EN
0
Home > Products > Specialty & Industrial Chemicals > Specialty Chemicals > HYDROXYFLUTAMIDE
HYDROXYFLUTAMIDE structure, CAS 52806-53-8

HYDROXYFLUTAMIDE

CAS Number52806-53-8

Synonyms2-hydroxy Flutamide; 2-Hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide; 2-Hydroxy-2-methyl-N-(4-nitro-3-(trifluoromethyl)phenyl)propanamide; Hydroxyflutamide; 2-Hydroxy-flutamide

Molecular FormulaC11H11F3N2O4

Molecular Weight292.21

Purity≥98 (HPLC)%

Density1.5±0.1 g/cm3

Boiling Point443.8±45.0 °C at 760 mmHg

Melting Point125-130℃

Flash Point

Appearancepowder

EINECS

MSDSChineseEnglish

Symboltransportation

Signal WordWarning

Cat. No.: 2A-9061275 Purity: ≥98 (HPLC)%
Change View

Please Login or Create an Account to: See VlP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

Inquiry

Quality Control of [ 52806-53-8 ] Purity: ≥98 (HPLC)% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number52806-53-8
Catalog No.2A-9061275
Chinese Name羟基氟他胺
Synonyms2-hydroxy Flutamide; 2-Hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide; 2-Hydroxy-2-methyl-N-(4-nitro-3-(trifluoromethyl)phenyl)propanamide; Hydroxyflutamide; 2-Hydroxy-flutamide
Molecular FormulaC11H11F3N2O4
Molecular Weight292.21
Purity≥98 (HPLC)
Density1.5±0.1 g/cm3
Boiling Point443.8±45.0 °C at 760 mmHg
Melting Point125-130℃
Appearancepowder
Storage ConditionKeep the container sealed and stored in a cool, dr
ApplicationHydroxoflutamide (HF) is the active metabolite of flutamide and a potent androgen receptor antagonist (IC50=700nm). Hydroxyflutamide can be used in prostate cancer research[1][2].
HTC2924299090
PubChem ID329815208
MDL NumberMFCD00563126
SMILESCC(C)(O)C(=O)Nc1ccc(c(c1)C(F)(F)F)[N+]([O-])=O
InChI1S/C11H11F3N2O4/c1-10(2,18)9(17)15-6-3-4-8(16(19)20)7(5-6)11(12,13)14/h3-5,18H,1-2H3,(H,15,17)
InChI KeyYPQLFJODEKMJEF-UHFFFAOYSA-N
NACRES CodeNA.77
UNSPSC51111800
Hazard Symbolstransportation
MSDSmsds/61275_1_52806_53_8.pdf
BioactivityHydroxyflutamide (HF), an active metabolite of Flutamide, is a potent androgen receptor antagonist (IC50=700 nM). Hydroxyflutamide can be used for the research of prostate cancer[1][2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Others >> Androgen Receptor Target IC50: 700 nM (androgen receptor)[1] References [1]. Furr BJ, et, al. Casodex: preclinical studies and controversies. Ann N Y Acad Sci. 1995 Jun 12;761:79-96. [2]. Liu HL, et, al. A Molecular Modeling Study of the Hydroxyflutamide Resistance Mechanism Induced by Androgen Receptor Mutations. Int J Mol Sci. 2017 Aug 23;18(9):1823. Chemical & Physical Properties Density 1.5±0.1 g/cm3 Boiling Point 443.8±45.0 °C at 760 mmHg Melting Point 125-130℃ Molecular Formula C11H11F3N2O4 Molecular Weight 292.211 Flash Point 222.2±28.7 °C Exact Mass 292.067078 PSA 95.15000 LogP 3.16 Vapour Pressure 0.0±1.1 mmHg at 25°C Index of Refraction 1.546 InChIKey YPQLFJODEKMJEF-UHFFFAOYSA-N SMILES CC(C)(O)C(=O)Nc1ccc([N+](=O)[O-])c(C(F)(F)F)c1
Use ofHydroxyflutamide (HF), an active metabolite of Flutamide, is a potent androgen receptor antagonist (IC50=700 nM). Hydroxyflutamide can be used for the research of prostate cancer[1][2]. Properties Articles34 Name Hydroxy Flutamide Synonym More Synonyms 2-Hydroxyflutamide Biological Activity Description Hydroxyflutamide (HF), an active metabolite of Flutamide, is a potent androgen receptor antagonist (IC50=700 nM). Hydroxyflutamide can be used for the research of prostate cancer[1][2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Others >> Androgen Receptor IC50: 700 nM (androgen receptor)[1] References [1]. Furr BJ, et, al. Casodex: preclinical studies and controversies. Ann N Y Acad Sci. 1995 Jun 12;761:79-96. [2]. Liu HL, et, al. A Molecular Modeling Study of the Hydroxyflutamide Resistance Mechanism Induced by Androgen Receptor Mutations. Int J Mol Sci. 2017 Aug 23;18(9):1823. Chemical & Physical Properties Molecular Formula C11H11F3N2O4 Exact Mass 292.067078 PSA 95.15000 Index of Refraction 1.546 InChIKey YPQLFJODEKMJEF-UHFFFAOYSA-N
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 30.0%
Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available
Related Products in Specialty Chemicals
N-Ethylbuphedrone1354631-28-92A-9061260
3-BROMO-4-METHYLPHENOL60710-39-62A-9061262
(3-Bromo-2-fluoro-phenyl)-acetic acid786652-63-92A-9061267
LSD; Diethylamid kyseliny lysergove50-37-32A-9061273
O-(D-Glucopyranosylidene)amino N-Phenylcarbamate104012-84-22A-9061274
2-bromo-4'-chloro-2'-(o-fluorobenzoyl)acetanilide1584-62-92A-9061276
2-METHYLPROPYLHYDRAZINEHYDROCHLORIDE 237064-47-02A-9061277
3-Methyladipic acid3058-01-32A-9061280
1,2-DIBROMOFLUOROETHANE358-97-42A-9061284
DL-METHIONINE METHYLSULFONIUM CHLORIDE1115-84-02A-9061285
Browse all Specialty Chemicals products »
Contact Us

Phone:

630-322-8886

630-322-8887

Email:

[email protected]

Office Locations:

Chicago, IL, USA

San Francisco, CA, USA