| Chemical & Physical Properties | |
|---|---|
| CAS Number | 781652-57-1 |
| Catalog No. | 2A-9061665 |
| Chinese Name | 3-氰基-N-(1,3-二苯基吡唑-5-基)苯甲酰胺 |
| Synonyms | CDPPB |
| Molecular Formula | C23H16N4O |
| Molecular Weight | 364.40 |
| Purity | ≥98 (HPLC) |
| Density | 1.203g/cm3 |
| Boiling Point | 523.277ºC at 760 mmHg |
| Appearance | powder |
| Storage Condition | 2-8°C, sealed, dry |
| Application | CDPPB is a potent, selective and brain-penetrating positive allosteric modulator of metabotropic glutamate receptor subtype 5 (mGluR5) with an EC50 of 27 nM in Chinese hamster ovary cells expressing h |
| PubChem ID | 329825248 |
| SMILES | O.O=C(Nc1cc(nn1-c2ccccc2)-c3ccccc3)c4cccc(c4)C#N |
| InChI | 1S/C23H16N4O.H2O/c24-16-17-8-7-11-19(14-17)23(28)25-22-15-21(18-9-3-1-4-10-18)26-27(22)20-12-5-2-6-13-20;/h1-15H,(H,25,28);1H2 |
| InChI Key | GZHZEGYXLNXEBV-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/61665_1_781652_57_1.pdf |
| Bioactivity | CDPPB is a potent, selective and brain penetrant positive allosteric modulator of the metabotropic glutamate receptor subtype 5 (mGluR5), with an EC50 of 27 nM in Chinese hamster ovary cells expressing human mGluR5. CDPPB may provide an approach for development of antipsychotic agents[1]. Related Catalog Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease Target mGluR5:27 nM (EC50) References [1]. Kinney GG, et, al. A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models. J Pharmacol Exp Ther. 2005 Apr; 313(1):199-206. Chemical & Physical Properties Density 1.203g/cm3 Boiling Point 523.277ºC at 760 mmHg Molecular Formula C23H16N4O Molecular Weight 364.39900 Flash Point 270.268ºC Exact Mass 364.13200 PSA 70.71000 LogP 4.73628 Index of Refraction 1.655 InChIKey BKUIZWILNWHFHD-UHFFFAOYSA-N SMILES N#Cc1cccc(C(=O)Nc2cc(-c3ccccc3)nn2-c2ccccc2)c1 |
| Use of | Properties Name 3-cyano-N-(2,5-diphenylpyrazol-3-yl)benzamide Synonym More Synonyms CDPPB Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease mGluR5:27 nM (EC50) References [1]. Kinney GG, et, al. A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models. J Pharmacol Exp Ther. 2005 Apr; 313(1):199-206. Chemical & Physical Properties Molecular Formula C23H16N4O Exact Mass 364.13200 PSA 70.71000 LogP 4.73628 Index of Refraction 1.655 InChIKey BKUIZWILNWHFHD-UHFFFAOYSA-N |
| Transport Info | Product name: 3-cyano-N-(1,3-diphenylpyrazol-5-yl)benzamide |
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