CAS Number145158-71-0
Synonyms(2E)-2-[(5-Methoxy-1H-indol-3-yl)methylene]-N-pentylhydrazinecarboximidamide; tegaserodum; (2E)-2-[(5-methoxy-1H-indol-3-yl)methylidene]-N-pentylhydrazinecarboximidamide; Zelmac; MFCD06660144; Tegaserode; (2E)-2-[(5-methoxy-1H-indol-3-yl)methylidene]-N'-pentylhydrazinecarboximidamide; Tegaserod
Molecular FormulaC16H23N5O
Molecular Weight301.39
Density1.2±0.1 g/cm3
Boiling Point470.6±48.0 °C at 760 mmHg
Melting Point180-183ºC
Appearancewhite powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 145158-71-0 |
| Catalog No. | 2A-9059613 |
| Chinese Name | 马来酸替加色罗 |
| Synonyms | (2E)-2-[(5-Methoxy-1H-indol-3-yl)methylene]-N-pentylhydrazinecarboximidamide; tegaserodum; (2E)-2-[(5-methoxy-1H-indol-3-yl)methylidene]-N-pentylhydrazinecarboximidamide; Zelmac; MFCD06660144; Tegaserode; (2E)-2-[(5-methoxy-1H-indol-3-yl)methylidene]-N'-pentylhydrazinecarboximidamide; Tegaserod |
| Molecular Formula | C16H23N5O |
| Molecular Weight | 301.39 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 470.6±48.0 °C at 760 mmHg |
| Melting Point | 180-183ºC |
| Appearance | white powder |
| Application | Tegaserod is a serotonin receptor 4 agonist (HTR4) used to treat irritable bowel syndrome (IBS). Antitumor activity[1]. |
| HTC | 2933990090 |
| MDL Number | C16H23N5O |
| SMILES | CCCCCN=C(N)NN/C=C/1C=Nc2ccc(CO)cc12.OC(=O)\C=C\C(O)=O |
| InChI | InChI=1S/C16H23N5O.C4H4O4/c1-2-3-4-7-18-16(17)21-20-10-13-9-19-15-6-5-12(11-22)8-14(13)15;5-3(6)1-2-4(7)8/h5-6,8-10,20,22H,2-4,7,11H2,1H3,(H3,17,18,21);1-2H,(H,5,6)(H,7,8)/b13-10+;2-1+ |
| InChI Key | InChIKey=PINGCSUEYQYSEB-GFQXDJOGSA-N |
| MSDS | msds/59613_1_145158_71_0.pdf |
| Use of | Tegaserod is a serotonin receptor 4 agonist (HTR4) used in the treatment of irritable bowel syndrome (IBS). Anti-tumor activity[1]. Properties Name tegaserod Synonym More Synonyms Tegaserod Biological Activity Description Tegaserod is a serotonin receptor 4 agonist (HTR4) used in the treatment of irritable bowel syndrome (IBS). Anti-tumor activity[1]. Related Catalog Research Areas >> Cancer Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor 5-HT4 Receptor References [1]. Wei Liu, et al. Repurposing the serotonin agonist Tegaserod as an anticancer agent in melanoma: molecular mechanisms and clinical implications. J Exp Clin Cancer Res. 2020 Feb 21;39(1):38. Chemical & Physical Properties Molecular Formula C16H23N5O Exact Mass 301.190247 PSA 159.89000 Index of Refraction 1.597 Safety Information Hazard Codes Xi HS Code 2933990090 Synthetic Route Total: 1 Page 3-(5-methoxy-1H... CAS#:843609-64-3 CAS#:145158-71-0 5-Methoxy-1H-in... CAS#:10601-19-1 N-amino-N'-pent... CAS#:1043452-36-3 CAS#:145158-71-0 Literature: EP1955998 A1, ; Page/Page column 3 ; Precursor & DownStream Precursor 3 CAS#:843609-64-3 3-(5-methoxy-1H... CAS#:10601-19-1 5-Methoxy-1H-in... CAS#:1043452-36-3 N-amino-N'-pent... DownStream 1 CAS#:189188-57-6 Tegaserod maleate |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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