CAS Number60084-10-8
Synonyms(1R)-1,4-Anhydro-1-(4-carbamoyl-1,3-thiazol-2-yl)-D-ribitol; Riboxamide; 2-b-D-Ribofuranosyl-4-thiazolecarboxamide; Tiazofurina [Spanish]; 2-β-D-Ribofuranosyl-4-thiazolecarboxamide; [3H]-Tiazofurin; Tiazofurine; Tiazole; Tiazofurin; Tiazofurina; Tiazofurinum; 2-β-D-Ribofuranosylthiazole-4-carboxamide; Tiazofurinum [Latin]
Molecular FormulaC9H12O5N2S1
Molecular Weight260.27
Density1.6±0.1 g/cm3
Boiling Point641.3±55.0 °C at 760 mmHg
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 60084-10-8 |
| Catalog No. | 2A-9060190 |
| Chinese Name | 噻唑呋林 |
| Synonyms | (1R)-1,4-Anhydro-1-(4-carbamoyl-1,3-thiazol-2-yl)-D-ribitol; Riboxamide; 2-b-D-Ribofuranosyl-4-thiazolecarboxamide; Tiazofurina [Spanish]; 2-β-D-Ribofuranosyl-4-thiazolecarboxamide; [3H]-Tiazofurin; Tiazofurine; Tiazole; Tiazofurin; Tiazofurina; Tiazofurinum; 2-β-D-Ribofuranosylthiazole-4-carboxamide; Tiazofurinum [Latin] |
| Molecular Formula | C9H12O5N2S1 |
| Molecular Weight | 260.27 |
| Density | 1.6±0.1 g/cm3 |
| Boiling Point | 641.3±55.0 °C at 760 mmHg |
| Storage Condition | 2-8°C, protected from light, stored under inert ga |
| Application | Thiazofurane is a synthetic nucleoside analog with antitumor activity. Thiazofurane is metabolized intracellularly to thiazole-4-carboxamide adenine dinucleotide (TAD), a potent inhibitor of IMP dehyd |
| HTC | 2934100090 |
| MDL Number | MFCD00866494 |
| SMILES | NC(=O)c1csc(n1)C2OC(CO)C(O)C2O |
| InChI | InChI=1S/C9H12N2O5S/c10-8(15)3-2-17-9(11-3)7-6(14)5(13)4(1-12)16-7/h2,4-7,12-14H,1H2,(H2,10,15) |
| InChI Key | InChIKey=FVRDYQYEVDDKCR-UHFFFAOYSA-N |
| MSDS | msds/60190_1_60084_10_8.pdf |
| Use of | Tiazofurin is a synthetic nucleoside analogue with antineoplastic activity. Tiazofurin is anabolized intracellularly to tiazole-4-carboxamide adenine dinucleotide (TAD), a potent inhibitor of IMP dehydrogenase (IMPDH). Properties Name 2-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3-thiazole-4-carboxamide Synonym More Synonyms Tiazofurin Biological Activity Description Tiazofurin is a synthetic nucleoside analogue with antineoplastic activity. Tiazofurin is anabolized intracellularly to tiazole-4-carboxamide adenine dinucleotide (TAD), a potent inhibitor of IMP dehydrogenase (IMPDH). Related Catalog Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog References [1]. Tricot G, Jayaram HN, Weber G, Hoffman R. Tiazofurin: biological effects and clinical uses. Int J Cell Cloning. 1990;8(3):161-170. Chemical & Physical Properties Molecular Formula C9H12N2O5S Exact Mass 260.046692 PSA 154.14000 LogP -1.13 Index of Refraction 1.675 Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : 4-Thiazolecarboxamide, 2-beta-D-ribofuranosyl- CAS REGISTRY NUMBER : 60084-10-8 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C9-H12-N2-O5-S MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : DOSE/DURATION : TOXIC EFFECTS : Behavioral - headache Musculoskeletal - other changes TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : DOSE/DURATION : TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Blood - other changes TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Behavioral - fluid intake TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SEX/DURATION : male 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - testes, epididymis, sperm duct MUTATION DATA TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Rodent - mouse Lymphocyte DOSE/DURATION : REFERENCE : Safety Information Hazard Codes Xi HS Code 2934100090 Synthetic Route b-D-Ribofuranos... Tiazofurin 60084-10-8 Literature: Nucleosides, Nucleotides and Nucleic Acids, , vol. 23, # 4 p. 715 - 724 methyl 3,5-O-di... 52783-53-6 Tiazofurin 60084-10-8 Literature: Nucleosides, Nucleotides and Nucleic Acids, , vol. 23, # 4 p. 715 - 724 methyl 3'-O... Tiazofurin 60084-10-8 Literature: Nucleosides, Nucleotides and Nucleic Acids, , vol. 23, # 4 p. 715 - 724 Precursor & DownStream Precursor 5 CAS#:60084-09-5 2-((Benzoyloxy)... CAS#:95936-53-1 2-β-D-Ribofuran... CAS#:57944-10-2 (3,4-dibenzoylo... CAS#:23316-67-8 2,3,5-Tri-O-ben... DownStream 3 CAS#:83285-83-0 [[5-(6-aminopur... CAS#:92952-33-5 4-Thiazolecarbo... CAS#:92952-40-4 4-Thiazolecarbo... |
| Tax Rebate | 9.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0% |
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