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Home > Products > Specialty & Industrial Chemicals > Specialty Chemicals > Benzoic acid, 2-(acetyloxy)-, 4-(acetylamino)phenyl ester
Benzoic acid, 2-(acetyloxy)-, 4-(acetylamino)phenyl ester structure, CAS 5003-48-5

Benzoic acid, 2-(acetyloxy)-, 4-(acetylamino)phenyl ester

CAS Number5003-48-5

SynonymsFenasprate; 4'-(Acetamido)phenyl-2-acetoxybenzoate; Fenasparate; (1E)-N-{4-[(2-Acetoxybenzoyl)oxy]phenyl}ethanimidic acid; 4-Acetamidophenyl 2-acetoxybenzoate; p-Acetamidophenyl acetylsalicylate; Benzoic acid, 2-(acetyloxy)-, 4-[[(1E)-1-hydroxyethylidene]amino]phenyl ester; Benorilate; EINECS 225-674-5; 4-(acetylamino)phenyl 2-(acetyloxy)benzoate; Benorylate; MFCD00864257; Aspirin acetaminophen ester; (4-acetamidophenyl) 2-acetyloxybenzoate; Benzoic acid, 2-(acetyloxy)-, 4-(acetylamino)phenyl ester; 4-Acetamidophenyl salicylate acetate; Salipran

Molecular FormulaC17H15NO5

Molecular Weight313.313

Purity

Density1.2±0.1 g/cm3

Boiling Point511.5±60.0 °C at 760 mmHg

Melting Point177-181ºC

Flash Point

AppearanceSolid;White to Almost white powder to crystal

EINECS

MSDSChineseEnglish

Symbol

Signal Word

Cat. No.: 2A-9062194 Purity:
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Quality Control of [ 5003-48-5 ] SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number5003-48-5
Catalog No.2A-9062194
Chinese Name贝诺酯
SynonymsFenasprate; 4'-(Acetamido)phenyl-2-acetoxybenzoate; Fenasparate; (1E)-N-{4-[(2-Acetoxybenzoyl)oxy]phenyl}ethanimidic acid; 4-Acetamidophenyl 2-acetoxybenzoate; p-Acetamidophenyl acetylsalicylate; Benzoic acid, 2-(acetyloxy)-, 4-[[(1E)-1-hydroxyethylidene]amino]phenyl ester; Benorilate; EINECS 225-674-5; 4-(acetylamino)phenyl 2-(acetyloxy)benzoate; Benorylate; MFCD00864257; Aspirin acetaminophen ester; (4-acetamidophenyl) 2-acetyloxybenzoate; Benzoic acid, 2-(acetyloxy)-, 4-(acetylamino)phenyl ester; 4-Acetamidophenyl salicylate acetate; Salipran
Molecular FormulaC17H15NO5
Molecular Weight313.313
Density1.2±0.1 g/cm3
Boiling Point511.5±60.0 °C at 760 mmHg
Melting Point177-181ºC
AppearanceSolid;White to Almost white powder to crystal
Storage Conditionroom temperature
ApplicationBenorilate is an esterification product of acetaminophen and acetylsalicylic acid, which has anti-inflammatory, analgesic, and antipyretic effects. Benorilate also inhibits prostaglandin (PG) synthesi
HTC2924299090
MDL NumberMFCD00864257
SMILESCC(=O)Nc1ccc(OC(=O)c2ccccc2OC(C)=O)cc1
InChIInChI=1S/C17H15NO5/c1-11(19)18-13-7-9-14(10-8-13)23-17(21)15-5-3-4-6-16(15)22-12(2)20/h3-10H,1-2H3,(H,18,19)
InChI KeyFEJKLNWAOXSSNR-UHFFFAOYSA-N
MSDSmsds/62194_1_5003_48_5.pdf
Use ofBenorylate (Benoral) is the esterification product of paracetamol and acetylsalicylic acid. It has anti-inflammatory, analgesic and antipyretic properties. Benorylate could also inhibit prostaglandin (PG) synthesis. Properties Name 4-Acetamidophenyl 2-acetoxybenzoate Synonym More Synonyms Benorilate Biological Activity Description Benorylate (Benoral) is the esterification product of paracetamol and acetylsalicylic acid. It has anti-inflammatory, analgesic and antipyretic properties. Benorylate could also inhibit prostaglandin (PG) synthesis. Related Catalog Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor Research Areas >> Inflammation/Immunology Prostaglandin[4]. In Vitro Benorilate is an esterified aspirin preparation whose antirheumatic properties are reported to be as good as those of aspirin[1]. Benorylate causes a large decrease in the liver's conversion rate of lactate into glucose, an important component of glucose homeostasis. Benorylate also impairs the urea synthesis rate from ammonia, another important function of the liver[2]. In Vivo Benorylate is probably absorbed as the intact molecule which accounts for its good gastric tolerance[3]. Benorylate could inhibit PG synthesis in laboratory animals and in human tissue[4]. References [1]. Croft DN, et al. Gastric bleeding and benorylate, a new aspirin. Br Med J. 1972 Sep 2;3(5826):545-7. [2]. Castell JV, et al. Effects of benorylate and impacina on the metabolism of cultured hepatocytes. Xenobiotica. 1985 Aug-Sep;15(8-9):743-9. [3]. Wright V, et al. A review of benorylate - a new antirheumatic drug. Scand J Rheumatol Suppl. 1975;13:5-8. [4]. A. Bennett , et al. Inhibition of Prostaglandin Synthesis by Benorylate. Rheumatology, Volume XII, Issue suppl, 1 January 1973, Pages 101-105. Chemical & Physical Properties Molecular Formula C17H15NO5 Exact Mass 313.095032 PSA 81.70000 Index of Refraction 1.566 InChIKey FEJKLNWAOXSSNR-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Salicylic acid, acetate, ester with 4'-hydroxyacetanilide CAS REGISTRY NUMBER : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C17-H15-N-O5 MOLECULAR WEIGHT : WISWESSER LINE NOTATION : 1VOR BVOR DMV1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Human - woman DOSE/DURATION : TOXIC EFFECTS : Behavioral - hallucinations, distorted perceptions Lungs, Thorax, or Respiration - respiratory stimulation Nutritional and Gross Metabolic - dehydration REFERENCE : BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 288,1344,1984 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : EPXXDW European Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #0080609 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3431293 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 28,1692,1978 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3431293 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SEX/DURATION : female 7-17 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho, Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher information, see CGANE7. Volume(issue)/page/year: 20,143,1980 Safety Information Hazard Codes Xi HS Code 2924299090 Precursor & DownStream Precursor 0 DownStream 1 CAS#:118-57-0 acetaminosalol
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 30.0%
Transport InfoProduct name: Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
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