CAS Number135729-62-3
SynonymsPalonosetron Hydrochloride; RS 25259-197; (3aS)-2,3,3a,4,5,6-Hexahydro-2-[(3S)-3-quinuclidinyl]-1H-benz[de]isoquinolin-1-one Monohydrochloride; MFCD07370072; (3aS)-2-(S)-1-Azabicyclo[2,2,2]oct-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benz(d)isoquinolin-1-one; Palonosetron (Hydrochloride)
Molecular FormulaC19H25ClN2O
Molecular Weight332.87
Purity98%
Boiling Point470.4ºC at 760 mmHg
Melting Point>290ºC
Appearancewhite solid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 135729-62-3 |
| Catalog No. | 2A-9060754 |
| Chinese Name | 盐酸帕洛诺司琼 |
| Synonyms | Palonosetron Hydrochloride; RS 25259-197; (3aS)-2,3,3a,4,5,6-Hexahydro-2-[(3S)-3-quinuclidinyl]-1H-benz[de]isoquinolin-1-one Monohydrochloride; MFCD07370072; (3aS)-2-(S)-1-Azabicyclo[2,2,2]oct-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benz(d)isoquinolin-1-one; Palonosetron (Hydrochloride) |
| Molecular Formula | C19H25ClN2O |
| Molecular Weight | 332.87 |
| Purity | 98 |
| Boiling Point | 470.4ºC at 760 mmHg |
| Melting Point | >290ºC |
| Appearance | white solid |
| Storage Condition | Refrigerator |
| Application | Palonosetron hydrochloride is a 5-HT3 antagonist that inhibits chemotherapy-induced nausea and vomiting (CINV). |
| HTC | 2933990090 |
| MDL Number | C19H24N2O·HCl |
| SMILES | Cl.O=C1c2cccc3c2C(CCC3)CN1C1CN2CCC1CC2 |
| InChI | InChI=1S/C19H24N2O.ClH/c22-19-16-6-2-4-14-3-1-5-15(18(14)16)11-21(19)17-12-20-9-7-13(17)8-10-20;/h2,4,6,13,15,17H,1,3,5,7-12H2;1H/t15-,17+;/m0./s1 |
| InChI Key | OLDRWYVIKMSFFB-SSPJITILSA-N |
| MSDS | msds/60754_1_135729_62_3.pdf |
| Bioactivity | Palonosetron Hcl is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV).IC50 Value:Target: 5-HT ReceptorPalonosetron is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first dose of a course of chemotherapy. Related Catalog Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Research Areas >> Cardiovascular Disease References [1]. Vishnu Murthy M, Srinivas K, Kumar R, Mukkanti K. Development and validation of a stability-indicating LC method for determining palonosetron hydrochloride, its related compounds and degradation products using naphthalethyl stationary phase. J Pharm Bio [2]. Ajioka H, Morita F, Akizawa Y, Yoshida K, Kitamura R, Takimoto H. Pharmacological, pharmacokinetic, and clinical profile of palonosetron hydrochloride (ALOXI I.V. Injection 0.75 mg), a novel antiemetic 5-HT3-receptor antagonist.Nihon Yakurigaku Zasshi. 2 [3]. Ruhlmann C, Herrstedt J. Palonosetron hydrochloride for the prevention of chemotherapy-induced nausea and vomiting. Expert Rev Anticancer Ther. 2010 Feb;10(2):137-48. [4]. Trissel LA, Trusley C, Ben M, Kupiec TC. Physical and chemical stability of palonosetron hydrochloride with five opiate agonists during simulated Y-site administration. Am J Health Syst Pharm. 2007 Jun 1;64(11):1209-13. [5]. Clark, Robin D.; Miller, Aaron B.; Berger, Jacob; Repke, David B.; Weinhardt, Klaus K.; Kowalczyk, Bruce A.; Eglen, Richard M.; Bonhaus, Douglas W.; Lee, Chi Ho; et al.2-(Quinuclidin-3-yl)pyrido[4,3-b]indol-1-ones and isoquinolin-1-ones. Potent conformati Chemical & Physical Properties Boiling Point 470.4ºC at 760 mmHg Melting Point >290ºC Molecular Formula C19H25ClN2O Molecular Weight 332.868 Flash Point 209.5ºC Exact Mass 332.165527 PSA 23.55000 LogP 3.33430 Vapour Pressure 5.07E-09mmHg at 25°C InChIKey OLDRWYVIKMSFFB-SSPJITILSA-N SMILES Cl.O=C1c2cccc3c2C(CCC3)CN1C1CN2CCC1CC2 Storage condition Refrigerator |
| Use of | Palonosetron Hcl is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV).IC50 Value:Target: 5-HT ReceptorPalonosetron is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first dose of a course of chemotherapy. Properties Name palonosetron hydrochloride Synonym More Synonyms Palonosetron hydrochloride Biological Activity Description Palonosetron Hcl is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV).IC50 Value:Target: 5-HT ReceptorPalonosetron is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first dose of a course of chemotherapy. Related Catalog Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Research Areas >> Cardiovascular Disease References [1]. Vishnu Murthy M, Srinivas K, Kumar R, Mukkanti K. Development and validation of a stability-indicating LC method for determining palonosetron hydrochloride, its related compounds and degradation products using naphthalethyl stationary phase. J Pharm Bio [3]. Ruhlmann C, Herrstedt J. Palonosetron hydrochloride for the prevention of chemotherapy-induced nausea and vomiting. Expert Rev Anticancer Ther. 2010 Feb;10(2):137-48. [4]. Trissel LA, Trusley C, Ben M, Kupiec TC. Physical and chemical stability of palonosetron hydrochloride with five opiate agonists during simulated Y-site administration. Am J Health Syst Pharm. 2007 Jun 1;64(11):1209-13. [5]. Clark, Robin D.; Miller, Aaron B.; Berger, Jacob; Repke, David B.; Weinhardt, Klaus K.; Kowalczyk, Bruce A.; Eglen, Richard M.; Bonhaus, Douglas W.; Lee, Chi Ho; et al.2-(Quinuclidin-3-yl)pyrido[4,3-b]indol-1-ones and isoquinolin-1-ones. Potent conformati Chemical & Physical Properties Exact Mass 332.165527 PSA 23.55000 LogP 3.33430 InChIKey OLDRWYVIKMSFFB-SSPJITILSA-N Storage condition Refrigerator |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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