![4-[3-[4-Cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]-2-fluoro-N-methylbenzamide structure, CAS 915087-33-1](/structures/60000/59107_1_915087_33_1.png)
CAS Number915087-33-1
SynonymsMDV3100; MDV 3100; Enzalutamide; Enzalutamidum; 4-(3-(4-Cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-N-me; Xtandi; UNII-93T0T9GKNU; Enzalutamida; MDV-3100
Molecular FormulaC21H16O2N4S1F4
Molecular Weight464.44
Purity98.00%
Density1.5±0.1 g/cm3
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 915087-33-1 |
| Catalog No. | 2A-9059107 |
| Chinese Name | 恩杂鲁胺 |
| Synonyms | MDV3100; MDV 3100; Enzalutamide; Enzalutamidum; 4-(3-(4-Cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-N-me; Xtandi; UNII-93T0T9GKNU; Enzalutamida; MDV-3100 |
| Molecular Formula | C21H16O2N4S1F4 |
| Molecular Weight | 464.44 |
| Purity | 98.00 |
| Density | 1.5±0.1 g/cm3 |
| Storage Condition | room temperature, dry |
| Application | Enzalutamide (MDV3100) is an androgen receptor (AR) antagonist with an IC50 value of 36 nM for AR inhibition in LNCaP prostate cells. |
| HTC | 2933990090 |
| MDL Number | MFCD14155804 |
| SMILES | CNC(=O)c1ccc(N2C(=S)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)C2(C)C)cc1F |
| InChI Key | WXCXUHSOUPDCQV-UHFFFAOYSA-N |
| MSDS | msds/59107_1_915087_33_1.pdf |
| Use of | Enzalutamide (MDV3100) is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells. Properties Name enzalutamide Synonym More Synonyms Enzalutamide (MDV3100) Biological Activity Description Enzalutamide (MDV3100) is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells. Related Catalog Signaling Pathways >> Others >> Androgen Receptor Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Cancer IC50: 36 nM (androgen-receptor, in LNCaP cells)[1] References [1]. Tran C, et al. Development of a second-generation antiandrogen for treatment of advanced prostate cancer. Science, 2009, 324 (5928), 787-790. [2]. Scher HI, et al. Antitumour activity of MDV3100 in castration-resistant prostate cancer: a phase 1-2 study. Lancet, 2010, 375(9724), 1437-1446. [3]. Guerrero J, et al. Enzalutamide, an androgen receptor signaling inhibitor, induces tumor regression in a mouse model of castration-resistant prostate cancer. Prostate. 2013 Sep;73(12):1291-305. [4]. Kim TH, et al. Pharmacokinetics of enzalutamide, an anti-prostate cancer drug, in rats. Arch Pharm Res. 2015 Nov;38(11):2076-82. Chemical & Physical Properties Molecular Formula C21H16F4N4O2S Exact Mass 464.093018 PSA 108.53000 Index of Refraction 1.630 InChIKey WXCXUHSOUPDCQV-UHFFFAOYSA-N Safety Information Hazard Codes Xi HS Code 2933990090 Synthetic Route 4-[(2-Cyanoprop... CAS#:915087-32-0 3-Fluoro-4-meth... CAS#:143782-23-4 Enzalutamide (M... CAS#:915087-33-1 N-[3-Fluoro-4-[... CAS#:1332524-01-2 3-Fluoro-4-meth... CAS#:143782-23-4 Enzalutamide (M... CAS#:915087-33-1 Thiophosgene CAS#:463-71-8 4-[1-(4-cyano-3... CAS#:1289942-55-7 Enzalutamide (M... CAS#:915087-33-1 Precursor & DownStream Precursor 9 CAS#:915087-32-0 4-[(2-Cyanoprop... CAS#:143782-23-4 3-Fluoro-4-meth... CAS#:1332524-01-2 N-[3-Fluoro-4-[... CAS#:463-71-8 Thiophosgene DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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