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Home > Products > Pharmaceuticals & Life Science > Pharmaceutical Intermediates > 6-[Difluoro[6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]methyl]quinoline
6-[Difluoro[6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]methyl]quinoline structure, CAS 943540-75-8

6-[Difluoro[6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]methyl]quinoline

CAS Number943540-75-8

Synonyms6-{Difluoro[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}quinoline; JNJ-38877605

Molecular FormulaC19H13N7F2

Molecular Weight377.36

Purity98.00%

Density1.5±0.1 g/cm3

Boiling Point

Melting Point

Flash Point

Appearancepowder

EINECS

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Cat. No.: 2A-9059299 Purity: 98.00%
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Quality Control of [ 943540-75-8 ] Purity: 98.00% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number943540-75-8
Catalog No.2A-9059299
Chinese Name6-[二氟[6-(1-甲基-1H-吡唑-4-基)-1,2,4-三唑并[4,3-b]哒嗪-3-基]甲基]喹啉
Synonyms6-{Difluoro[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}quinoline; JNJ-38877605
Molecular FormulaC19H13N7F2
Molecular Weight377.36
Purity98.00
Density1.5±0.1 g/cm3
Appearancepowder
Storage Condition-20℃
ApplicationJNJ-38877605 is an ATP-competitive c-Met inhibitor with an IC50 of 4 nM. Its inhibitory effect on c-Met is 600 times stronger than that of other 200 tyrosine and serine-threonine kinases.
HTC2933990090
MDL NumberMFCD11977274
SMILESCn1cc(-c2ccc3nnc(C(F)(F)c4ccc5ncccc5c4)n3n2)cn1
InChI KeyJRWCBEOAFGHNNU-UHFFFAOYSA-N
MSDSmsds/59299_1_943540_75_8.pdf
Use ofProperties Name 6-[difluoro-[6-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl]quinoline Synonym More Synonyms JNJ-38877605 Biological Activity Related Catalog Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Met/HGFR Research Areas >> Cancer References [1]. Perera T, et al. Presented at the 99th AACR Annual Meeting; 2008 Apr 12-16; San Diego (CA): Abst [2]. De Bacco F, et al. Induction of MET by ionizing radiation and its role in radioresistance and invasive growth of cancer. J Natl Cancer Inst. 2011 Apr, 103(8), 645-661. [3]. Torti D, et al. A preclinical algorithm of soluble surrogate biomarkers that correlate with therapeutic inhibition of the MET oncogene in gastric tumors. Int J Cancer. 2012, 130(6), 1357-1366. Chemical & Physical Properties Molecular Formula C19H13F2N7 Exact Mass 377.120056 PSA 73.79000 Index of Refraction 1.734 InChIKey JRWCBEOAFGHNNU-UHFFFAOYSA-N Storage condition -20℃ Safety Information Hazard Codes N HS Code 2933990090
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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