CAS Number152-53-4
Synonyms1-(4-chloro-phenyl)-6,6-dimethyl-1,6-dihydro-[1,3,5]triazine-2,4-diyldiamine,hydrochloride; 4,6-diamino-1-(4'-chlorophenyl)-1,2-dihydro-2,2-dimethyl-1,3,5-triazine; CYCLOGUANIL HYDROCHLORIDE; BN 2410; Chloroguanide triazine hydrochloride; 1-(4-chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine hydrochloride; 1-(4-CHLOROPHENYL)-4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-1,3,5-TRIAZINE HCL; 1-(4-Chlorophenyl)-1,6-dihydro-6,6-dimethyl-1,3,5-triazine-2,4-diamine monohydrochloride; 1-(4'-chlorophenyl)-2,2-dimethyl-4,6-diamino-1,2-dihydro-1,3,5-triazine hydrochloride; 1-(4-Chlor-phenyl)-6,6-dimethyl-1,6-dihydro-[1,3,5]triazin-2,4-diyldiamin,Hydrochlorid
Molecular FormulaC11H15Cl2N5
Molecular Weight288.182
Boiling Point400.7ºC at 760mmHg
Melting Point210-215ºC
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 152-53-4 |
| Catalog No. | 2A-9063401 |
| Chinese Name | 环氯胍 |
| Synonyms | 1-(4-chloro-phenyl)-6,6-dimethyl-1,6-dihydro-[1,3,5]triazine-2,4-diyldiamine,hydrochloride; 4,6-diamino-1-(4'-chlorophenyl)-1,2-dihydro-2,2-dimethyl-1,3,5-triazine; CYCLOGUANIL HYDROCHLORIDE; BN 2410; Chloroguanide triazine hydrochloride; 1-(4-chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine hydrochloride; 1-(4-CHLOROPHENYL)-4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-1,3,5-TRIAZINE HCL; 1-(4-Chlorophenyl)-1,6-dihydro-6,6-dimethyl-1,3,5-triazine-2,4-diamine monohydrochloride; 1-(4'-chlorophenyl)-2,2-dimethyl-4,6-diamino-1,2-dihydro-1,3,5-triazine hydrochloride; 1-(4-Chlor-phenyl)-6,6-dimethyl-1,6-dihydro-[1,3,5]triazin-2,4-diyldiamin,Hydrochlorid |
| Molecular Formula | C11H15Cl2N5 |
| Molecular Weight | 288.182 |
| Boiling Point | 400.7ºC at 760mmHg |
| Melting Point | 210-215ºC |
| Storage Condition | room temperature, dry |
| Application | Cycloguanil hydrochloride is the active metabolite of Proguanil and acts on malarial schizonts in red blood cells and hepatocytes. |
| MDL Number | MFCD00035308 |
| SMILES | CC1(C)N=C(N)N=C(N)N1c1ccc(Cl)cc1.Cl |
| InChI | InChI=1S/C11H14ClN5.ClH/c1-11(2)16-9(13)15-10(14)17(11)8-5-3-7(12)4-6-8;/h3-6H,1-2H3,(H4,13,14,15,16);1H |
| InChI Key | MOUAPRKJJUXEIE-UHFFFAOYSA-N |
| Hazard Symbols | transportation |
| MSDS | msds/63401_1_152_53_4.pdf |
| Bioactivity | Cycloguanil hydrochloride, the active metabolite of Proguanil, acts on malaria schizonts in erythrocytes and hepatocytes[1]. Related Catalog Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Infection References [1]. Matthaei J, et al. OCT1 Deficiency Affects Hepatocellular Concentrations and Pharmacokinetics of Cycloguanil, the Active Metabolite of the Antimalarial Drug Proguanil. Clin Pharmacol Ther. 2019 Jan;105(1):190-200. Chemical & Physical Properties Boiling Point 400.7ºC at 760mmHg Melting Point 210-215ºC Molecular Formula C11H15Cl2N5 Molecular Weight 288.17600 Flash Point 196.1ºC Exact Mass 287.07000 PSA 80.00000 LogP 2.66430 Vapour Pressure 1.25E-06mmHg at 25°C InChIKey MOUAPRKJJUXEIE-UHFFFAOYSA-N SMILES CC1(C)N=C(N)N=C(N)N1c1ccc(Cl)cc1.Cl |
| Use of | Cycloguanil hydrochloride, the active metabolite of Proguanil, acts on malaria schizonts in erythrocytes and hepatocytes[1]. Properties Name 1-(4-chlorophenyl)-6,6-dimethyl-1,3,5-triazine-2,4-diamine,hydrochloride Synonym More Synonyms Cycloguanil Hydrochloride Biological Activity Description Cycloguanil hydrochloride, the active metabolite of Proguanil, acts on malaria schizonts in erythrocytes and hepatocytes[1]. Related Catalog Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Infection References [1]. Matthaei J, et al. OCT1 Deficiency Affects Hepatocellular Concentrations and Pharmacokinetics of Cycloguanil, the Active Metabolite of the Antimalarial Drug Proguanil. Clin Pharmacol Ther. 2019 Jan;105(1):190-200. Chemical & Physical Properties Exact Mass 287.07000 PSA 80.00000 LogP 2.66430 InChIKey MOUAPRKJJUXEIE-UHFFFAOYSA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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