![(S)-3-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-1-METHYL-2-OXO-IMIDAZOLIDINE-4-CARBOXYLIC ACID structure, CAS 89396-94-1](/structures/80000/60029_1_89396_94_1.png)
CAS Number89396-94-1
SynonymsImidapril HCl; (1S)-1-(Ethoxycarbonyl)-3-phenylpropyl>-1-methyl-2-oxoimidazolidine-4-carboxylic Acid Hydrochloride; Imidapril Hydrochloride [JAN]; Imidapril monohydrochloride; TA-6366; Imidapril hydrochloride; Imidapril (hydrochloride)
Molecular FormulaC20H28ClN3O6
Molecular Weight441.91
Boiling Point577ºC at 760 mmHg
Melting Point38-42ºC
AppearanceWhite off-white crystal-powder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 89396-94-1 |
| Catalog No. | 2A-9060029 |
| Chinese Name | 盐酸咪达普利 |
| Synonyms | Imidapril HCl; (1S)-1-(Ethoxycarbonyl)-3-phenylpropyl>-1-methyl-2-oxoimidazolidine-4-carboxylic Acid Hydrochloride; Imidapril Hydrochloride [JAN]; Imidapril monohydrochloride; TA-6366; Imidapril hydrochloride; Imidapril (hydrochloride) |
| Molecular Formula | C20H28ClN3O6 |
| Molecular Weight | 441.91 |
| Boiling Point | 577ºC at 760 mmHg |
| Melting Point | 38-42ºC |
| Appearance | White off-white crystal-powder |
| Storage Condition | Room temperature, dry, inert gas storage |
| Application | Imidapril hydrochloride is an angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. |
| MDL Number | C20H27N3O6·HCl |
| SMILES | CCOC(=O)C(CCc1ccccc1)NC(C)C(=O)N1C(=O)N(C)CC1C(=O)O.Cl |
| InChI | InChI=1S/C20H27N3O6.ClH/c1-4-29-19(27)15(11-10-14-8-6-5-7-9-14)21-13(2)17(24)23-16(18(25)26)12-22(3)20(23)28;/h5-9,13,15-16,21H,4,10-12H2,1-3H3,(H,25,26);1H/t13-,15-,16-;/m0./s1 |
| InChI Key | LSLQGMMMRMDXHN-GEUPQXMHSA-N |
| Hazard Symbols | transportation |
| MSDS | msds/60029_1_89396_94_1.pdf |
| Bioactivity | Imidapril Hydrochloride is the hydrochloride salt of Imidapril, an angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Target: ACEAs a prodrug, Imidapril is converted by hydrolysis in the liver into its active form imidaprilat. Imidaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Imidaprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE) Research Areas >> Cardiovascular Disease Chemical & Physical Properties Boiling Point 577ºC at 760 mmHg Melting Point 38-42ºC Molecular Formula C20H28ClN3O6 Molecular Weight 441.91 PSA 116.25000 LogP 1.14290 InChIKey LSLQGMMMRMDXHN-GEUPQXMHSA-N SMILES CCOC(=O)C(CCc1ccccc1)NC(C)C(=O)N1C(=O)N(C)CC1C(=O)O.Cl |
| Use of | Imidapril Hydrochloride is the hydrochloride salt of Imidapril, an angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Target: ACEAs a prodrug, Imidapril is converted by hydrolysis in the liver into its active form imidaprilat. Imidaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Imidaprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow. Properties Articles30 Name (4S)-3-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-1-methyl-2-oxoimidazolidine-4-carboxylic acid,hydrochloride Synonym More Synonyms Imidapril (hydrochloride) Biological Activity Description Imidapril Hydrochloride is the hydrochloride salt of Imidapril, an angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Target: ACEAs a prodrug, Imidapril is converted by hydrolysis in the liver into its active form imidaprilat. Imidaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Imidaprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE) Research Areas >> Cardiovascular Disease Chemical & Physical Properties PSA 116.25000 LogP 1.14290 InChIKey LSLQGMMMRMDXHN-GEUPQXMHSA-N |
| Transport Info | Product name: Purity: 99.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
| Related Products in Pharmaceutical Intermediates | ||
|---|---|---|
| (2R,5R)-L-Menthyl-5-(acetyloxy)-1,3-oxathiolane-2-carboxylate | 147027-09-6 | 2A-9059881 |
| N-BOC-INDOLINE-7-CARBOXYLIC ACID | 143262-20-8 | 2A-9059904 |
| 3-(tert-butoxycarbonylamino)-2-methoxyisonicotinate | 870997-82-3 | 2A-9059917 |
| 3-[[[(2S,4S)-4-Mercapto-1-(4-nitrobenzyloxy)carbonyl-2-pyrrolidinyl]carbonyl]amino]benzoic acid | 202467-69-4 | 2A-9059987 |
| (S)-(+)-CITRAMALIC ACID | 6236-09-5 | 2A-9060006 |
| (S)-3-HYDROXYGLUTARATE ETHYL | 95310-88-6 | 2A-9060039 |
| (R)-2,2-DIMETHYL-1,3-DIOXOLANE-4-ACETIC ACID, METHYL ESTER | 112031-10-4 | 2A-9060040 |
| (S)-methyl 3,4-dihydroxybutanoate | 90414-36-1 | 2A-9060042 |
| (S)-tert-Butanesulfinamide | 146374-27-8 | 2A-9060174 |
| (R)-1-(4-CHLOROPHENYL)-1-PROPANOL | 110611-21-7 | 2A-9060184 |
| Browse all Pharmaceutical Intermediates products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS