CAS Number6893-02-3
Synonyms3,3',5 TRIIODOTHYRONINE (T3), IRMM STANDARD; 3,5,3′-tri-iodo-l-thyronine; Liothyronine (T3); T3, O-(4-HYDROXY-3-IODOPHENYL)-3,5-DIIODO-L-TYROSINE; O-(4-Hydroxy-3-iodophenyl)-3,5-diiodotyrosine; L T3; O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine; 3,3',5-Triiodothyronine; Triiodothyronine; L-3-[4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodophenyl]alanine; 3,5,3′-Triiodo-L-thyronine; 3,3',5'-TRIIODO-DL-THYRONINE; L-3,3',5-triiodo-Thyronine; T 3; (S)-2-Amino-3-(4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl)propanoic acid; EINECS 229-999-3; MFCD00036864; O-(4-hydroxy-3-iodo-phenyl)-3,5-diiodo-L-tyrosine; 3,5,3'-TRIIODO-L-THYRONINE; L-triiodothyronine; L-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-Alanine; 3,3',5'-TRIIODO-L-THYRONINE; 3,3',5-TRIIODO-L-THYRONINE, FREE ACID; 3,3',5-Triiodo-L-thyro
Molecular FormulaC15H12I3NO4
Molecular Weight650.97
Purity≥95 (HPLC)%
Density2.4±0.1 g/cm3
Boiling Point563.5±50.0 °C at 760 mmHg
Melting Point234-238 °C (lit.)
Appearancepowder
EINECS229-999-3
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 6893-02-3 |
| Catalog No. | 2A-9060715 |
| Chinese Name | 三碘甲状腺原氨酸 |
| Synonyms | 3,3',5 TRIIODOTHYRONINE (T3), IRMM STANDARD; 3,5,3′-tri-iodo-l-thyronine; Liothyronine (T3); T3, O-(4-HYDROXY-3-IODOPHENYL)-3,5-DIIODO-L-TYROSINE; O-(4-Hydroxy-3-iodophenyl)-3,5-diiodotyrosine; L T3; O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine; 3,3',5-Triiodothyronine; Triiodothyronine; L-3-[4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodophenyl]alanine; 3,5,3′-Triiodo-L-thyronine; 3,3',5'-TRIIODO-DL-THYRONINE; L-3,3',5-triiodo-Thyronine; T 3; (S)-2-Amino-3-(4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl)propanoic acid; EINECS 229-999-3; MFCD00036864; O-(4-hydroxy-3-iodo-phenyl)-3,5-diiodo-L-tyrosine; 3,5,3'-TRIIODO-L-THYRONINE; L-triiodothyronine; L-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-Alanine; 3,3',5'-TRIIODO-L-THYRONINE; 3,3',5-TRIIODO-L-THYRONINE, FREE ACID; 3,3',5-Triiodo-L-thyro |
| Molecular Formula | C15H12I3NO4 |
| Molecular Weight | 650.97 |
| Purity | ≥95 (HPLC) |
| Density | 2.4±0.1 g/cm3 |
| Boiling Point | 563.5±50.0 °C at 760 mmHg |
| Melting Point | 234-238 °C (lit.) |
| Appearance | powder |
| Storage Condition | Store sealed and away from light. |
| Application | 3,3',5-Triiodo-L-thyronine is a potent agonist of thyroid hormone receptors TRα and TRβ with a Ki value of 2.3 nM. |
| EINECS | 229-999-3 |
| HTC | 2922509090 |
| PubChem ID | 24900088 |
| MDL Number | MFCD00002593 |
| SMILES | N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(O)=O |
| InChI | 1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 |
| InChI Key | AUYYCJSJGJYCDS-LBPRGKRZSA-N |
| Beilstein/REAXYS | 2710227 |
| NACRES Code | NA.32 |
| UNSPSC | 51111800 |
| Hazard Symbols | transportation |
| MSDS | msds/60715_1_6893_02_3.pdf |
