.8±60.0 °C at 760 mmHg |
| Melting Point | >310°C (dec.) |
| Appearance | powder |
| Water Solubility | H2O: soluble1mg/mL, clear (warmed) |
| Storage Condition | -20°C Freezer |
| Application | Strontium ranelate (S12911) can stimulate calcium-sensitive receptors (CaSR) and promote the differentiation of preosteoblasts into osteoblasts. |
| HTC | 2942000000 |
| SMILES | [Sr+2].[Sr+2].[s]1c(c(c(c1C(=O)[O-])CC(=O)[O-])C#N)N(CC(=O)[O-])CC(=O)[O-] |
| InChI | 1S/C12H10N2O8S.2Sr/c13-2-6-5(1-7(15)16)10(12(21)22)23-11(6)14(3-8(17)18)4-9(19)20;;/h1,3-4H2,(H,15,16)(H,17,18)(H,19,20)(H,21,22);;/q;2*+2/p-4 |
| InChI Key | XXUZFRDUEGQHOV-UHFFFAOYSA-J |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | transportation |
| MSDS | msds/64525_1_135459_87_9.pdf |
| Bioactivity | Strontium ranelate(S12911) stimulates the calcium sensing receptors (CaSR) and leads to the differentiation of pre-osteoblast to osteoblast which increases the bone formation.IC50 value:Target: CaSRStrontium Ranelate is a bone metabolism modulator that inhibits bone resorption while maintaining bone formation. Strontium Ranelate acts by increasing bone formation and decreasing bone resorption, thus rebalancing bone turnover in favour of bone formation, an effect that results in increased bone mass and strength. Commonly used as an antiosteoporotic. Strontium Ranelate has shown efficacy in preventing early postmenopausal bone loss and reducing the risk of hip fracture in women with postmenopausal osteoporosis. Related Catalog Signaling Pathways >> GPCR/G Protein >> CaSR Research Areas >> Metabolic Disease References [1]. Bonnelye E, Chabadel A, Saltel F, Jurdic P. Dual effect of strontium ranelate: stimulation of osteoblast differentiation and inhibition of osteoclast formation and resorption in vitro. Bone. 2008 Jan;42(1):129-38. Epub 2007 Sep 12. [2]. Marie PJ. Strontium ranelate: a dual mode of action rebalancing bone turnover in favour of bone formation. Curr Opin Rheumatol. 2006 Jun;18 Suppl 1:S11-5. [3]. P. J. Marie .Strontium ranelate: a novel mode of action optimizing bone formation and resorption. Osteoporosis International. 2005,16(1): S7-S10 [4]. Sorbera, L.A., Castaner, et al . Strontium Ranelate .Drugs Fut 2003, 28(4): 328 [5]. J Buehler, P Chappuis, J.L Saffar, et al. Strontium ranelate inhibits bone resorption while maintaining bone formation in alveolar bone in monkeys (Macaca fascicularis). Bone. 2001,29(2): 176-179. Chemical & Physical Properties Density 1.8±0.1 g/cm3 Boiling Point 778.8±60.0 °C at 760 mmHg Melting Point >310°C (dec.) Molecular Formula C12H6N2O8SSr2 Molecular Weight 513.49 Flash Point 424.8±32.9 °C PSA 160.47000 LogP -0.90 Vapour Pressure 0.0±2.8 mmHg at 25°C Index of Refraction 1.695 InChIKey XXUZFRDUEGQHOV-UHFFFAOYSA-J SMILES N#Cc1c(N(CC(=O)[O-])CC(=O)[O-])sc(C(=O)[O-])c1CC(=O)[O-].[Sr+2].[Sr+2] Storage condition -20°C Freezer Water Solubility H2O: soluble1mg/mL, clear (warmed) |
| Use of | Strontium ranelate(S12911) stimulates the calcium sensing receptors (CaSR) and leads to the differentiation of pre-osteoblast to osteoblast which increases the bone formation.IC50 value:Target: CaSRStrontium Ranelate is a bone metabolism modulator that inhibits bone resorption while maintaining bone formation. Strontium Ranelate acts by increasing bone formation and decreasing bone resorption, thus rebalancing bone turnover in favour of bone formation, an effect that results in increased bone mass and strength. Commonly used as an antiosteoporotic. Strontium Ranelate has shown efficacy in preventing early postmenopausal bone loss and reducing the risk of hip fracture in women with postmenopausal osteoporosis. Properties Name 2,2'-((5-Carboxy-4-(carboxymethyl)-3-cyanothiophen-2-yl)azanediyl)diacetic acid, distrontium salt Synonym More Synonyms Strontium Ranelate Biological Activity Description Strontium ranelate(S12911) stimulates the calcium sensing receptors (CaSR) and leads to the differentiation of pre-osteoblast to osteoblast which increases the bone formation.IC50 value:Target: CaSRStrontium Ranelate is a bone metabolism modulator that inhibits bone resorption while maintaining bone formation. Strontium Ranelate acts by increasing bone formation and decreasing bone resorption, thus rebalancing bone turnover in favour of bone formation, an effect that results in increased bone mass and strength. Commonly used as an antiosteoporotic. Strontium Ranelate has shown efficacy in preventing early postmenopausal bone loss and reducing the risk of hip fracture in women with postmenopausal osteoporosis. Related Catalog Signaling Pathways >> GPCR/G Protein >> CaSR Research Areas >> Metabolic Disease References [1]. Bonnelye E, Chabadel A, Saltel F, Jurdic P. Dual effect of strontium ranelate: stimulation of osteoblast differentiation and inhibition of osteoclast formation and resorption in vitro. Bone. 2008 Jan;42(1):129-38. Epub 2007 Sep 12. [2]. Marie PJ. Strontium ranelate: a dual mode of action rebalancing bone turnover in favour of bone formation. Curr Opin Rheumatol. 2006 Jun;18 Suppl 1:S11-5. [3]. P. J. Marie .Strontium ranelate: a novel mode of action optimizing bone formation and resorption. Osteoporosis International. 2005,16(1): S7-S10 [4]. Sorbera, L.A., Castaner, et al . Strontium Ranelate .Drugs Fut 2003, 28(4): 328 [5]. J Buehler, P Chappuis, J.L Saffar, et al. Strontium ranelate inhibits bone resorption while maintaining bone formation in alveolar bone in monkeys (Macaca fascicularis). Bone. 2001,29(2): 176-179. Chemical & Physical Properties Molecular Formula C12H6N2O8SSr2 PSA 160.47000 LogP -0.90 Index of Refraction 1.695 InChIKey XXUZFRDUEGQHOV-UHFFFAOYSA-J |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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