| Chemical & Physical Properties | |
|---|---|
| CAS Number | 357336-74-4 |
| Catalog No. | 2A-9060096 |
| Chinese Name | Seletracetam |
| Synonyms | Seletracetam; Seletracetam (USAN/INN) |
| Molecular Formula | C10H14F2N2O2 |
| Molecular Weight | 232.22700 |
| Application | Seletracetam (Ucb 44212) is an analogue of the antiepileptic drug Levetiracetam. Seletracetam is a small molecule SV2A modulator used in epilepsy research. |
| HTC | 2933790090 |
| SMILES | CCC(C(N)=O)N1CC(C=C(F)F)CC1=O |
| InChI Key | ANWPENAPCIFDSZ-RQJHMYQMSA-N |
| Use of | Seletracetam (Ucb 44212) is an analog of the antiepileptic agent Levetiracetam. Seletracetam is a small molecule SV2A modulator for the research of epilepsy[1][2][3]. Properties Name (2S)-2-[(4S)-4-(2,2-difluoroethenyl)-2-oxopyrrolidin-1-yl]butanamide Synonym More Synonyms Seletracetam Biological Activity Description Seletracetam (Ucb 44212) is an analog of the antiepileptic agent Levetiracetam. Seletracetam is a small molecule SV2A modulator for the research of epilepsy[1][2][3]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease In Vitro Seletracetam decreases seizure activity in a number of epilepsy models and binds to the synaptic vesicle protein SV2A[2]. Seletracetam decreases synaptic responses in a time-, frequency- and concentration-dependent manner[2]. Seletracetam modifies rates of presynaptic release[2]. Seletracetam inhibits high-voltage-activated Ca2+ currents and intracellular Ca2+ increase in rat cortical neurons in vitro[2]. References [1]. Pollard JR, et al. Seletracetam, a small molecule SV2A modulator for the treatment of epilepsy. Curr Opin Investig Drugs. 2008 Jan;9(1):101-7. [2]. Yang X, et al. Seletracetam enhances short term depression in vitro. Epilepsy Res. 2015 Nov;117:17-22. [3]. Martella G, et al. Seletracetam (ucb 44212) inhibits high-voltage-activated Ca2+ currents and intracellular Ca2+ increase in rat cortical neurons in vitro. Epilepsia. 2009 Apr;50(4):702-10. Chemical & Physical Properties Molecular Formula C10H14F2N2O2 Exact Mass 232.10200 PSA 64.39000 LogP 1.96680 InChIKey ANWPENAPCIFDSZ-RQJHMYQMSA-N Safety Information HS Code 2933790090 |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 9.0% Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0% |
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