CAS Number127828-22-2
SynonymsAmbotzPEG1067; 1-t-butoxycarbonylamino-3-oxa-pentan-5-amine; N-Boc-2-(2-amino-ethoxy)-ethylamine; tert-butyl 2-(2-aminoethoxy)ethylcarbamate; N-(tert-butyloxycarbonyl)-2,2'-oxybis(ethylamine); 5-(tert-butyloxycarbonylamino)-3-oxa-pentyl amine; N-t-butoxycarbonyl-3-oxa-1,5-pentanediamine; tert-Butyl [2-(2-aminoethoxy)ethyl]carbamate
Molecular FormulaC9H20O3N2
Molecular Weight204.27
Purity98%
Density1.024g/cm3
Boiling Point321.128ºC at 760 mmHg
AppearanceLiquid;Colorless to Light orange to Yellow clear liquid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 127828-22-2 |
| Catalog No. | 2A-9060991 |
| Chinese Name | [2-(2-氨基乙氧基)乙基]氨基甲酸叔丁酯 |
| Synonyms | AmbotzPEG1067; 1-t-butoxycarbonylamino-3-oxa-pentan-5-amine; N-Boc-2-(2-amino-ethoxy)-ethylamine; tert-butyl 2-(2-aminoethoxy)ethylcarbamate; N-(tert-butyloxycarbonyl)-2,2'-oxybis(ethylamine); 5-(tert-butyloxycarbonylamino)-3-oxa-pentyl amine; N-t-butoxycarbonyl-3-oxa-1,5-pentanediamine; tert-Butyl [2-(2-aminoethoxy)ethyl]carbamate |
| Molecular Formula | C9H20O3N2 |
| Molecular Weight | 204.27 |
| Purity | 98 |
| Density | 1.024g/cm3 |
| Boiling Point | 321.128ºC at 760 mmHg |
| Appearance | Liquid;Colorless to Light orange to Yellow clear liquid |
| Water Solubility | Soluble (53 g/L) (25 ºC) |
| Storage Condition | Store under inert gas; avoid air |
| Application | Amino-PEG2-NH-Boc is a PEG-based PROTAC bridge used to synthesize PROTAC. |
| HTC | 2924199090 |
| MDL Number | MFCD12031501 |
| SMILES | CC(C)(C)OC(=O)NCCOCCN |
| InChI Key | VULKFBHOEKTQSF-UHFFFAOYSA-N |
| MSDS | msds/60991_1_127828_22_2.pdf |
| Use of | Amino-PEG2-NH-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Properties Name tert-butyl N-[2-(2-aminoethoxy)ethyl]carbamate Synonym More Synonyms Amino-PEG2-NH-Boc Biological Activity Description Amino-PEG2-NH-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker Alkyl/ether In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. References [1]. Qiu X, et al. Chemoselective Synthesis of Lenalidomide-Based PROTAC Library Using Alkylation Reaction. Org Lett. 2019 May 17;21(10):3838-3841. Chemical & Physical Properties Molecular Formula C9H20N2O3 Exact Mass 204.14700 PSA 77.07000 LogP 1.39110 Index of Refraction 1.457 InChIKey VULKFBHOEKTQSF-UHFFFAOYSA-N SMILES CC(C)(C)OC(=O)NCCOCCN Safety Information Hazard Codes Xi HS Code 2924199090 Synthetic Route CAS#:176220-30-7 Amino-PEG2-NH-Boc CAS#:127828-22-2 Literature: EP1745802 A1, ; Page/Page column 17 ; Di-tert-butyl d... CAS#:24424-99-5 2,2'-Oxydiethan... CAS#:60792-79-2 Amino-PEG2-NH-Boc CAS#:127828-22-2 Literature: Journal of Organic Chemistry, , vol. 72, # 7 p. 2289 - 2296 2,2-Oxybis(ethy... CAS#:2752-17-2 Di-tert-butyl d... CAS#:24424-99-5 Amino-PEG2-NH-Boc CAS#:127828-22-2 Literature: Tetrahedron Letters, , vol. 47, # 17 p. 2915 - 2919 Precursor & DownStream Precursor 6 CAS#:24424-99-5 Di-tert-butyl d... CAS#:60792-79-2 2,2'-Oxydiethan... CAS#:2752-17-2 2,2-Oxybis(ethy... CAS#:1046804-80-1 Tert-butyl 2-(2... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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