CAS Number34221-41-5
SynonymsEchinatin; Retrochalcone; (2E)-3-(4-Hydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)-2-propen-1-one; Echinantin; 2-methoxy-4,4'-dihydroxychalcone; (2E)-3-(4-hydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one; loureirin C; (E)-4,4'-Dihydroxy-2-methoxychalcone; 4',4-dihydroxy-2-methoxychalcone
Molecular FormulaC16H14O4
Molecular Weight270.28
Purity≥95.0 (HPLC)%
Density1.3±0.1 g/cm3
Boiling Point509.8±50.0 °C at 760 mmHg
Melting Point210ºC (dec.)
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| Chemical & Physical Properties | |
|---|---|
| CAS Number | 34221-41-5 |
| Catalog No. | 2A-9060676 |
| Chinese Name | 刺甘草查尔酮 |
| Synonyms | Echinatin; Retrochalcone; (2E)-3-(4-Hydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)-2-propen-1-one; Echinantin; 2-methoxy-4,4'-dihydroxychalcone; (2E)-3-(4-hydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one; loureirin C; (E)-4,4'-Dihydroxy-2-methoxychalcone; 4',4-dihydroxy-2-methoxychalcone |
| Molecular Formula | C16H14O4 |
| Molecular Weight | 270.28 |
| Purity | ≥95.0 (HPLC) |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 509.8±50.0 °C at 760 mmHg |
| Melting Point | 210ºC (dec.) |
| Storage Condition | 2-8°C |
| Application | Echinatin is a chalcone isolated from the Chinese herb licorice and has hepatoprotective and anti-inflammatory effects. Echinatin causes antioxidant effects via electron transfer (ET) and proton trans |
| HTC | 2914509090 |
| MDL Number | MFCD00075719 |
| SMILES | O(C)c1c(ccc(c1)O)\C=C\C(=O)c2ccc(cc2)O |
| InChI | 1S/C16H14O4/c1-20-16-10-14(18)8-4-12(16)5-9-15(19)11-2-6-13(17)7-3-11/h2-10,17-18H,1H3/b9-5+ |
| InChI Key | QJKMIJNRNRLQSS-WEVVVXLNSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/60676_1_34221_41_5.pdf |
| Use of | Echinatin is a chalcone isolated from the Chinese herbal medicine Gancao with hepatoprotective and anti-inflammatory effects. Echinatin may undergo an electron transfer (ET) and a proton transfer (PT) to cause the antioxidant action in aqueous solution[1]. Echinatin can be quickly absorbed and eliminated and extensively distributed with an absolute bioavailability of approximately 6.81% in Rat[2]. Properties Name (E)-3-(4-hydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one Synonym More Synonyms Echinatin Biological Activity Description Echinatin is a chalcone isolated from the Chinese herbal medicine Gancao with hepatoprotective and anti-inflammatory effects. Echinatin may undergo an electron transfer (ET) and a proton transfer (PT) to cause the antioxidant action in aqueous solution[1]. Echinatin can be quickly absorbed and eliminated and extensively distributed with an absolute bioavailability of approximately 6.81% in Rat[2]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology References [1]. Liang M, et al. Antioxidant Mechanisms of Echinatin and Licochalcone A. Molecules. 2018 Dec 20;24(1). [2]. Inoue B, et al. The effects of echinatin and its related compounds on the mitochondrial energy transfer reaction. J Toxicol Sci. 1982 Nov;7(4):245-54. Chemical & Physical Properties Molecular Formula C16H14O4 Exact Mass 270.089203 PSA 66.76000 Index of Refraction 1.658 InChIKey QJKMIJNRNRLQSS-WEVVVXLNSA-N Safety Information HS Code 2914509090 Synthetic Route Total: 1 Page 4-hydroxy-o-ani... CAS#:18278-34-7 4-Hydroxyacetop... CAS#:99-93-4 CAS#:34221-41-5 Literature: Achenbach, Hans; Stoecker, Markus; Constenla, Manuel A. Phytochemistry (Elsevier), 1988 , vol. 27, # 6 p. 1835 - 1842 1-[4-(Tetrahydr... CAS#:16162-69-9 2-METHOXY-4-((T... CAS#:163041-68-7 CAS#:34221-41-5 Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 11 p. 3320 - 3324 1-(4-hydroxy-2-... CAS#:493-33-4 4-Hydroxyacetop... CAS#:99-93-4 CAS#:34221-41-5 Literature: Phytochemistry (Elsevier), , vol. 19, p. 2179 - 2184 Precursor & DownStream Precursor 4 CAS#:18278-34-7 4-hydroxy-o-ani... CAS#:99-93-4 4-Hydroxyacetop... CAS#:16162-69-9 1-[4-(Tetrahydr... CAS#:163041-68-7 2-METHOXY-4-((T... DownStream 0 |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 5.5% Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0% |
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