| Bioactivity | 3,3',5-Triiodo-L-thyronine is a potent agonist of thyroid hormone receptors TRα and TRβ with Kis of 2.3 nM. Related Catalog Signaling Pathways >> Others >> Thyroid Hormone Receptor Research Areas >> Cancer Research Areas >> Endocrinology Target Human Endogenous Metabolite In Vitro 3,3',5-Triiodo-L-thyronine (T3, 100 nM) stimulates the proliferation of hepatocarcinema cells in which TRβ1 is overexpressed[1]. 3,3',5-Triiodo-L-thyronine binds to human β1 thyroid hormone receptor (hTRβ1), and change its conformation. 3,3',5-Triiodo-L-thyronine promotes growth, induces differentiation and regualtes metabolic effects[2]. Cell Assay Thyroid hormone depleted (Td) serum is prepared. The growth of hepatocarcinoma cells in methylcellulose is performed. To determine the effect of 3,3',5-Triiodo-L-thyronine (T3) on the growth of cells, cells are plated at a density of 3 × l04 cells/60 mm dish on day 0, and incubated in medium containing 5% regular serum, 5% Td or 5% Td and 100 nM T3. The colony formation in methylcellulose is scored 3 weeks after initial plating[1]. References [1]. Lin KH, et al. Stimulation of proliferation by 3,3',5-triiodo-L-thyronine in poorly differentiated human hepatocarcinoma cells overexpressing beta 1 thyroid hormone receptor. Cancer Lett. 1994 Oct 14;85(2):189-94. [2]. Bhat MK, et al. Conformational changes of human beta 1 thyroid hormone receptor induced by binding of 3,3',5-triiodo-L-thyronine. Biochem Biophys Res Commun. 1993 Aug 31;195(1):385-92. Chemical & Physical Properties Density 2.4±0.1 g/cm3 Boiling Point 563.5±50.0 °C at 760 mmHg Melting Point 234-238 °C(lit.) Molecular Formula C15H12I3NO4 Molecular Weight 650.974 Flash Point 294.6±30.1 °C Exact Mass 650.790039 PSA 92.78000 LogP 5.08 Vapour Pressure 0.0±1.6 mmHg at 25°C Index of Refraction 1.763 InChIKey AUYYCJSJGJYCDS-LBPRGKRZSA-N SMILES NC(Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(=O)O |
| Use of | 3,3',5-Triiodo-L-thyronine is a potent agonist of thyroid hormone receptors TRα and TRβ with Kis of 2.3 nM. Properties Articles77 Name 3,3',5-triiodo-L-thyronine Synonym More Synonyms liothyronine Biological Activity Description 3,3',5-Triiodo-L-thyronine is a potent agonist of thyroid hormone receptors TRα and TRβ with Kis of 2.3 nM. Related Catalog Signaling Pathways >> Others >> Thyroid Hormone Receptor Research Areas >> Cancer Research Areas >> Endocrinology Human Endogenous Metabolite In Vitro 3,3',5-Triiodo-L-thyronine (T3, 100 nM) stimulates the proliferation of hepatocarcinema cells in which TRβ1 is overexpressed[1]. 3,3',5-Triiodo-L-thyronine binds to human β1 thyroid hormone receptor (hTRβ1), and change its conformation. 3,3',5-Triiodo-L-thyronine promotes growth, induces differentiation and regualtes metabolic effects[2]. References [1]. Lin KH, et al. Stimulation of proliferation by 3,3',5-triiodo-L-thyronine in poorly differentiated human hepatocarcinoma cells overexpressing beta 1 thyroid hormone receptor. Cancer Lett. 1994 Oct 14;85(2):189-94. [2]. Bhat MK, et al. Conformational changes of human beta 1 thyroid hormone receptor induced by binding of 3,3',5-triiodo-L-thyronine. Biochem Biophys Res Commun. 1993 Aug 31;195(1):385-92. Chemical & Physical Properties Molecular Formula C15H12I3NO4 Exact Mass 650.790039 PSA 92.78000 Index of Refraction 1.763 InChIKey AUYYCJSJGJYCDS-LBPRGKRZSA-N |
| Tax Rebate | 13.0% |
| Supervision | A. Customs clearance form for inbound goods B. Customs clearance form for outbound goods |
| Inspection | R. Hygiene supervision and inspection of imported food S. Hygiene supervision and inspection of exported food |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip. |
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