| Chemical & Physical Properties | |
|---|---|
| CAS Number | 6698-26-6 |
| Catalog No. | 2A-9006185 |
| Chinese Name | 2',5'-脱氧腺苷 |
| Synonyms | 2',5'-dideoxyadenosine |
| Molecular Formula | C10H13N5O2 |
| Molecular Weight | 235.24 |
| Purity | ≥95 (HPLC) |
| Density | 1.77 g/cm3 |
| Boiling Point | 547ºC at 760 mmHg |
| Appearance | solid |
| Storage Condition | -20°C |
| Application | 2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor that binds effectively to the P site with an IC50 of 3 µM. 2',5'-Dideoxyadenosine is a nucleoside analog that exerts p |
| HTC | 2934999090 |
| PubChem ID | 24894132 |
| MDL Number | MFCD00210904 |
| SMILES | C[C@H]1O[C@H](C[C@@H]1O)n2cnc3c(N)ncnc23 |
| InChI | 1S/C10H13N5O2/c1-5-6(16)2-7(17-5)15-4-14-8-9(11)12-3-13-10(8)15/h3-7,16H,2H2,1H3,(H2,11,12,13)/t5-,6+,7-/m1/s1 |
| InChI Key | FFHPXOJTVQDVMO-DSYKOEDSSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 41106305 |
| MSDS | msds/6185_1_6698_26_6.pdf |
| Use of | 2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor via binding the P-site with an IC50 of 3 µM . 2',5'-Dideoxyadenosine is a nucleoside analog and exerts a potent antiadrenergic action in heart[1][2]. Properties Articles32 Name 2′,5′-Dideoxyadenosine Synonym More Synonyms 2',5'-Dideoxyadenosine Biological Activity Description 2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor via binding the P-site with an IC50 of 3 µM . 2',5'-Dideoxyadenosine is a nucleoside analog and exerts a potent antiadrenergic action in heart[1][2]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Adenylate Cyclase Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Metabolic Disease IC50: 3 µM (adenylyl cyclase)[1] References [1]. Bushfield M, et al. Tissue levels, source, and regulation of 3'-AMP: an intracellular inhibitor of adenylyl cyclases. Mol Pharmacol. 1990 Dec;38(6):848-53. [2]. Hartmann M, et al. Isoproterenol antagonistic effect of 2',5'-dideoxyadenosine in the isolated perfused guinea-pig heart. J Mol Cell Cardiol. 1993 Mar;25(3):331-8. [4]. Leme Tdos S, et al. Role of prostaglandin/cAMP pathway in the diuretic and hypotensive effects of purified fraction of Maytenus ilicifolia Mart ex Reissek (Celastraceae). J Ethnopharmacol. 2013 Oct 28;150(1):154-61. Chemical & Physical Properties Molecular Formula C10H13N5O2 Exact Mass 235.10700 PSA 99.08000 LogP 0.65800 Index of Refraction 1.825 InChIKey FFHPXOJTVQDVMO-DSYKOEDSSA-N Safety Information Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter Hazard Codes Xi RIDADR NONH for all modes of transport HS Code 2934999090 Synthetic Route Total: 1 Page (2S,3S,5R)-5-(6... CAS#:108906-82-7 2',5'-Dideoxyad... CAS#:6698-26-6 Literature: Desaubry; Shoshani; Johnson Nucleosides and Nucleotides, 1995 , vol. 14, # 6 p. 1453 - 1460 2'-Deoxyadenosine CAS#:958-09-8 2',5'-Dideoxyad... CAS#:6698-26-6 Literature: Nucleosides and Nucleotides, , vol. 14, # 6 p. 1453 - 1460 Precursor & DownStream Precursor 2 CAS#:108906-82-7 (2S,3S,5R)-5-(6... CAS#:958-09-8 2'-Deoxyadenosine DownStream 2 CAS#:36792-88-8 2-Deoxy-β-D-rib... CAS#:73-24-5 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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