CAS Number1453-97-0
Synonyms5-benzyloxy-N,N-dimethylamino-3-methylindole; EINECS 215-927-8; 5-Benzyloxy-gramin; 5-Benzyloxygramine; MFCD00005631
Molecular FormulaC18H20N2O
Molecular Weight280.373
Purity98%
Density1.153g/cm3
Boiling Point442.3ºC at 760mmHg
Melting Point137-139 °C(lit.)
AppearanceWhite to off-white fine crystalline powder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1453-97-0 |
| Catalog No. | 2A-9061321 |
| Chinese Name | 5-苄氧基芦竹碱 |
| Synonyms | 5-benzyloxy-N,N-dimethylamino-3-methylindole; EINECS 215-927-8; 5-Benzyloxy-gramin; 5-Benzyloxygramine; MFCD00005631 |
| Molecular Formula | C18H20N2O |
| Molecular Weight | 280.373 |
| Purity | 98 |
| Density | 1.153g/cm3 |
| Boiling Point | 442.3ºC at 760mmHg |
| Melting Point | 137-139 °C(lit.) |
| Appearance | White to off-white fine crystalline powder |
| Storage Condition | Keep the container sealed and stored in a cool, dr |
| Application | 5-Benzyloxyglamin is an N protein PPI orthosteric stabilizer with antiviral and N-NTD protein stabilizing activity [1]. |
| HTC | 2933990090 |
| MDL Number | MFCD00005631 |
| SMILES | CN(C)Cc1c[nH]c2ccc(OCc3ccccc3)cc12 |
| InChI | InChI=1S/C18H20N2O/c1-20(2)12-15-11-19-18-9-8-16(10-17(15)18)21-13-14-6-4-3-5-7-14/h3-11,19H,12-13H2,1-2H3/p+1 |
| InChI Key | POTVAILTNPOQJH-UHFFFAOYSA-N |
| Hazard Symbols | transportation |
| MSDS | msds/61321_1_1453_97_0.pdf |
| Bioactivity | 5-Benzyloxygramine is a N protein PPI orthosteric stabilizer that exhibits both antiviral and N-NTD protein-stabilizing activities[1]. Related Catalog Research Areas >> Others Signaling Pathways >> Others >> Others In Vitro 5-benzyloxygramine stabilizes the N-NTD dimers through simultaneous hydrophobic interactions with both partners, resulting in abnormal N protein oligomerization that was further confirmed in the cell[1]. References [1]. Shan-Meng Lin, et al. Structure-Based Stabilization of Non-native Protein-Protein Interactions of Coronavirus Nucleocapsid Proteins in Antiviral Drug Design. J Med Chem. 2020 Mar 26;63(6):3131-3141. Chemical & Physical Properties Density 1.153g/cm3 Boiling Point 442.3ºC at 760mmHg Melting Point 137-139 °C(lit.) Molecular Formula C18H20N2O Molecular Weight 280.36400 Flash Point 221.3ºC Exact Mass 280.15800 PSA 28.26000 LogP 3.80850 Vapour Pressure 5.06E-08mmHg at 25°C InChIKey POTVAILTNPOQJH-UHFFFAOYSA-N SMILES CN(C)Cc1c[nH]c2ccc(OCc3ccccc3)cc12 Storage condition 2-8°C |
| Use of | 5-Benzyloxygramine is a N protein PPI orthosteric stabilizer that exhibits both antiviral and N-NTD protein-stabilizing activities[1]. Properties Name N,N-dimethyl-1-(5-phenylmethoxy-1H-indol-3-yl)methanamine Synonym More Synonyms 5-benzyloxygramine Biological Activity Description 5-Benzyloxygramine is a N protein PPI orthosteric stabilizer that exhibits both antiviral and N-NTD protein-stabilizing activities[1]. Related Catalog Research Areas >> Others Signaling Pathways >> Others >> Others In Vitro 5-benzyloxygramine stabilizes the N-NTD dimers through simultaneous hydrophobic interactions with both partners, resulting in abnormal N protein oligomerization that was further confirmed in the cell[1]. References [1]. Shan-Meng Lin, et al. Structure-Based Stabilization of Non-native Protein-Protein Interactions of Coronavirus Nucleocapsid Proteins in Antiviral Drug Design. J Med Chem. 2020 Mar 26;63(6):3131-3141. Chemical & Physical Properties Molecular Formula C18H20N2O Exact Mass 280.15800 PSA 28.26000 LogP 3.80850 InChIKey POTVAILTNPOQJH-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available The above information is believed to be correct, but is not all-inclusive and should be used as a guide only. The information in this document is based on our current knowledge and is Correct safety instructions apply to this product. This information does not represent a warranty as to the properties of this product. See reverse side of invoice or packing slip. |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| 1,2,3-TRIFLUOROPROPANE | 66794-36-3 | 2A-9061308 |
| 1,1,3-TRIFLUOROPROPANE | 24270-67-5 | 2A-9061309 |
| (4-FLUORO-1H-INDOL-3-YL)-ACETIC ACID | 89434-03-7 | 2A-9061315 |
| 4-METHYLGRAMINE | 164119-81-7 | 2A-9061318 |
| 5-AMINOGRAMINE | 3414-74-2 | 2A-9061320 |
| 6-BENZYLOXYGRAMINE | 57765-22-7 | 2A-9061323 |
| 7-BENZYLOXYGRAMINE | 94067-27-3 | 2A-9061327 |
| (7-BENZYLOXY-1H-INDOL-3-YL)-ACETIC ACID | 99102-25-7 | 2A-9061328 |
| (7-methyl-1H-indol-3-yl)acetonitrile | 858232-97-0 | 2A-9061331 |
| Potassium saccharate | 10332-51-1 | 2A-9061334 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS