CAS Number21392-57-4
Synonyms5,7-dimethoxy-2-phenyl-4H-1-benzopyran-4-one; Dimethylchrysin; Chrysin DME; 5,7-dimethoxyflavonone; MFCD00016943; 2-phenyl-5,7-dimethoxyl-flavone; 4H-1-Benzopyran-4-one,5,7-dimethoxy-2-phenyl; Chrysin 5,7-dimethyl ether; 5,7-DIMETHOXYFLAVONE; 5,7-dimethoxy-2-phenylchromen-4-one; 5,7-dimethoxycrysin; 5,7-dimethoxy-2-phenyl-chromen-4-one; 5,7-Dimethoxy-2-phenyl-4H-chromen-4-one; Chrysindimethylether; Chrysin dimethylether
Molecular FormulaC17H14O4
Molecular Weight282.29
Purity≥95.0 (HPLC)%
Density1.2±0.1 g/cm3
Boiling Point476.6±45.0 °C at 760 mmHg
Melting Point150-152ºC
Appearancesolid
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| Chemical & Physical Properties | |
|---|---|
| CAS Number | 21392-57-4 |
| Catalog No. | 2A-9006220 |
| Chinese Name | 柯因二甲醚 |
| Synonyms | 5,7-dimethoxy-2-phenyl-4H-1-benzopyran-4-one; Dimethylchrysin; Chrysin DME; 5,7-dimethoxyflavonone; MFCD00016943; 2-phenyl-5,7-dimethoxyl-flavone; 4H-1-Benzopyran-4-one,5,7-dimethoxy-2-phenyl; Chrysin 5,7-dimethyl ether; 5,7-DIMETHOXYFLAVONE; 5,7-dimethoxy-2-phenylchromen-4-one; 5,7-dimethoxycrysin; 5,7-dimethoxy-2-phenyl-chromen-4-one; 5,7-Dimethoxy-2-phenyl-4H-chromen-4-one; Chrysindimethylether; Chrysin dimethylether |
| Molecular Formula | C17H14O4 |
| Molecular Weight | 282.29 |
| Purity | ≥95.0 (HPLC) |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 476.6±45.0 °C at 760 mmHg |
| Melting Point | 150-152ºC |
| Appearance | solid |
| Storage Condition | 2-8℃, protected from light, sealed |
| Application | 5,7-Dimethoxyflavone is one of the main components of Kaempferia parviflora and has anti-obesity, anti-inflammatory and anti-tumor effects. 5,7-Dimethoxyflavone inhibits cytochrome P450 (CYP) 3As. 5,7 |
| HTC | 2914509090 |
| MDL Number | MFCD00016943 |
| SMILES | O1c2c(c(cc(c2)OC)OC)C(=O)C=C1c3ccccc3 |
| InChI | 1S/C17H14O4/c1-19-12-8-15(20-2)17-13(18)10-14(21-16(17)9-12)11-6-4-3-5-7-11/h3-10H,1-2H3 |
| InChI Key | JRFZSUMZAUHNSL-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/6220_1_21392_57_4.pdf |
| Use of | 5,7-Dimethoxyflavone is one of the major components of Kaempferia parviflora, has anti-obesity, anti-inflammatory, and antineoplastic effects. 5,7-Dimethoxyflavone inhibits cytochrome P450 (CYP) 3As. 5,7-Dimethoxyflavone is also a potent Breast Cancer Resistance Protein (BCRP) inhibitor[1][2]. Properties Name chrysin 5,7-dimethyl ether Synonym More Synonyms Chrysin dimethylether Biological Activity Description 5,7-Dimethoxyflavone is one of the major components of Kaempferia parviflora, has anti-obesity, anti-inflammatory, and antineoplastic effects. 5,7-Dimethoxyflavone inhibits cytochrome P450 (CYP) 3As. 5,7-Dimethoxyflavone is also a potent Breast Cancer Resistance Protein (BCRP) inhibitor[1][2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Research Areas >> Inflammation/Immunology Breast Cancer Resistance Protein (BCRP) References [1]. Ochiai W, et al. Effect of the active ingredient of Kaempferia parviflora, 5,7-dimethoxyflavone, on the pharmacokinetics of midazolam. J Nat Med. 2018 Jun;72(3):607-614. [2]. Bae S, et al. Effect of 5,7-dimethoxyflavone on Bcrp1-mediated transport of sorafenib in vitro and in vivo in mice. Eur J Pharm Sci. 2018 May 30;117:27-34. Chemical & Physical Properties Molecular Formula C17H14O4 Exact Mass 282.089203 PSA 48.67000 Index of Refraction 1.598 InChIKey JRFZSUMZAUHNSL-UHFFFAOYSA-N Safety Information HS Code 2914509090 Synthetic Route methyl iodide Chrysin dimethy... 21392-57-4 Literature: Wang, Cai-Ling; Zheng, Xing; Meng, Wei-Dong; Li, Hong-Qi; Qing, Feng-Ling Tetrahedron Letters, 2005 , vol. 46, # 32 p. 5399 - 5402 Flavokawain B Chrysin dimethy... 21392-57-4 Literature: Liu, Man; Zhang, Ji; Yang, Jian; Yang, Bo; Cui, Wei Journal of Chemical Research, 2014 , vol. 38, # 3 p. 134 - 136 Dimethyl sulfat... Chrysin dimethy... 21392-57-4 Literature: Righi, Giuliana; Antonioletti, Roberto; Silvestri, Ilaria Proietti; D'Antona, Nicola; Lambusta, Daniela; Bovicelli, Paolo Tetrahedron, 2010 , vol. 66, # 6 p. 1294 - 1298 Precursor & DownStream Precursor 10 CAS#:480-40-0 CAS#:74-88-4 methyl iodide CAS#:1775-97-9 Flavokawain B CAS#:77-78-1 Dimethyl sulfate DownStream 7 CAS#:480-40-0 CAS#:973-67-1 Baicalein-5,6,7... CAS#:89971-04-0 8-hydroxy-5,7-d... CAS#:1265223-29-7 4,6-dimethoxy-1... |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 5.5% Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0% |
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