CAS Number90417-38-2
Synonyms8-Hydroxy-2-methylquinazolin-4(1H)-one; 2-methylquinazoline-4,8-diol; MFCD00942555; 8-hydroxy-2-methyl-1H-quinazolin-4-one; 8-hydroxy-2-methylquinazolin-4(3H)-one; 8-Hydroxy-2-methyl-4(1H)-quinazolinone; 8-Hydroxy-2-methyl-4(3H)-quinazolinone
Molecular FormulaC9H8N2O2
Molecular Weight176.17
Purity≥98 (HPLC)%
Density1.4±0.1 g/cm3
Boiling Point345.4±44.0 °C at 760 mmHg
Melting Point253-258ºC
Appearancesolid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 90417-38-2 |
| Catalog No. | 2A-9062904 |
| Chinese Name | 2-甲基-8-羟基-4-喹唑啉酮 |
| Synonyms | 8-Hydroxy-2-methylquinazolin-4(1H)-one; 2-methylquinazoline-4,8-diol; MFCD00942555; 8-hydroxy-2-methyl-1H-quinazolin-4-one; 8-hydroxy-2-methylquinazolin-4(3H)-one; 8-Hydroxy-2-methyl-4(1H)-quinazolinone; 8-Hydroxy-2-methyl-4(3H)-quinazolinone |
| Molecular Formula | C9H8N2O2 |
| Molecular Weight | 176.17 |
| Purity | ≥98 (HPLC) |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 345.4±44.0 °C at 760 mmHg |
| Melting Point | 253-258ºC |
| Appearance | solid |
| Water Solubility | DMSO: 35 mg/mL, soluble |
| Storage Condition | Sealed in a cool, dry environment at -20 ºC |
| Application | NU1025 is a potent PARP inhibitor with an IC50 of 400 nM and a Ki of 48 nM. NU1025 can enhance the cytotoxicity of ionizing radiation and anticancer drugs, and has anticancer and neuroprotective effec |
| HTC | 2933990090 |
| MDL Number | MFCD00942555 |
| SMILES | [nH]1[c](c2c(nc1C)c(ccc2)O)=O |
| InChI | 1S/C9H8N2O2/c1-5-10-8-6(9(13)11-5)3-2-4-7(8)12/h2-4,12H,1H3,(H,10,11,13) |
| InChI Key | YJDAOHJWLUNFLX-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/62904_1_90417_38_2.pdf |
| Use of | NU1025 is a potent PARP inhibitor with an IC50 of 400 nM and a Ki of 48 nM. NU1025 potentiates the cytotoxicity of ionizing radiation and anticancer drugs. NU1025 has anti-cancer and neuroprotective activity[1][2][3]. Properties Name nu 1025 Synonym More Synonyms NU1025 Biological Activity Description NU1025 is a potent PARP inhibitor with an IC50 of 400 nM and a Ki of 48 nM. NU1025 potentiates the cytotoxicity of ionizing radiation and anticancer drugs. NU1025 has anti-cancer and neuroprotective activity[1][2][3]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Epigenetics >> PARP Research Areas >> Neurological Disease Signaling Pathways >> Cell Cycle/DNA Damage >> PARP IC50: 400 nM (PARP)[2] Ki: 48 nM (PARP)[3] References [1]. Kaundal RK, et al. Neuroprotective effects of NU1025, a PARP inhibitor in cerebral ischemia are mediated through reduction in NAD depletion and DNA fragmentation. Life Sci. 2006 Nov 10;79(24):2293-302. [2]. Bowman KJ, et al. Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU1064. Br J Cancer. 1998 Nov;78(10):1269-77. [3]. Delaney CA, et al. Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines. Clin Cancer Res. 2000 Jul;6(7):2860-7. Chemical & Physical Properties Molecular Formula C9H8N2O2 Exact Mass 176.058578 PSA 65.98000 Appearance of Characters solid | off-white Index of Refraction 1.678 InChIKey YJDAOHJWLUNFLX-UHFFFAOYSA-N Safety Information Signal Word Warning Hazard Statements H302-H319 Precautionary Statements P305 + P351 + P338 Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves Hazard Codes Xn: Harmful; Risk Phrases 22 Safety Phrases 26 RIDADR NONH for all modes of transport WGK Germany 3 HS Code 2933990090 Synthetic Route 8-METHOXY-2-MET... CAS#:90915-45-0 CAS#:90417-38-2 Literature: Newcastle University Ventures Limited Patent: US6156739 A1, 2000 ; 3-METHOXY-2-AMI... CAS#:106782-78-9 CAS#:90417-38-2 Literature: Journal of Medicinal Chemistry, , vol. 41, # 26 p. 5247 - 5256 2-N-Acetylamino... CAS#:172462-98-5 CAS#:90417-38-2 Literature: Journal of Medicinal Chemistry, , vol. 41, # 26 p. 5247 - 5256 Precursor & DownStream Precursor 6 CAS#:90915-45-0 8-METHOXY-2-MET... CAS#:106782-78-9 3-METHOXY-2-AMI... CAS#:172462-98-5 2-N-Acetylamino... CAS#:16064-27-0 8-Methoxyquinaz... DownStream 1 CAS#:154288-10-5 4-CHLORO-2-METH... |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| Related Products in Pharmaceutical Intermediates | ||
|---|---|---|
| 9-Azabicyclo[3.3.1]nonan-3-amine, 69-methyl- | 1159976-88-1 | 2A-9062895 |
| 9-Azabicyclo[3.3.1]nonan-3-amine, 70-methyl- | 902644-30-8 | 2A-9062897 |
| 9-Azabicyclo[3.3.1]nonan-3-amine, 71-methyl- | 1086600-42-1 | 2A-9062899 |
| 9-Azabicyclo[3.3.1]nonan-3-amine, 74-methyl- | 23842-82-2 | 2A-9062901 |
| 9-Azabicyclo[3.3.1]nonan-3-amine, 75-methyl- | 219823-49-1 | 2A-9062903 |
| 9-Azabicyclo[3.3.1]nonan-3-amine, 76-methyl- | 190011-84-8 | 2A-9062905 |
| 9-Azabicyclo[3.3.1]nonan-3-amine, 77-methyl- | 316121-89-8 | 2A-9062907 |
| 9-Azabicyclo[3.3.1]nonan-3-amine, 78-methyl- | 20926-15-2 | 2A-9062909 |
| 9-Azabicyclo[3.3.1]nonan-3-amine, 79-methyl- | 69797-49-5 | 2A-9062910 |
| 9-Azabicyclo[3.3.1]nonan-3-amine, 81-methyl- | 79689-41-1 | 2A-9062911 |
| Browse all Pharmaceutical Intermediates products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS