CAS Number67165-56-4
Synonyms(±)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-7-methoxy-2-methylisoquinoline; (±)-4-(3,4-dichlorophenyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline; 4-(3,4-dichlorophenyl)-7-methoxy-2-methyl-3,4-dihydro-1H-isoquinoline; Ro 8-4650; Diclofensine; 4-(3,4-Dichlorophenyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline
Molecular FormulaC17H17Cl2NO
Molecular Weight322.23
Purity98%%
Density1.2±0.1 g/cm3
Boiling Point422.6±45.0 °C at 760 mmHg
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 67165-56-4 |
| Catalog No. | 2A-9061256 |
| Chinese Name | (±)-双氮奋兴 |
| Synonyms | (±)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-7-methoxy-2-methylisoquinoline; (±)-4-(3,4-dichlorophenyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline; 4-(3,4-dichlorophenyl)-7-methoxy-2-methyl-3,4-dihydro-1H-isoquinoline; Ro 8-4650; Diclofensine; 4-(3,4-Dichlorophenyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline |
| Molecular Formula | C17H17Cl2NO |
| Molecular Weight | 322.23 |
| Purity | 98% |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 422.6±45.0 °C at 760 mmHg |
| Storage Condition | 2-8℃ |
| Application | Diclofensine (Ro-8-4650) is a highly effective monoamine reuptake inhibitor with IC50 values of 0.74, 2.3 and 3.7 nM for blocking dopamine, norepinephrine and serotonin in rat brain synaptosomes, re |
| HTC | 2933499090 |
| MDL Number | C17H17Cl2NO |
| SMILES | [H+].[Cl-].COc1ccc2C(CN(C)Cc2c1)c3ccc(Cl)c(Cl)c3 |
| InChI | InChI=1S/C17H17Cl2NO.ClH/c1-20-9-12-7-13(21-2)4-5-14(12)15(10-20)11-3-6-16(18)17(19)8-11;/h3-8,15H,9-10H2,1-2H3;1H |
| InChI Key | InChIKey=PEHOXCSPLOXNOK-UHFFFAOYSA-N |
| MSDS | msds/61256_1_67165_56_4.pdf |
| Use of | Properties Name 4-(3,4-Dichlorophenyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline Synonym More Synonyms Diclofensine Biological Activity Related Catalog Signaling Pathways >> Neuronal Signaling >> Dopamine Transporter Research Areas >> Neurological Disease References [1]. Hyttel J, et al. Neurochemical profile of Lu 19-005, a potent inhibitor of uptake of dopamine, noradrenaline, and serotonin. J Neurochem. 1985 May;44(5):1615-22. [2]. Gasic S, et al. Effect of diclofensine, a novel antidepressant, on peripheral adrenergic function. Clin Pharmacol Ther. 1986 May;39(5):582-5. [3]. Di Renzo G, et al. Pure uptake blockers of dopamine can reduce prolactin secretion: studies with diclofensine. Life Sci. 1988;42(21):2161-9. Chemical & Physical Properties Exact Mass 321.068726 PSA 12.47000 Index of Refraction 1.591 Storage condition 2-8℃ Safety Information HS Code 2933499090 Precursor & DownStream Precursor 1 CAS#:802051-24-7 3,4-Dichloro-α-... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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