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Home > Products > Agrochemicals > Agrochemical Intermediates > N2-[4-(Aminomethyl)phenyl]-5-fluoro-N4-phenylpyrimidine-2,4-diamine
N2-[4-(Aminomethyl)phenyl]-5-fluoro-N4-phenylpyrimidine-2,4-diamine structure, CAS 916603-07-1

N2-[4-(Aminomethyl)phenyl]-5-fluoro-N4-phenylpyrimidine-2,4-diamine

CAS Number916603-07-1

SynonymsN-[4-(Aminomethyl)phenyl]-5-fluoro-N-phenyl-2,4-pyrimidinediamine; CZC8004; 2-N-[4-(aminomethyl)phenyl]-5-fluoro-4-N-phenylpyrimidine-2,4-diamine

Molecular FormulaC17H16FN5

Molecular Weight309.35

Purity98%

Density1.3±0.1 g/cm3

Boiling Point514.1±60.0 °C at 760 mmHg

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Flash Point

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Cat. No.: 2A-9060983 Purity: 98%
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Quality Control of [ 916603-07-1 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number916603-07-1
Catalog No.2A-9060983
Chinese NameN2-[4-(氨基甲基)苯基]-5-氟-N4-苯基嘧啶-2,4-二胺
SynonymsN-[4-(Aminomethyl)phenyl]-5-fluoro-N-phenyl-2,4-pyrimidinediamine; CZC8004; 2-N-[4-(aminomethyl)phenyl]-5-fluoro-4-N-phenylpyrimidine-2,4-diamine
Molecular FormulaC17H16FN5
Molecular Weight309.35
Purity98
Density1.3±0.1 g/cm3
Boiling Point514.1±60.0 °C at 760 mmHg
Storage Condition2-8°C, protected from light, stored in inert gas
ApplicationCZC-8004 is a broad kinase inhibitor that binds to multiple tyrosine kinases, including ABL kinase.
HTC2921499090
MDL NumberC17H16FN5
SMILESNCc1ccc(Nc2ncc(F)c(Nc3ccccc3)n2)cc1
InChI KeyUKOHFWNBTUJMMN-UHFFFAOYSA-N
MSDSmsds/60983_1_916603_07_1.pdf
Use ofCZC-8004 is a pan-kinase inhibitor and binds a range of tyrosine kinases, including ABL kinase. Properties Name N2-(4-(Aminomethyl)phenyl)-5-fluoro-N4-phenylpyrimidine-2,4-diamine Synonym More Synonyms CZC8004 Biological Activity Description CZC-8004 is a pan-kinase inhibitor and binds a range of tyrosine kinases, including ABL kinase. Related Catalog Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Bcr-Abl Research Areas >> Cancer References [1]. CZC-8004 is a pan-kinase inhibitor, with low micromolar IC50 values for tyrosine kinase. [2]. Bantscheff M, et al. Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors. Nat Biotechnol. 2007 Sep;25(9):1035-44. Chemical & Physical Properties Molecular Formula C17H16FN5 Exact Mass 309.138977 PSA 75.86000 Index of Refraction 1.699 InChIKey UKOHFWNBTUJMMN-UHFFFAOYSA-N Safety Information HS Code 2921499090 Synthetic Route Total: 1 Page [4-(5-Fluoro-4-... CAS#:916603-12-8 CAS#:916603-07-1
Tax Rebate9.0%
SupervisionNone MFN tariff: 6.5% Ordinary tariff: 30.0%
Transport InfoProduct name: Summary 2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%
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