CAS Number321-64-2
SynonymsEINECS 206-291-2; MFCD00046923; 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE; 9-Amino-1,2,3,4-tetrahydroacridine; Tetrahydroaminocrine; Tenakrin; 1,2,3,4-tetrahydro-5-aminoacridine; Cognex; 4-Amino-2,3-tetramethylenequinoline; Tetrahydroaminocrin; 1,2,3,4-tetrahydro-9-amino-acridine; Tetrahydroaminacrine; 1,2,3,4-tetrahdyroacridin-9-amine; 1,2,3,4-tetrahydroacridin-9-amine; Romotal; Tetrahydroaminoacridine; Tacrine
Molecular FormulaC13H14N2
Molecular Weight198.27
Density1.3±0.1 g/cm3
Boiling Point353.8±42.0 °C at 760 mmHg
Melting Point283-284ºC
AppearanceWhite to yellow solid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 321-64-2 |
| Catalog No. | 2A-9061768 |
| Chinese Name | 他克林 |
| Synonyms | EINECS 206-291-2; MFCD00046923; 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE; 9-Amino-1,2,3,4-tetrahydroacridine; Tetrahydroaminocrine; Tenakrin; 1,2,3,4-tetrahydro-5-aminoacridine; Cognex; 4-Amino-2,3-tetramethylenequinoline; Tetrahydroaminocrin; 1,2,3,4-tetrahydro-9-amino-acridine; Tetrahydroaminacrine; 1,2,3,4-tetrahdyroacridin-9-amine; 1,2,3,4-tetrahydroacridin-9-amine; Romotal; Tetrahydroaminoacridine; Tacrine |
| Molecular Formula | C13H14N2 |
| Molecular Weight | 198.27 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 353.8±42.0 °C at 760 mmHg |
| Melting Point | 283-284ºC |
| Appearance | White to yellow solid |
| Storage Condition | Room temperature, dry, protected from light |
| Application | Tacrine is a potent acetylcholinesterase (AChE) inhibitor (IC50=109 nM) and can also be used as a CYP1A2 substrate drug. Tacrine exhibits some hepatotoxicity in some individuals. Tacrine can be used t |
| HTC | 2933990090 |
| MDL Number | MFCD00046923 |
| SMILES | Nc1c2c(nc3ccccc13)CCCC2 |
| InChI | InChI=1S/C13H14N2.ClH/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13;/h1,3,5,7H,2,4,6,8H2,(H2,14,15);1H |
| InChI Key | YLJREFDVOIBQDA-UHFFFAOYSA-N |
| MSDS | msds/61768_1_321_64_2.pdf |
| Bioactivity | Tacrine is a potent acetylcholinesterse (AChE) inhibitor (IC50=109 nM), also acting as a CYP1A2 substrate drug. Tacrine exhibits certain hepatotoxicity in some individuals. Tacrine can be used for researching Alzheimer's disease (AD)[1][2][3]. Related Catalog Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE Target IC50: 109 nM (AChE)[3] References [1]. Patocka J, et al. Possible role of hydroxylated metabolites of tacrine in drug toxicity and therapy of Alzheimer's disease. Curr Drug Metab. 2008;9(4):332-335. [2]. Bhatt S, et al. Assessment of the CYP1A2 Inhibition-Mediated Drug Interaction Potential for Pinocembrin Using In Silico, In Vitro, and In Vivo Approaches. ACS Omega. 2022;7(23):20321-20331. Published 2022 Jun 2. [3]. Romero A, et al. Novel tacrine-related drugs as potential candidates for the treatment of Alzheimer's disease. Bioorg Med Chem Lett. 2013;23(7):1916-1922. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 353.8±42.0 °C at 760 mmHg Melting Point 283-284ºC Molecular Formula C13H14N2 Molecular Weight 198.264 Flash Point 167.8±27.9 °C Exact Mass 198.115692 PSA 38.91000 LogP 1.78 Vapour Pressure 0.0±0.8 mmHg at 25°C Index of Refraction 1.682 InChIKey YLJREFDVOIBQDA-UHFFFAOYSA-N SMILES Nc1c2c(nc3ccccc13)CCCC2 |
| Use of | Tacrine is a potent acetylcholinesterse (AChE) inhibitor (IC50=109 nM), also acting as a CYP1A2 substrate drug. Tacrine exhibits certain hepatotoxicity in some individuals. Tacrine can be used for researching Alzheimer's disease (AD)[1][2][3]. Properties Name tacrine Synonym More Synonyms Tacrine Biological Activity Description Tacrine is a potent acetylcholinesterse (AChE) inhibitor (IC50=109 nM), also acting as a CYP1A2 substrate drug. Tacrine exhibits certain hepatotoxicity in some individuals. Tacrine can be used for researching Alzheimer's disease (AD)[1][2][3]. Related Catalog Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE IC50: 109 nM (AChE)[3] References [1]. Patocka J, et al. Possible role of hydroxylated metabolites of tacrine in drug toxicity and therapy of Alzheimer's disease. Curr Drug Metab. 2008;9(4):332-335. [2]. Bhatt S, et al. Assessment of the CYP1A2 Inhibition-Mediated Drug Interaction Potential for Pinocembrin Using In Silico, In Vitro, and In Vivo Approaches. ACS Omega. 2022;7(23):20321-20331. Published 2022 Jun 2. [3]. Romero A, et al. Novel tacrine-related drugs as potential candidates for the treatment of Alzheimer's disease. Bioorg Med Chem Lett. 2013;23(7):1916-1922. Chemical & Physical Properties Molecular Formula C13H14N2 Exact Mass 198.115692 PSA 38.91000 Index of Refraction 1.682 InChIKey YLJREFDVOIBQDA-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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