CAS Number84225-95-6
Synonymsdes-His1-[Glu9]-Glucagon (1-29) amide; FLA 870; PRASEODYMIUM(III) TRIFLUOROMETHANESULFONATE; 3,5-DICHLORO-N-[[(2S)-1-ETHYL-2-PYRROLIDINYL]METHYL]-2-HYDROXY-6-METHOXYBENZAMIDE; (S)-3,5-Dichloro-N-((1-ethylpyrrolidin-2-yl)methyl)-2-hydroxy-6-methoxybenzamide; 3,5-DICHLORO-N-(((2S)-1-ETHYL-2-PYRROLIDINYL)METHYL)-2-HYDROXY-6-METHOXYBENZAMIDE; S(-)-Raclopride L-Tartrate; RACLOPRIDE; raclopride; (S)-(-)-RACLOPRIDE
Molecular FormulaC15H20Cl2N2O3
Molecular Weight347.24
Density1.288g/cm3
Boiling Point420.3ºC at 760 mmHg
Melting Point54 °C
AppearanceSolid;White to Light red to Green powder to crystal
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 84225-95-6 |
| Catalog No. | 2A-9059968 |
| Chinese Name | 雷氯必利 |
| Synonyms | des-His1-[Glu9]-Glucagon (1-29) amide; FLA 870; PRASEODYMIUM(III) TRIFLUOROMETHANESULFONATE; 3,5-DICHLORO-N-[[(2S)-1-ETHYL-2-PYRROLIDINYL]METHYL]-2-HYDROXY-6-METHOXYBENZAMIDE; (S)-3,5-Dichloro-N-((1-ethylpyrrolidin-2-yl)methyl)-2-hydroxy-6-methoxybenzamide; 3,5-DICHLORO-N-(((2S)-1-ETHYL-2-PYRROLIDINYL)METHYL)-2-HYDROXY-6-METHOXYBENZAMIDE; S(-)-Raclopride L-Tartrate; RACLOPRIDE; raclopride; (S)-(-)-RACLOPRIDE |
| Molecular Formula | C15H20Cl2N2O3 |
| Molecular Weight | 347.24 |
| Density | 1.288g/cm3 |
| Boiling Point | 420.3ºC at 760 mmHg |
| Melting Point | 54 °C |
| Appearance | Solid;White to Light red to Green powder to crystal |
| Water Solubility | Soluble in: methanol |
| Storage Condition | Store under inert gas; avoid air |
| Application | Raclopride is a dopamine D2/D3 receptor antagonist that binds to D2 and D3 receptors with Ki of 1.8 nM and 3.5 nM, respectively, but has very low affinity for D1 and D4 receptors, with Ki of 18000 nM |
| MDL Number | C15H20Cl2N2O3 |
| SMILES | CCN1CCCC1CNC(=O)c1c(O)c(Cl)cc(Cl)c1OC |
| InChI | InChI=1S/C15H20Cl2N2O3/c1-3-19-6-4-5-9(19)8-18-15(21)12-13(20)10(16)7-11(17)14(12)22-2/h7,9,20H,3-6,8H2,1-2H3,(H,18,21)/t9-/m1/s1 |
| InChI Key | WAOQONBSWFLFPE-VIFPVBQESA-N |
| MSDS | msds/59968_1_84225_95_6.pdf |
| Bioactivity | Raclopride is a dopamine D2/D3 receptor antagonist, which binds to D2 and D3 receptors with dissociation constants (Kis) of 1.8 nM and 3.5 nM, respectively, but has a very low affinity for D1 and D4 receptors with Kis of 18000 nM and 2400 nM, respectively[1]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease Target Ki: 1.8 nM (D2 receptor), 3.5 nM (D3 receptor), 2400 nM (D4 receptor), 18000 nM (D1 receptor)[1] References [1]. Seeman P, et al. Dopamine receptor pharmacology. Trends Pharmacol Sci. 1994 Jul;15(7):264-70. Chemical & Physical Properties Density 1.288g/cm3 Boiling Point 420.3ºC at 760 mmHg Melting Point 54 °C Molecular Formula C15H20Cl2N2O3 Molecular Weight 347.24 Flash Point 208ºC Exact Mass 346.08500 PSA 61.80000 LogP 3.25050 Index of Refraction 1.563 InChIKey WAOQONBSWFLFPE-VIFPVBQESA-N SMILES CCN1CCCC1CNC(=O)c1c(O)c(Cl)cc(Cl)c1OC |
| Use of | Properties Name 3,5-dichloro-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2-hydroxy-6-methoxybenzamide Synonym More Synonyms Raclopride Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease Ki: 1.8 nM (D2 receptor), 3.5 nM (D3 receptor), 2400 nM (D4 receptor), 18000 nM (D1 receptor)[1] References [1]. Seeman P, et al. Dopamine receptor pharmacology. Trends Pharmacol Sci. 1994 Jul;15(7):264-70. Chemical & Physical Properties Exact Mass 346.08500 PSA 61.80000 LogP 3.25050 Index of Refraction 1.563 InChIKey WAOQONBSWFLFPE-VIFPVBQESA-N |
| Transport Info | Product name: Purity: 95.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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