CAS Number96020-91-6
Synonyms2,5-diamino-2-(difluoromethyl)pentanoic acid,hydrate,hydrochloride; Eflornithine (hydrochloride, hydrate)
Molecular FormulaC6H15ClF2N2O3
Molecular Weight236.64500
Purity98%
Density1.293g/cm3
Boiling Point347ºC at 760mmHg
Melting Point>210ºC (dec.)
Appearancewhite solid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 96020-91-6 |
| Catalog No. | 2A-9061239 |
| Chinese Name | 依氟鸟氨酸盐酸盐一水合物 |
| Synonyms | 2,5-diamino-2-(difluoromethyl)pentanoic acid,hydrate,hydrochloride; Eflornithine (hydrochloride, hydrate) |
| Molecular Formula | C6H15ClF2N2O3 |
| Molecular Weight | 236.64500 |
| Purity | 98 |
| Density | 1.293g/cm3 |
| Boiling Point | 347ºC at 760mmHg |
| Melting Point | >210ºC (dec.) |
| Appearance | white solid |
| Storage Condition | 2~8°C |
| Application | Eflornithine hydrochloride, hydrate is a specific and irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine hydrochloride, hydrate is a drug used to treat African trypanosomiasis |
| HTC | 2922499990 |
| SMILES | Cl.NCCCC(N)(C(=O)O)C(F)F.O |
| InChI | InChI=1S/C6H12F2N2O2.ClH.H2O/c7-4(8)6(10,5(11)12)2-1-3-9;;/h4H,1-3,9-10H2,(H,11,12);1H;1H2 |
| InChI Key | FJPAMFNRCFEGSD-UHFFFAOYSA-N |
| Bioactivity | Eflornithine hydrochloride, hydrate is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Others In Vivo Eflornithine is the only new molecule registered for the treatment of human African trypanosomiasis over the last 50 years. It is the drug used mainly as a back-up for melarsoprol refractory Trypanosoma brucei gambiense cases[1]. In subjects with excessive, unwanted facial hair, eflornithine 15% cream is superior to placebo in reducing hair growth. After 24 weeks' treatment, 58% of eflornithine and 34% of placebo subjects have at least some improvement in facial hirsutism[2]. The hair growth inhibitory activity of eflornithine is significantly enhanced when the eflornithine cream is applied onto a mouse skin area pretreated with microneedles[3]. Treatment of coarctation hypertensive rats with eflornithine results in a normalization of the contractile intensity to KCI and norepinephrine and relaxations to acetylcholine by 14 days of hypertension[4]. Animal Admin Mice: The skin area where the hair is removed is then treated with the eflornithine hydrochloride 13.9% cream (-50 mg per mouse per treatment) using a spatula 2 times a day in an interval of at least 8 h for a maximum period of 36 days[3]. References [1]. Burri C, et al. Eflornithine for the treatment of human African trypanosomiasis. Parasitol Res. 2003 Jun;90 Supp 1:S49-52. [2]. Balfour JA, et al. Topical eflornithine. Am J Clin Dermatol. 2001;2(3):197-201; discussion 202. [3]. Kumar A, et al. A method to improve the efficacy of topical eflornithine hydrochloride cream. Drug Deliv. 2016 Jun;23(5):1495-501. [4]. Lipke DW, et al. Eflornithine alters changes in vascular responsiveness associated with coarctation hypertension. Clin Exp Hypertens. 1997 Apr;19(3):297-312. Chemical & Physical Properties Density 1.293g/cm3 Boiling Point 347ºC at 760mmHg Melting Point >210ºC (dec.) Molecular Formula C6H15ClF2N2O3 Molecular Weight 236.64500 Flash Point 163.7ºC Exact Mass 236.07400 PSA 98.57000 LogP 1.91080 InChIKey FJPAMFNRCFEGSD-UHFFFAOYSA-N SMILES Cl.NCCCC(N)(C(=O)O)C(F)F.O Storage condition 2~8°C |
| Use of | Eflornithine hydrochloride, hydrate is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women. Properties Name DL-α-Difluoromethylornithine Hydrochloride Monohydrate Synonym More Synonyms Eflornithine (hydrochloride, hydrate) Biological Activity Description Eflornithine hydrochloride, hydrate is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Others In Vivo Eflornithine is the only new molecule registered for the treatment of human African trypanosomiasis over the last 50 years. It is the drug used mainly as a back-up for melarsoprol refractory Trypanosoma brucei gambiense cases[1]. In subjects with excessive, unwanted facial hair, eflornithine 15% cream is superior to placebo in reducing hair growth. After 24 weeks' treatment, 58% of eflornithine and 34% of placebo subjects have at least some improvement in facial hirsutism[2]. The hair growth inhibitory activity of eflornithine is significantly enhanced when the eflornithine cream is applied onto a mouse skin area pretreated with microneedles[3]. Treatment of coarctation hypertensive rats with eflornithine results in a normalization of the contractile intensity to KCI and norepinephrine and relaxations to acetylcholine by 14 days of hypertension[4]. References [1]. Burri C, et al. Eflornithine for the treatment of human African trypanosomiasis. Parasitol Res. 2003 Jun;90 Supp 1:S49-52. [2]. Balfour JA, et al. Topical eflornithine. Am J Clin Dermatol. 2001;2(3):197-201; discussion 202. [3]. Kumar A, et al. A method to improve the efficacy of topical eflornithine hydrochloride cream. Drug Deliv. 2016 Jun;23(5):1495-501. [4]. Lipke DW, et al. Eflornithine alters changes in vascular responsiveness associated with coarctation hypertension. Clin Exp Hypertens. 1997 Apr;19(3):297-312. Chemical & Physical Properties Exact Mass 236.07400 PSA 98.57000 LogP 1.91080 InChIKey FJPAMFNRCFEGSD-UHFFFAOYSA-N SMILES Cl.NCCCC(N)(C(=O)O)C(F)F.O |
| Tax Rebate | 9.0% |
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| Inspection | P. Quarantine of entry animals, plants, and animal and plant products Q. Quarantine of exit animals, plants, and animal and plant products R. Hygiene supervision and inspection of imported food S. Hyg |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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